| UniProt ID | CHRD_HUMAN | |
|---|---|---|
| UniProt AC | Q9H2X0 | |
| Protein Name | Chordin | |
| Gene Name | CHRD | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 955 | |
| Subcellular Localization | Secreted. | |
| Protein Description | Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity).. | |
| Protein Sequence | MPSLPAPPAPLLLLGLLLLGSRPARGAGPEPPVLPIRSEKEPLPVRGAAGCTFGGKVYALDETWHPDLGEPFGVMRCVLCACEAPQWGRRTRGPGRVSCKNIKPECPTPACGQPRQLPGHCCQTCPQERSSSERQPSGLSFEYPRDPEHRSYSDRGEPGAEERARGDGHTDFVALLTGPRSQAVARARVSLLRSSLRFSISYRRLDRPTRIRFSDSNGSVLFEHPAAPTQDGLVCGVWRAVPRLSLRLLRAEQLHVALVTLTHPSGEVWGPLIRHRALAAETFSAILTLEGPPQQGVGGITLLTLSDTEDSLHFLLLFRGLLEPRSGGLTQVPLRLQILHQGQLLRELQANVSAQEPGFAEVLPNLTVQEMDWLVLGELQMALEWAGRPGLRISGHIAARKSCDVLQSVLCGADALIPVQTGAAGSASLTLLGNGSLIYQVQVVGTSSEVVAMTLETKPQRRDQRTVLCHMAGLQPGGHTAVGICPGLGARGAHMLLQNELFLNVGTKDFPDGELRGHVAALPYCGHSARHDTLPVPLAGALVLPPVKSQAAGHAWLSLDTHCHLHYEVLLAGLGGSEQGTVTAHLLGPPGTPGPRRLLKGFYGSEAQGVVKDLEPELLRHLAKGMASLMITTKGSPRGELRGQVHIANQCEVGGLRLEAAGAEGVRALGAPDTASAAPPVVPGLPALAPAKPGGPGRPRDPNTCFFEGQQRPHGARWAPNYDPLCSLCTCQRRTVICDPVVCPPPSCPHPVQAPDQCCPVCPEKQDVRDLPGLPRSRDPGEGCYFDGDRSWRAAGTRWHPVVPPFGLIKCAVCTCKGGTGEVHCEKVQCPRLACAQPVRVNPTDCCKQCPVGSGAHPQLGDPMQADGPRGCRFAGQWFPESQSWHPSVPPFGEMSCITCRCGAGVPHCERDDCSLPLSCGSGKESRCCSRCTAHRRPAPETRTDPELEKEAEGS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 91 | Phosphorylation | APQWGRRTRGPGRVS CCCCCCCCCCCCCCC | 38.32 | 24719451 | |
| 130 | Phosphorylation | QTCPQERSSSERQPS CCCCCCCCCCCCCCC | 37.15 | - | |
| 131 | Phosphorylation | TCPQERSSSERQPSG CCCCCCCCCCCCCCC | 42.30 | - | |
| 132 | Phosphorylation | CPQERSSSERQPSGL CCCCCCCCCCCCCCC | 37.74 | - | |
| 190 | Phosphorylation | AVARARVSLLRSSLR HHHHHHHHHHHHHHC | 19.01 | 30576142 | |
| 194 | Phosphorylation | ARVSLLRSSLRFSIS HHHHHHHHHHCEEEE | 33.42 | 21406692 | |
| 195 | Phosphorylation | RVSLLRSSLRFSISY HHHHHHHHHCEEEEE | 19.68 | 20068231 | |
| 199 | Phosphorylation | LRSSLRFSISYRRLD HHHHHCEEEEEECCC | 12.28 | 30576142 | |
| 217 | N-linked_Glycosylation | RIRFSDSNGSVLFEH EEEEECCCCCEEEEC | 52.31 | UniProtKB CARBOHYD | |
| 245 | Phosphorylation | WRAVPRLSLRLLRAE HCHHCHHHHHHHHHH | 16.84 | 23532336 | |
| 260 | Phosphorylation | QLHVALVTLTHPSGE HHEEEEEEEECCCCC | 27.13 | 25278378 | |
| 262 | Phosphorylation | HVALVTLTHPSGEVW EEEEEEEECCCCCCC | 23.52 | 25278378 | |
| 265 | Phosphorylation | LVTLTHPSGEVWGPL EEEEECCCCCCCHHH | 39.73 | 25278378 | |
| 329 (in isoform 4) | Phosphorylation | - | 3.27 | 26270265 | |
| 330 (in isoform 4) | Phosphorylation | - | 30.69 | 26270265 | |
| 335 (in isoform 4) | Phosphorylation | - | 20.62 | 26270265 | |
| 351 | N-linked_Glycosylation | LLRELQANVSAQEPG HHHHHHHCCCCCCCC | 18.47 | UniProtKB CARBOHYD | |
| 365 | N-linked_Glycosylation | GFAEVLPNLTVQEMD CHHHHCCCCEEEEEC | 44.15 | UniProtKB CARBOHYD | |
| 434 | N-linked_Glycosylation | ASLTLLGNGSLIYQV EEEEEECCCCEEEEE | 36.53 | UniProtKB CARBOHYD | |
| 674 | Phosphorylation | RALGAPDTASAAPPV HHCCCCCCCCCCCCC | 22.81 | 22210691 | |
| 676 | Phosphorylation | LGAPDTASAAPPVVP CCCCCCCCCCCCCCC | 27.36 | 22210691 | |
| 942 | Phosphorylation | HRRPAPETRTDPELE CCCCCCCCCCCHHHH | 37.50 | 18452278 | |
| 944 | Phosphorylation | RPAPETRTDPELEKE CCCCCCCCCHHHHHH | 64.42 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CHRD_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CHRD_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CHRD_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SMAD3_HUMAN | SMAD3 | physical | 21988832 | |
| PAR1_HUMAN | F2R | physical | 21988832 | |
| HRG_HUMAN | HRG | physical | 21988832 | |
| NR0B2_HUMAN | NR0B2 | physical | 21988832 | |
| SPY2_HUMAN | SPRY2 | physical | 25416956 | |
| KRA92_HUMAN | KRTAP9-2 | physical | 25416956 | |
| KRA42_HUMAN | KRTAP4-2 | physical | 25416956 | |
| CTSR1_HUMAN | CATSPER1 | physical | 25416956 | |
| KR107_HUMAN | KRTAP10-7 | physical | 25416956 | |
| KR109_HUMAN | KRTAP10-9 | physical | 25416956 | |
| KR101_HUMAN | KRTAP10-1 | physical | 25416956 | |
| KR108_HUMAN | KRTAP10-8 | physical | 25416956 | |
| KR103_HUMAN | KRTAP10-3 | physical | 25416956 | |
| NT2NL_HUMAN | NOTCH2NL | physical | 25416956 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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