GBG4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GBG4_HUMAN
• UniProt AC: P50150
• Protein Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
• Gene Name: GNG4
• Organism: Homo sapiens (Human).
• Sequence Length: 75
• Subcellular Localization: Cell membrane ; Lipid-anchor ; Cytoplasmic side .
• Protein Description: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction..
• Protein Sequence: MKEGMSNNSTTSISQARKAVEQLKMEACMDRVKVSQAAADLLAYCEAHVREDPLIIPVPASENPFREKKFFCTIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MKEGMSNNSTTSI --CCCCCCCCCCCCH	43.65	27732954
9	Phosphorylation	KEGMSNNSTTSISQA CCCCCCCCCCCHHHH	36.99	27732954
10	Phosphorylation	EGMSNNSTTSISQAR CCCCCCCCCCHHHHH	27.04	27732954
11	Phosphorylation	GMSNNSTTSISQARK CCCCCCCCCHHHHHH	24.71	27732954
12	Phosphorylation	MSNNSTTSISQARKA CCCCCCCCHHHHHHH	21.97	27732954
14	Phosphorylation	NNSTTSISQARKAVE CCCCCCHHHHHHHHH	19.97	27732954
24	Ubiquitination	RKAVEQLKMEACMDR HHHHHHHHHHHHHHH	34.10	-
72	Methylation	FREKKFFCTIL---- CCCCCCEEEEC----	2.32	7665596
72	Geranylgeranylation	FREKKFFCTIL---- CCCCCCEEEEC----	2.32	7665596
72	Geranylgeranylation	FREKKFFCTIL---- CCCCCCEEEEC----	2.32	7665596

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GBG4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GBG4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GBG4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GNB5_HUMAN	GNB5	physical	8636150
GBB_SCHPO	git5	physical	16884933
GBB1_HUMAN	GNB1	physical	8636150
GBB2_HUMAN	GNB2	physical	8636150
GBB3_HUMAN	GNB3	physical	8636150
GBB4_HUMAN	GNB4	physical	8636150
GBB1_HUMAN	GNB1	physical	19168127
GBB2_HUMAN	GNB2	physical	19168127
GBB3_HUMAN	GNB3	physical	19168127
TFP11_HUMAN	TFIP11	physical	25416956
USBP1_HUMAN	USHBP1	physical	25416956
GNAI3_HUMAN	GNAI3	physical	28514442
GNAI1_HUMAN	GNAI1	physical	28514442
GNAS3_HUMAN	GNAS	physical	28514442
GNAS2_HUMAN	GNAS	physical	28514442
ALEX_HUMAN	GNAS	physical	28514442
GNAS1_HUMAN	GNAS	physical	28514442
GNAI2_HUMAN	GNAI2	physical	28514442
GBB4_HUMAN	GNB4	physical	28514442
MSPD2_HUMAN	MOSPD2	physical	28514442
GNAQ_HUMAN	GNAQ	physical	28514442
PHLP_HUMAN	PDCL	physical	28514442
GBB1_HUMAN	GNB1	physical	28514442
GNA13_HUMAN	GNA13	physical	28514442
GNA11_HUMAN	GNA11	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Methylation

"Isolation of cDNA clones encoding eight different human G proteingamma subunits, including three novel forms designated the gamma 4,gamma 10, and gamma 11 subunits.";
Ray K., Kunsch C., Bonner L.M., Robishaw J.D.;
J. Biol. Chem. 270:21765-21771(1995).
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ISOPRENYLATION AT CYS-72, AND METHYLATIONAT CYS-72.
PubMed: 7665596

Prenylation

"Isolation of cDNA clones encoding eight different human G proteingamma subunits, including three novel forms designated the gamma 4,gamma 10, and gamma 11 subunits.";
Ray K., Kunsch C., Bonner L.M., Robishaw J.D.;
J. Biol. Chem. 270:21765-21771(1995).
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ISOPRENYLATION AT CYS-72, AND METHYLATIONAT CYS-72.
PubMed: 7665596