SNX19_HUMAN - dbPTM
SNX19_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SNX19_HUMAN
UniProt AC Q92543
Protein Name Sorting nexin-19
Gene Name SNX19
Organism Homo sapiens (Human).
Sequence Length 992
Subcellular Localization Early endosome membrane
Peripheral membrane protein
Cytoplasmic side . Cytoplasmic vesicle membrane
Peripheral membrane protein
Cytoplasmic side .
Protein Description Plays a role in intracellular vesicle trafficking and exocytosis. [PubMed: 24843546 May play a role in maintaining insulin-containing dense core vesicles in pancreatic beta-cells and in preventing their degradation. May play a role in insulin secretion]
Protein Sequence MKTETVPPFQETPAGSSCHLNNLLSSRKLMAVGVLLGWLLVIHLLVNVWLLCLLSALLVVLGGWLGSSLAGVASGRLHLERFIPLATCPPCPEAERQLEREINRTIQMIIRDFVLSWYRSVSQEPAFEEEMEAAMKGLVQELRRRMSVMDSHAVAQSVLTLCGCHLQSYIQAKEATAGKNGPVEPSHLWEAYCRATAPHPAVHSPSAEVTYTRGVVNLLLQGLVPKPHLETRTGRHVVVELITCNVILPLISRLSDPDWIHLVLVGIFSKARDPAPCPASAPEQPSVPTSLPLIAEVEQLPEGRASPVAAPVFLSYSEPEGSAGPSPEVEEGHEAVEGDLGGMCEERKVGNNSSHFLQPNVRGPLFLCEDSELESPLSELGKETIMLMTPGSFLSDRIQDALCALESSQALEPKDGEASEGAEAEEGPGTETETGLPVSTLNSCPEIHIDTADKEIEQGDVTASVTALLEGPEKTCPSRPSCLEKDLTNDVSSLDPTLPPVLLSSSPPGPLSSATFSFEPLSSPDGPVIIQNLRITGTITAREHSGTGFHPYTLYTVKYETALDGENSSGLQQLAYHTVNRRYREFLNLQTRLEEKPDLRKFIKNVKGPKKLFPDLPLGNMDSDRVEARKSLLESFLKQLCAIPEIANSEEVQEFLALNTDARIAFVKKPFMVSRIDKMVVSAIVDTLKTAFPRSEPQSPTEELSEAETESKPQTEGKKASKSRLRFSSSKISPALSVTEAQDKILYCLQEGNVESETLSMSAMESFIEKQTKLLEMQPTKAPEKDPEQPPKGRVDSCVSDAAVPAQDPSNSDPGTETELADTALDLLLLLLTEQWKWLCTENMQKFLRLIFGTLVQRWLEVQVANLTSPQRWVQYLLLLQESIWPGGVLPKFPRPVRTQEQKLAAEKQALQSLMGVLPDLVVEILGVNKCRLSWGLVLESLQQPLINRHLIYCLGDIILEFLDLSASVEESAATTSASDTPGNSKRMGVSS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MKTETVPPFQ
-----CCCCCCCCCC		35.2724719451
17PhosphorylationQETPAGSSCHLNNLL
CCCCCCCCHHHHHHH		12.4924719451
25PhosphorylationCHLNNLLSSRKLMAV
HHHHHHHHHHHHHHH		31.1224719451
26PhosphorylationHLNNLLSSRKLMAVG
HHHHHHHHHHHHHHH		33.1424719451
179UbiquitinationAKEATAGKNGPVEPS
HHHHHCCCCCCCCHH		57.16-
179UbiquitinationAKEATAGKNGPVEPS
HHHHHCCCCCCCCHH		57.16-
226UbiquitinationLLQGLVPKPHLETRT
HHCCCCCCCCCCCCC		37.27-
226UbiquitinationLLQGLVPKPHLETRT
HHCCCCCCCCCCCCC		37.27-
231PhosphorylationVPKPHLETRTGRHVV
CCCCCCCCCCCCEEE		39.63-
269PhosphorylationLVLVGIFSKARDPAP
HHHHHHHHCCCCCCC		24.3924719451
306PhosphorylationQLPEGRASPVAAPVF
HCCCCCCCCCCCCEE		20.6730108239
315O-linked_GlycosylationVAAPVFLSYSEPEGS
CCCCEEEECCCCCCC		18.3629351928
315PhosphorylationVAAPVFLSYSEPEGS
CCCCEEEECCCCCCC		18.3627251275
316PhosphorylationAAPVFLSYSEPEGSA
CCCEEEECCCCCCCC		21.1427251275
317PhosphorylationAPVFLSYSEPEGSAG
CCEEEECCCCCCCCC		43.2127251275
322PhosphorylationSYSEPEGSAGPSPEV
ECCCCCCCCCCCCCH		28.5227251275
353PhosphorylationERKVGNNSSHFLQPN
EEECCCCCCCCCCCC		29.2324719451
354PhosphorylationRKVGNNSSHFLQPNV
EECCCCCCCCCCCCC		22.0030108239
371PhosphorylationPLFLCEDSELESPLS
CEEEECCCCCCCCHH		23.0726657352
375PhosphorylationCEDSELESPLSELGK
ECCCCCCCCHHHCCC		43.7127732954
