TWSG1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TWSG1_HUMAN
• UniProt AC: Q9GZX9
• Protein Name: Twisted gastrulation protein homolog 1
• Gene Name: TWSG1
• Organism: Homo sapiens (Human).
• Sequence Length: 223
• Subcellular Localization: Secreted.
• Protein Description: May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity)..
• Protein Sequence: MKLHYVAVLTLAILMFLTWLPESLSCNKALCASDVSKCLIQELCQCRPGEGNCSCCKECMLCLGALWDECCDCVGMCNPRNYSDTPPTSKSTVEELHEPIPSLFRALTEGDTQLNWNIVSFPVAEELSHHENLVSFLETVNQPHHQNVSVPSNNVHAPYSSDKEHMCTVVYFDDCMSIHQCKISCESMGASKYRWFHNACCECIGPECIDYGSKTVKCMNCMF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MKLHYVAVLTLA ---CCHHHHHHHHHH	10.67	24043423
10	Phosphorylation	LHYVAVLTLAILMFL HHHHHHHHHHHHHHH	13.93	24043423
18	Phosphorylation	LAILMFLTWLPESLS HHHHHHHHHCCHHCC	17.43	24043423
23	Phosphorylation	FLTWLPESLSCNKAL HHHHCCHHCCCCHHH	24.52	24043423
25	Phosphorylation	TWLPESLSCNKALCA HHCCHHCCCCHHHHH	25.56	24043423
52	N-linked_Glycosylation	QCRPGEGNCSCCKEC HCCCCCCCCHHHHHH	15.38	UniProtKB CARBOHYD
81	N-linked_Glycosylation	VGMCNPRNYSDTPPT CCCCCCCCCCCCCCC	41.75	UniProtKB CARBOHYD
82	Phosphorylation	GMCNPRNYSDTPPTS CCCCCCCCCCCCCCC	14.81	23663014
83	Phosphorylation	MCNPRNYSDTPPTSK CCCCCCCCCCCCCCH	38.26	23663014
83	O-linked_Glycosylation	MCNPRNYSDTPPTSK CCCCCCCCCCCCCCH	38.26	OGP
85	Phosphorylation	NPRNYSDTPPTSKST CCCCCCCCCCCCHHH	25.81	23663014
88	Phosphorylation	NYSDTPPTSKSTVEE CCCCCCCCCHHHHHH	50.41	23663014
89	Phosphorylation	YSDTPPTSKSTVEEL CCCCCCCCHHHHHHH	30.31	23663014
177	Phosphorylation	VYFDDCMSIHQCKIS EEECCCCCCCCCEEE	24.21	-
184	Phosphorylation	SIHQCKISCESMGAS CCCCCEEECCCCCCC	9.42	-
192	Ubiquitination	CESMGASKYRWFHNA CCCCCCCHHHHHHHH	38.00	29967540
214	Ubiquitination	ECIDYGSKTVKCMNC HHHCCCCCEEEEECC	53.63	-
217	Ubiquitination	DYGSKTVKCMNCMF- CCCCCEEEEECCCC-	32.76	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TWSG1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TWSG1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TWSG1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BMP4_HUMAN	BMP4	physical	11260715
CHRD_HUMAN	CHRD	physical	11260715

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.