SPX3_HUMAN - dbPTM
SPX3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SPX3_HUMAN
UniProt AC Q8NCC5
Protein Name Sugar phosphate exchanger 3
Gene Name SLC37A3
Organism Homo sapiens (Human).
Sequence Length 494
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description
Protein Sequence MAWPNVFQRGSLLSQFSHHHVVVFLLTFFSYSLLHASRKTFSNVKVSISEQWTPSAFNTSVELPVEIWSSNHLFPSAEKATLFLGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWLRFYNKWLYCCLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVFGLWSACASVGNILGACLASSVLQYGYEYAFLVTASVQFAGGIVIFFGLLVSPEEIGLSGIEAEENFEEDSHRPLINGGENEDEYEPNYSIQDDSSVAQVKAISFYQACCLPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFGWKEAEADKLSIWYDVGGIIGGTLQGFISDVLQKRAPVLALSLLLAVGSLIGYSRSPNDKSINALLMTVTGFFIGGPSNMISSAISADLGRQELIQRSSEALATVTGIVDGSGSIGAAVGQYLVSLIRDKLGWMWVFYFFILMTSCTIVFISPLIVREIFSLVLRRQAHILRE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
58N-linked_GlycosylationQWTPSAFNTSVELPV
CCCCCCCCCCEEECE		31.03UniProtKB CARBOHYD
266N-linked_GlycosylationNEDEYEPNYSIQDDS
CCCCCCCCCCCCCCC		31.11UniProtKB CARBOHYD
387 (in isoform 3)Phosphorylation-2.22-
395 (in isoform 3)Phosphorylation-6.11-
422 (in isoform 3)Phosphorylation-12.4024043423
424 (in isoform 3)Phosphorylation-13.6824043423
425 (in isoform 3)Phosphorylation-21.3224043423
426 (in isoform 3)Phosphorylation-3.7224043423
434 (in isoform 3)Phosphorylation-28.8925627689
437 (in isoform 3)Phosphorylation-14.8022210691
439 (in isoform 3)Phosphorylation-10.7622210691
459PhosphorylationLGWMWVFYFFILMTS
HHHHHHHHHHHHHHH		6.4825072903
465PhosphorylationFYFFILMTSCTIVFI
HHHHHHHHHCCCHHC		19.7325072903
466PhosphorylationYFFILMTSCTIVFIS
HHHHHHHHCCCHHCC		8.6925072903
468PhosphorylationFILMTSCTIVFISPL
HHHHHHCCCHHCCHH		21.6825072903
473PhosphorylationSCTIVFISPLIVREI
HCCCHHCCHHHHHHH		11.3725072903
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SPX3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SPX3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SPX3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ZN177_HUMANZNF177physical
21988832
SPRY7_HUMANSPRYD7physical
28514442
ARAID_HUMANATRAIDphysical
28514442
CAV1_HUMANCAV1physical
28514442
CLH2_HUMANCLTCL1physical
28514442
APOB_HUMANAPOBphysical
28514442
S2546_HUMANSLC25A46physical
28514442
MTX3_HUMANMTX3physical
28514442
RN5A_HUMANRNASELphysical
28514442
GCP2_HUMANTUBGCP2physical
28514442
AT12A_HUMANATP12Aphysical
28514442
NB5R3_HUMANCYB5R3physical
28514442
TIM14_HUMANDNAJC19physical
28514442
ARL15_HUMANARL15physical
28514442
KMCP1_HUMANSLC25A30physical
28514442
COT2_HUMANNR2F2physical
28514442
DAAM1_HUMANDAAM1physical
28514442
DHB7_HUMANHSD17B7physical
28514442
KC1G3_HUMANCSNK1G3physical
28514442
RASN_HUMANNRASphysical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SPX3_HUMAN

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Related Literatures of Post-Translational Modification

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