ARAID_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARAID_HUMAN
• UniProt AC: Q6UW56
• Protein Name: All-trans retinoic acid-induced differentiation factor
• Gene Name: ATRAID
• Organism: Homo sapiens (Human).
• Sequence Length: 229
• Subcellular Localization: Nucleus envelope . Cell membrane ; Single-pass membrane protein . Colocalizes with NELL1 on the nuclear envelope and the perinuclear region (PubMed:21723284).
• Protein Description: Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway..
• Protein Sequence: MAPHDPGSLTTLVPWAAALLLALGVERALALPEICTQCPGSVQNLSKVAFYCKTTRELMLHARCCLNQKGTILGLDLQNCSLEDPGPNFHQAHTTVIIDLQANPLKGDLANTFRGFTQLQTLILPQHVNCPGGINAWNTITSYIDNQICQGQKNLCNNTGDPEMCPENGSCVPDGPGLLQCVCADGFHGYKCMRQGSFSLLMFFGILGATTLSVSILLWATQRRKAKTS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	N-linked_Glycosylation	QCPGSVQNLSKVAFY CCCCCCCCHHHHHHE		UniProtKB CARBOHYD
53	Ubiquitination	SKVAFYCKTTRELML HHHHHEECCHHHHHH		27667366
79	N-linked_Glycosylation	ILGLDLQNCSLEDPG EEEEECCCCCCCCCC		UniProtKB CARBOHYD
94	O-linked_Glycosylation	PNFHQAHTTVIIDLQ CCCCCCCEEEEEEEC		OGP
108	Ubiquitination	QANPLKGDLANTFRG CCCCCCCCHHHHCCC		27667366
108 (in isoform 3)	Ubiquitination	-		-
157	N-linked_Glycosylation	QGQKNLCNNTGDPEM HCCCCCCCCCCCHHH		UniProtKB CARBOHYD
168	N-linked_Glycosylation	DPEMCPENGSCVPDG CHHHCCCCCCCCCCC		UniProtKB CARBOHYD
197	Phosphorylation	YKCMRQGSFSLLMFF HHHCCCCCCHHHHHH		24043423
199	Phosphorylation	CMRQGSFSLLMFFGI HCCCCCCHHHHHHHH		24043423
210	Phosphorylation	FFGILGATTLSVSIL HHHHHCHHHHHHHHH		24043423
211	Phosphorylation	FGILGATTLSVSILL HHHHCHHHHHHHHHH		24043423
213	Phosphorylation	ILGATTLSVSILLWA HHCHHHHHHHHHHHH		24043423
215	Phosphorylation	GATTLSVSILLWATQ CHHHHHHHHHHHHHH		24043423
221	Phosphorylation	VSILLWATQRRKAKT HHHHHHHHHHHHHCC		24043423

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARAID_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARAID_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARAID_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.