| UniProt ID | S22AN_HUMAN | |
|---|---|---|
| UniProt AC | A1A5C7 | |
| Protein Name | Solute carrier family 22 member 23 | |
| Gene Name | SLC22A23 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 686 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein . |
|
| Protein Description | ||
| Protein Sequence | MAIDRRREAAGGGPGRQPAPAEENGSLPPGDAAASAPLGGRAGPGGGAEIQPLPPLHPGGGPHPSCCSAAAAPSLLLLDYDGSVLPFLGGLGGGYQKTLVLLTWIPALFIGFSQFSDSFLLDQPNFWCRGAGKGTELAGVTTTGRGGDMGNWTSLPTTPFATAPWEAAGNRSNSSGADGGDTPPLPSPPDKGDNASNCDCRAWDYGIRAGLVQNVVSKWDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEGDIKGVIPELEKELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQNLPENISNGEHYTRQPLLPHKKGEQPLLLTNAELKDYSGLHDAAAAGDTLPEGATANGMKAM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 24 | N-linked_Glycosylation | QPAPAEENGSLPPGD CCCCCCCCCCCCCCC | 36.54 | UniProtKB CARBOHYD | |
| 133 | Ubiquitination | FWCRGAGKGTELAGV EEECCCCCCCEEECE | 63.22 | - | |
| 141 | O-linked_Glycosylation | GTELAGVTTTGRGGD CCEEECEECCCCCCC | 20.09 | OGP | |
| 142 | O-linked_Glycosylation | TELAGVTTTGRGGDM CEEECEECCCCCCCC | 25.50 | OGP | |
| 143 | O-linked_Glycosylation | ELAGVTTTGRGGDMG EEECEECCCCCCCCC | 18.60 | 55831025 | |
| 162 | O-linked_Glycosylation | LPTTPFATAPWEAAG CCCCCCCCCCHHHCC | 33.36 | OGP | |
| 279 | N-linked_Glycosylation | LTVALSVNVTMFSTL HHHHHHCCHHHHHHH | 21.84 | UniProtKB CARBOHYD | |
| 284 | Phosphorylation | SVNVTMFSTLRFFEG HCCHHHHHHHHHHHH | 18.73 | 24043423 | |
| 285 | Phosphorylation | VNVTMFSTLRFFEGF CCHHHHHHHHHHHHH | 15.64 | 24043423 | |
| 300 | Phosphorylation | CLAGIILTLYALRIE HHHHHHHHHHHHHHH | 13.81 | 24043423 | |
| 302 | Phosphorylation | AGIILTLYALRIELC HHHHHHHHHHHHHHC | 9.80 | 24043423 | |
| 314 (in isoform 3) | Ubiquitination | - | 32.08 | 21906983 | |
| 387 | Phosphorylation | KRLILHFTQKNRMNP HHHHHHHHHHCCCCC | 28.08 | 30622161 | |
| 403 (in isoform 2) | Ubiquitination | - | 37.40 | 21906983 | |
| 410 | Phosphorylation | PELEKELSRRPKKVC HHHHHHHHCCCCCEE | 27.60 | - | |
| 472 | Phosphorylation | FYADYYTTASIALVS HHCHHHHHHHHHHHH | 11.42 | - | |
| 520 | Phosphorylation | LLNLIGKYSQHPDSG HHHHHHHHCCCCCCC | 14.35 | - | |
| 521 | Phosphorylation | LNLIGKYSQHPDSGM HHHHHHHCCCCCCCC | 26.04 | - | |
| 531 | Phosphorylation | PDSGMSDSVKDKFSI CCCCCCHHHHHHHHH | 24.61 | - | |
| 537 | Phosphorylation | DSVKDKFSIAFSIVG HHHHHHHHHHHHHHH | 20.81 | 24043423 | |
| 541 | Phosphorylation | DKFSIAFSIVGMFAS HHHHHHHHHHHHHHH | 13.82 | 22210691 | |
| 548 | Phosphorylation | SIVGMFASHAVGSLS HHHHHHHHHHHHCCE | 10.74 | 24043423 | |
| 553 | Phosphorylation | FASHAVGSLSVFFCA HHHHHHHCCEEEECC | 15.75 | 22210691 | |
| 555 | Phosphorylation | SHAVGSLSVFFCAEI HHHHHCCEEEECCCC | 20.69 | 24043423 | |
| 563 | Phosphorylation | VFFCAEITPTVIRCG EEECCCCCCCEEECC | 12.38 | 24043423 | |
| 565 | Phosphorylation | FCAEITPTVIRCGGL ECCCCCCCEEECCHH | 21.66 | 24043423 | |
| 673 | Phosphorylation | DAAAAGDTLPEGATA CHHHCCCCCCCCCCC | 43.21 | - | |
| 684 (in isoform 1) | Ubiquitination | - | 42.57 | 21906983 | |
| 684 | Ubiquitination | GATANGMKAM----- CCCCCCCCCC----- | 42.57 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of S22AN_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of S22AN_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of S22AN_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| KR108_HUMAN | KRTAP10-8 | physical | 25416956 | |
| NT2NL_HUMAN | NOTCH2NL | physical | 25416956 | |
| BMP4_HUMAN | BMP4 | physical | 28514442 | |
| SIR2_HUMAN | SIRT2 | physical | 28514442 | |
| PAXB1_HUMAN | PAXBP1 | physical | 28514442 | |
| KPRP_HUMAN | KPRP | physical | 28514442 | |
| TAXB1_HUMAN | TAX1BP1 | physical | 28514442 | |
| DCC1_HUMAN | DSCC1 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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