| UniProt ID | NHRF4_HUMAN | |
|---|---|---|
| UniProt AC | Q86UT5 | |
| Protein Name | Na(+)/H(+) exchange regulatory cofactor NHE-RF4 | |
| Gene Name | PDZD3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 571 | |
| Subcellular Localization |
Cell membrane Peripheral membrane protein . Cytoplasm . Preferentially accumulates at the apical surface and ileal brush border of intestinal epithelial cells (PubMed:11950846, PubMed:19088451). |
|
| Protein Description | Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. [PubMed: 11950846 Stimulates SLC9A3 activity in the presence of elevated calcium ions] | |
| Protein Sequence | MVTPSPPGNHSLSLEAPRLHTASDLLGNHSLGLPLITALVGSRDRRGRVFSPVPVPLPTNPTTQHPTRQKLPSTLSGHRVCQAHGEPVLGLCPLLPLFCCPPHPPDPWSLERPRFCLLSKEEGKSFGFHLQQELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDVVEHEDYAVVVRRIRASSPRVLLTVLARHAHDVARAQLGEDAHLCPTLGPGVRPRLCHIVKDEGGFGFSVTHGNQGPFWLVLSTGGAAERAGVPPGARLLEVNGVSVEKFTHNQLTRKLWQSGQQVTLLVAGPEVEEQCRQLGLPLAAPLAEGWALPTKPRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVAVAGESVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLSPLLFLENTEAPASPRGSSSASLVETEDPSLEDTSVPSVPLGSRQCFLYPGPGGSYGFRLSCVASGPRLFISQVTPGGSAARAGLQVGDVILEVNGYPVGGQNDLERLQQLPEAEPPLCLKLAARSLRGLEAWIPPGAAEDWALASDLL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MVTPSPPGNH -----CCCCCCCCCC | 19.42 | 24043423 | |
| 5 | Phosphorylation | ---MVTPSPPGNHSL ---CCCCCCCCCCCC | 34.07 | 24043423 | |
| 11 | Phosphorylation | PSPPGNHSLSLEAPR CCCCCCCCCCCCCCC | 24.53 | 24043423 | |
| 13 | Phosphorylation | PPGNHSLSLEAPRLH CCCCCCCCCCCCCCC | 27.46 | 24043423 | |
| 185 | Phosphorylation | VRRIRASSPRVLLTV EEHHHCCCHHHHHHH | 18.75 | 28634120 | |
| 278 | Phosphorylation | GVSVEKFTHNQLTRK CEEEEEECHHHHHHH | 30.87 | 30622161 | |
| 384 | Phosphorylation | LVAVAGESVEGLGHE EEEEECCCCCCCCCH | 25.26 | 23532336 | |
| 395 | Phosphorylation | LGHEETVSRIQGQGS CCCHHHHHHHCCCCC | 30.96 | 22627094 | |
| 418 | Phosphorylation | PEADRFFSMVRLSPL CCHHHHHHHEECCCE | 17.41 | - | |
| 423 | Phosphorylation | FFSMVRLSPLLFLEN HHHHEECCCEEEEEC | 11.70 | 24275569 | |
| 436 | Phosphorylation | ENTEAPASPRGSSSA ECCCCCCCCCCCCCC | 17.67 | 28857561 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NHRF4_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NHRF4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NHRF4_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| GUC2C_HUMAN | GUCY2C | physical | 11950846 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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