TF2L1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TF2L1_HUMAN
• UniProt AC: Q9NZI6
• Protein Name: Transcription factor CP2-like protein 1
• Gene Name: TFCP2L1
• Organism: Homo sapiens (Human).
• Sequence Length: 479
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs). [PubMed: 25215486]
• Protein Sequence: MLFWHTQPEHYNQHNSGSYLRDVLALPIFKQEEPQLSPENEARLPPLQYVLCAATSPAVKLHEETLTYLNQGQSYEIRLLENRKLGDFQDLNTKYVKSIIRVVFHDRRLQYTEHQQLEGWRWSRPGDRILDIDIPLSVGILDPRASPTQLNAVEFLWDPAKRASAFIQVHCISTEFTPRKHGGEKGVPFRVQIDTFKQNENGEYTEHLHSASCQIKVFKPKGADRKQKTDREKMEKRTAQEKEKYQPSYETTILTECSPWPDVAYQVNSAPSPSYNGSPNSFGLGEGNASPTHPVEALPVGSDHLLPSASIQDAQQWLHRNRFSQFCRLFASFSGADLLKMSRDDLVQICGPADGIRLFNAIKGRNVRPKMTIYVCQELEQNRVPLQQKRDGSGDSNLSVYHAIFLEELTTLELIEKIANLYSISPQHIHRVYRQGPTGIHVVVSNEMVQNFQDESCFVLSTIKAESNDGYHIILKCGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Sumoylation	VLALPIFKQEEPQLS HHHHEECCCCCCCCC	58.48	-
30	Sumoylation	VLALPIFKQEEPQLS HHHHEECCCCCCCCC	58.48	-
30	Ubiquitination	VLALPIFKQEEPQLS HHHHEECCCCCCCCC	58.48	-
37	Phosphorylation	KQEEPQLSPENEARL CCCCCCCCCCCCCCC	25.56	28355574
111	Phosphorylation	FHDRRLQYTEHQQLE HCCCCCCCEECHHCC	20.77	20068231
112	Phosphorylation	HDRRLQYTEHQQLEG CCCCCCCEECHHCCC	17.65	20068231
137	Phosphorylation	LDIDIPLSVGILDPR EEEECCEEEEECCCC	16.97	24719451
146	Phosphorylation	GILDPRASPTQLNAV EECCCCCCHHHCCHH	29.74	28348404
148	Phosphorylation	LDPRASPTQLNAVEF CCCCCCHHHCCHHHH	43.10	24719451
173	Phosphorylation	FIQVHCISTEFTPRK EEEEEEEECCCCCCC	27.55	24719451
174	Phosphorylation	IQVHCISTEFTPRKH EEEEEEECCCCCCCC	18.40	28348404
177	Phosphorylation	HCISTEFTPRKHGGE EEEECCCCCCCCCCC	18.89	21857030
185	Ubiquitination	PRKHGGEKGVPFRVQ CCCCCCCCCCCEEEE	69.36	-
195	Phosphorylation	PFRVQIDTFKQNENG CEEEEEECEEECCCC	34.07	-
221	Ubiquitination	QIKVFKPKGADRKQK EEEEECCCCCCCCCC	68.28	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
177	T	Phosphorylation	Kinase	CDK1	P06493	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TF2L1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TF2L1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TF2L1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.