RCAN3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RCAN3_HUMAN
• UniProt AC: Q9UKA8
• Protein Name: Calcipressin-3
• Gene Name: RCAN3
• Organism: Homo sapiens (Human).
• Sequence Length: 241
• Protein Description: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By similarity)..
• Protein Sequence: MLRDTMKSWNDSQSDLCSTDQEEEEEMIFGENEDDLDEMMDLSDLPTSLFACSVHEAVFEAREQKERFEALFTIYDDQVTFQLFKSFRRVRINFSKPEAAARARIELHETDFNGQKLKLYFAQVQMSGEVRDKSYLLPPQPVKQFLISPPASPPVGWKQSEDAMPVINYDLLCAVSKLGPGEKYELHAGTESTPSVVVHVCESETEEEEETKNPKQKIAQTRRPDPPTAALNEPQTFDCAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
96	Ubiquitination	RVRINFSKPEAAARA EEEEECCCHHHHHHH	42.62	-
135	Phosphorylation	GEVRDKSYLLPPQPV CCCCCCCEECCCCCC	20.28	27642862
148	Phosphorylation	PVKQFLISPPASPPV CCEEEEECCCCCCCC	27.29	22167270
152	Phosphorylation	FLISPPASPPVGWKQ EEECCCCCCCCCCCC	35.19	12809556
177	Ubiquitination	DLLCAVSKLGPGEKY HHHHHHHCCCCCCCE	51.36	-
184	Phosphorylation	KLGPGEKYELHAGTE CCCCCCCEEEECCCC	21.30	29978859
190	Phosphorylation	KYELHAGTESTPSVV CEEEECCCCCCCEEE	27.78	29978859
192	Phosphorylation	ELHAGTESTPSVVVH EEECCCCCCCEEEEE	45.52	29978859
193	Phosphorylation	LHAGTESTPSVVVHV EECCCCCCCEEEEEE	17.22	29978859
195	Phosphorylation	AGTESTPSVVVHVCE CCCCCCCEEEEEEEC	27.86	28122231
203	Phosphorylation	VVVHVCESETEEEEE EEEEEECCCCHHHHH	44.70	27422710
205	Phosphorylation	VHVCESETEEEEETK EEEECCCCHHHHHHC	58.96	30576142
211	Phosphorylation	ETEEEEETKNPKQKI CCHHHHHHCCHHHHH	39.13	30576142
222	Dimethylation	KQKIAQTRRPDPPTA HHHHHHHCCCCCCCC	35.73	-
222	Methylation	KQKIAQTRRPDPPTA HHHHHHHCCCCCCCC	35.73	24390305
228	Phosphorylation	TRRPDPPTAALNEPQ HCCCCCCCCCCCCCC	29.92	26503892
236	Phosphorylation	AALNEPQTFDCAL-- CCCCCCCCCCCCC--	31.96	26503892

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RCAN3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RCAN3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RCAN3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TNNI3_HUMAN	TNNI3	physical	16516408
PP2BB_HUMAN	PPP3CB	physical	26186194
PP2BC_HUMAN	PPP3CC	physical	26186194
PP2BA_HUMAN	PPP3CA	physical	26186194
ARMT1_HUMAN	C6orf211	physical	26186194
CDK4_HUMAN	CDK4	physical	26186194
OBSL1_HUMAN	OBSL1	physical	26186194
CANB1_HUMAN	PPP3R1	physical	26186194
SMYD3_HUMAN	SMYD3	physical	26186194
GRB10_HUMAN	GRB10	physical	25814554
PP2BC_HUMAN	PPP3CC	physical	28514442
PP2BA_HUMAN	PPP3CA	physical	28514442
CANB1_HUMAN	PPP3R1	physical	28514442
ARMT1_HUMAN	C6orf211	physical	28514442
PP2BB_HUMAN	PPP3CB	physical	28514442
SMYD3_HUMAN	SMYD3	physical	28514442
CDK4_HUMAN	CDK4	physical	28514442
OBSL1_HUMAN	OBSL1	physical	28514442
PLSI_HUMAN	PLS1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148 AND SER-152, ANDMASS SPECTROMETRY.
PubMed: 17081983