378PhosphorylationSELESPLSELGKETI
CCCCCCHHHCCCCEE		33.8727732954
419PhosphorylationEPKDGEASEGAEAEE
CCCCCCCCCCCCCCC		32.0626471730
430PhosphorylationEAEEGPGTETETGLP
CCCCCCCCCCCCCCC		42.7526471730
462PhosphorylationEIEQGDVTASVTALL
CHHHCCCEEEEEEHH		20.2526074081
464PhosphorylationEQGDVTASVTALLEG
HHCCCEEEEEEHHHC		15.6126074081
466PhosphorylationGDVTASVTALLEGPE
CCCEEEEEEHHHCCC		14.7526074081
492PhosphorylationKDLTNDVSSLDPTLP
CCCCCCHHHCCCCCC		28.2228348404
493PhosphorylationDLTNDVSSLDPTLPP
CCCCCHHHCCCCCCC		36.3228348404
497PhosphorylationDVSSLDPTLPPVLLS
CHHHCCCCCCCEEEC		52.1128348404
504PhosphorylationTLPPVLLSSSPPGPL
CCCCEEECCCCCCCC		25.3028348404
505PhosphorylationLPPVLLSSSPPGPLS
CCCEEECCCCCCCCC		47.0028348404
506PhosphorylationPPVLLSSSPPGPLSS
CCEEECCCCCCCCCC		31.5728348404
512PhosphorylationSSPPGPLSSATFSFE
CCCCCCCCCCEEEEC		22.5128348404
513PhosphorylationSPPGPLSSATFSFEP
CCCCCCCCCEEEECC		38.7228348404
515PhosphorylationPGPLSSATFSFEPLS
CCCCCCCEEEECCCC		23.0428348404
517PhosphorylationPLSSATFSFEPLSSP
CCCCCEEEECCCCCC		25.0928348404
540O-linked_GlycosylationLRITGTITAREHSGT
CEEEEEEEEEECCCC		21.3529351928
558AcetylationPYTLYTVKYETALDG
CEEEEEEEEEECCCC		29.5730592561
631PhosphorylationDRVEARKSLLESFLK
HHHHHHHHHHHHHHH		32.4127067055
635PhosphorylationARKSLLESFLKQLCA
HHHHHHHHHHHHHCC		35.5324719451
674PhosphorylationVKKPFMVSRIDKMVV
ECCCCHHCHHHHHHH		16.2520363803
682PhosphorylationRIDKMVVSAIVDTLK
HHHHHHHHHHHHHHH		10.8120363803
687PhosphorylationVVSAIVDTLKTAFPR
HHHHHHHHHHHHCCC		21.1820363803
690PhosphorylationAIVDTLKTAFPRSEP
HHHHHHHHHCCCCCC		36.3230177828
695PhosphorylationLKTAFPRSEPQSPTE
HHHHCCCCCCCCCCH		54.5928450419
699PhosphorylationFPRSEPQSPTEELSE
CCCCCCCCCCHHHHH		44.5028355574
701PhosphorylationRSEPQSPTEELSEAE
CCCCCCCCHHHHHHH		47.5423927012
705PhosphorylationQSPTEELSEAETESK
CCCCHHHHHHHHCCC		37.7330108239
709PhosphorylationEELSEAETESKPQTE
HHHHHHHHCCCCCCC		53.2430108239
711PhosphorylationLSEAETESKPQTEGK
HHHHHHCCCCCCCCC		57.9923927012
715PhosphorylationETESKPQTEGKKASK
HHCCCCCCCCCHHCH		56.0623927012
728PhosphorylationSKSRLRFSSSKISPA
CHHHHHCCCCCCCCC		27.5427251275
731UbiquitinationRLRFSSSKISPALSV
HHHCCCCCCCCCCCC		49.50-
731UbiquitinationRLRFSSSKISPALSV
HHHCCCCCCCCCCCC		49.502190698
733PhosphorylationRFSSSKISPALSVTE
HCCCCCCCCCCCCCH		14.0922199227
737PhosphorylationSKISPALSVTEAQDK
CCCCCCCCCCHHHHH		29.1526699800
739PhosphorylationISPALSVTEAQDKIL
CCCCCCCCHHHHHHH		23.4026699800
913PhosphorylationAEKQALQSLMGVLPD
HHHHHHHHHHCCCHH		22.6026074081
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SNX19_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SNX19_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SNX19_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SNX19_HUMAN !!
Drug and Disease Associations
Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SNX19_HUMAN

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Related Literatures of Post-Translational Modification

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