SPRY7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPRY7_HUMAN
• UniProt AC: Q5W111
• Protein Name: SPRY domain-containing protein 7
• Gene Name: SPRYD7
• Organism: Homo sapiens (Human).
• Sequence Length: 196
• Protein Sequence: MATSVLCCLRCCRDGGTGHIPLKEMPAVQLDTQHMGTDVVIVKNGRRICGTGGCLASAPLHQNKSYFEFKIQSTGIWGIGVATQKVNLNQIPLGRDMHSLVMRNDGALYHNNEEKNRLPANSLPQEGDVVGITYDHVELNVYLNGKNMHCPASGIRGTVYPVVYVDDSAILDCQFSEFYHTPPPGFEKILFEQQIF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATSVLCCL ------CCCEEEEHH	14.47	22223895
7	S-palmitoylation	-MATSVLCCLRCCRD -CCCEEEEHHHHCCC	1.60	29575903
8	S-palmitoylation	MATSVLCCLRCCRDG CCCEEEEHHHHCCCC	2.04	29575903
11	S-palmitoylation	SVLCCLRCCRDGGTG EEEEHHHHCCCCCCC	1.12	29575903
12	S-palmitoylation	VLCCLRCCRDGGTGH EEEHHHHCCCCCCCC	3.43	29575903
23	Ubiquitination	GTGHIPLKEMPAVQL CCCCCCHHHCCCEEE	46.76	-
76 (in isoform 2)	Ubiquitination	-	2.85	21906983
85	Ubiquitination	GIGVATQKVNLNQIP EEEEEECEECCCCCC	28.83	21890473
85	Ubiquitination	GIGVATQKVNLNQIP EEEEEECEECCCCCC	28.83	22053931
85 (in isoform 1)	Ubiquitination	-	28.83	21890473
109	Phosphorylation	MRNDGALYHNNEEKN HCCCCCCCCCCCCCC	11.28	27642862
115	Ubiquitination	LYHNNEEKNRLPANS CCCCCCCCCCCCCCC	40.98	2190698
115 (in isoform 1)	Ubiquitination	-	40.98	21890473
122	Phosphorylation	KNRLPANSLPQEGDV CCCCCCCCCCCCCCE	43.46	-
153	Phosphorylation	KNMHCPASGIRGTVY CCCCCCCCCCCCEEE	21.64	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPRY7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPRY7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPRY7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NHRF4_HUMAN	PDZD3	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.