F149B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F149B_HUMAN
• UniProt AC: Q96BN6
• Protein Name: Protein FAM149B1
• Gene Name: FAM149B1
• Organism: Homo sapiens (Human).
• Sequence Length: 582
• Protein Sequence: MISRYTRKAVPQSLELKGITKHALNHHPPPEKLEEISPTSDSHEKDTSSQSKSDITRESSFTSADTGNSLSAFPSYTGAGISTEGSSDFSWGYGELDQNATEKVQTMFTAIDELLYEQKLSVHTKSLQEECQQWTASFPHLRILGRQIITPSEGYRLYPRSPSAVSASYETTLSQERDSTIFGIRGKKLHFSSSYAHKASSIAKSSSFCSMERDEEDSIIVSEGIIEEYLAFDHIDIEEGFHGKKSEAATEKQKLGYPPIAPFYCMKEDVLAYVFDSVWCKVVSCMEQLTRSHWEGFASDDESNVAVTRPDSESSCVLSELHPLVLPRVPQSKVLYITSNPMSLCQASRHQPNVNDLLVHGMPLQPRNLSLMDKLLDLDDKLLMRPGSSTILSTRNWPNRAVEFSTSSLSYTVQSTRRRNPPPRTLHPISTSHSCAETPRSVEEILRGARVPVAPDSLSSPSPTPLSRNNLLPPIGTAEVEHVSTVGPQRQMKPHGDSSRAQSAVVDEPNYQQPQERLLLPDFFPRPNTTQSFLLDTQYRRSCAVEYPHQARPGRGSAGPQLHGSTKSQSGGRPVSRTRQGP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MISRYTRKAVPQS --CCCCCCCCCCCCC	25.28	-
37	Phosphorylation	PEKLEEISPTSDSHE HHHHHHCCCCCCCCC	25.96	29255136
39	Phosphorylation	KLEEISPTSDSHEKD HHHHCCCCCCCCCCC	38.07	29255136
40	Phosphorylation	LEEISPTSDSHEKDT HHHCCCCCCCCCCCC	40.26	29255136
42	Phosphorylation	EISPTSDSHEKDTSS HCCCCCCCCCCCCCC	33.06	27251275
116	Phosphorylation	TAIDELLYEQKLSVH HHHHHHHHHHHCCHH	29.01	19413330
135	Phosphorylation	QEECQQWTASFPHLR HHHHHHHHHHCCCCE	14.21	23401153
137	Phosphorylation	ECQQWTASFPHLRIL HHHHHHHHCCCCEEE	31.75	23401153
150	Phosphorylation	ILGRQIITPSEGYRL EECEEEECCCCCCCC	23.53	24043423
152	Phosphorylation	GRQIITPSEGYRLYP CEEEECCCCCCCCCC	34.70	24043423
155	Phosphorylation	IITPSEGYRLYPRSP EECCCCCCCCCCCCH	8.06	24043423
158	Phosphorylation	PSEGYRLYPRSPSAV CCCCCCCCCCCHHCC	6.39	24043423
166	Phosphorylation	PRSPSAVSASYETTL CCCHHCCCEEEECCC	15.94	24275569
168	Phosphorylation	SPSAVSASYETTLSQ CHHCCCEEEECCCCC	18.92	24275569
192	Phosphorylation	RGKKLHFSSSYAHKA CCCEEEECCCHHHHH	13.97	-
193	Phosphorylation	GKKLHFSSSYAHKAS CCEEEECCCHHHHHH	26.82	-
200	Phosphorylation	SSYAHKASSIAKSSS CCHHHHHHHHHHCCC	27.38	-
201	Phosphorylation	SYAHKASSIAKSSSF CHHHHHHHHHHCCCC	31.27	-
257	Phosphorylation	TEKQKLGYPPIAPFY HHHHHHCCCCCCCCE	19.10	-
264	Phosphorylation	YPPIAPFYCMKEDVL CCCCCCCEECHHHHH	7.20	-
299	Phosphorylation	SHWEGFASDDESNVA HHHCCCCCCCCCCEE	43.25	28348404
303	Phosphorylation	GFASDDESNVAVTRP CCCCCCCCCEEEECC	43.53	28348404
340 (in isoform 2)	Phosphorylation	-	27.87	22210691
389	Phosphorylation	LLMRPGSSTILSTRN EECCCCCCCEEECCC	25.94	30631047
485	Phosphorylation	AEVEHVSTVGPQRQM EEEEEEEECCCCCCC	28.52	22210691
529	Phosphorylation	DFFPRPNTTQSFLLD CCCCCCCCCCHHHHC	28.97	29978859
530	Phosphorylation	FFPRPNTTQSFLLDT CCCCCCCCCHHHHCC	28.93	29978859
532	Phosphorylation	PRPNTTQSFLLDTQY CCCCCCCHHHHCCCH	18.77	29978859
537	Phosphorylation	TQSFLLDTQYRRSCA CCHHHHCCCHHHHCC	27.72	29978859
539	Phosphorylation	SFLLDTQYRRSCAVE HHHHCCCHHHHCCCC	15.30	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of F149B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F149B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F149B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BROMI_HUMAN	TBC1D32	physical	26186194
BROMI_HUMAN	TBC1D32	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.