BMP4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BMP4_HUMAN
• UniProt AC: P12644
• Protein Name: Bone morphogenetic protein 4
• Gene Name: BMP4
• Organism: Homo sapiens (Human).
• Sequence Length: 408
• Subcellular Localization: Secreted, extracellular space, extracellular matrix.
• Protein Description: Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity)..
• Protein Sequence: MIPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEATLLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSFHHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWERGFHRINIYEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSPKHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	Phosphorylation	GGRRSGQSHELLRDF CCCCCCCCHHHHHHH	23.58	26091039
76	Phosphorylation	RRPQPSKSAVIPDYM CCCCCCCCCCCCHHH	31.91	26074081
82	Phosphorylation	KSAVIPDYMRDLYRL CCCCCCHHHHHHHHC	6.68	26074081
87	Phosphorylation	PDYMRDLYRLQSGEE CHHHHHHHHCCCCCC	17.36	26074081
91	Phosphorylation	RDLYRLQSGEEEEEQ HHHHHCCCCCCHHHH	53.41	12404109
106	Phosphorylation	IHSTGLEYPERPASR HHHCCCCCCCCCCCC	18.55	26091039
116	Phosphorylation	RPASRANTVRSFHHE CCCCCCCCHHHHCCH	19.13	-
119	Phosphorylation	SRANTVRSFHHEEHL CCCCCHHHHCCHHHH	25.29	-
143	N-linked_Glycosylation	SAFRFLFNLSSIPEN HHHHHHHCCCCCCCC	40.95	UniProtKB CARBOHYD
185	Ubiquitination	INIYEVMKPPAEVVP EEEEEECCCCHHHCC	53.69	2190698
202	Phosphorylation	LITRLLDTRLVHHNV HHHHHHHHCHHCCCC	26.35	22210691
208	N-linked_Glycosylation	DTRLVHHNVTRWETF HHCHHCCCCCCEEEC	23.21	UniProtKB CARBOHYD
228	Ubiquitination	VLRWTREKQPNYGLA HHHHHHCCCCCCEEE	68.70	-
350	N-linked_Glycosylation	FPLADHLNSTNHAIV CCCHHHHCCCCHHHH	43.28	UniProtKB CARBOHYD
365	N-linked_Glycosylation	QTLVNSVNSSIPKAC HHHHHHHCCCCCCHH	29.84	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
91	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BMP4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BMP4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BMR1A_HUMAN	BMPR1A	physical	8006002
BMR1B_HUMAN	BMPR1B	physical	8006002
DCA16_HUMAN	DCAF16	physical	28514442
TWSG1_HUMAN	TWSG1	physical	28514442
UBE2O_HUMAN	UBE2O	physical	28514442
PDP1_HUMAN	PDP1	physical	28514442
SUFU_HUMAN	SUFU	physical	28514442
PROS_HUMAN	PROS1	physical	28514442
CALR_HUMAN	CALR	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 607932: Microphthalmia, syndromic, 6 (MCOPS6)
• 600625: Non-syndromic orofacial cleft 11 (OFC11)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.