RFX3_HUMAN - dbPTM
RFX3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RFX3_HUMAN
UniProt AC P48380
Protein Name Transcription factor RFX3
Gene Name RFX3
Organism Homo sapiens (Human).
Sequence Length 749
Subcellular Localization Nucleus .
Protein Description Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5) (By similarity). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes. [PubMed: 20148032 Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells]
Protein Sequence MQTSETGSDTGSTVTLQTSVASQAAVPTQVVQQVPVQQQVQQVQTVQQVQHVYPAQVQYVEGSDTVYTNGAIRTTTYPYTETQMYSQNTGGNYFDTQGSSAQVTTVVSSHSMVGTGGIQMGVTGGQLISSSGGTYLIGNSMENSGHSVTHTTRASPATIEMAIETLQKSDGLSTHRSSLLNSHLQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLDPVNAASFGKLIRSIFMGLRTRRLGTRGNSKYHYYGIRVKPDSPLNRLQEDMQYMAMRQQPMQQKQRYKPMQKVDGVADGFTGSGQQTGTSVEQTVIAQSQHHQQFLDASRALPEFGEVEISSLPDGTTFEDIKSLQSLYREHCEAILDVVVNLQFSLIEKLWQTFWRYSPSTPTDGTTITESSNLSEIESRLPKAKLITLCKHESILKWMCNCDHGMYQALVEILIPDVLRPIPSALTQAIRNFAKSLEGWLSNAMNNIPQRMIQTKVAAVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCDDNMVQRLETDFKMTLQQQSTLEQWAAWLDNVMMQALKPYEGRPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMGEFGDLNAVSPGNLDKDEGSEVESEMDEELDDSSEPQAKREKTELSQAFPVGCMQPVLETGVQPSLLNPIHSEHIVTSTQTIRQCSATGNTYTAV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
155PhosphorylationVTHTTRASPATIEMA
CCCCCCCCHHHHHHH		16.2729255136
158PhosphorylationTTRASPATIEMAIET
CCCCCHHHHHHHHHH		22.3629255136
165PhosphorylationTIEMAIETLQKSDGL
HHHHHHHHHHHCCCC		28.5123403867
169PhosphorylationAIETLQKSDGLSTHR
HHHHHHHCCCCCHHH		24.7724719451
173PhosphorylationLQKSDGLSTHRSSLL
HHHCCCCCHHHHHHH		27.9130108239
174PhosphorylationQKSDGLSTHRSSLLN
HHCCCCCHHHHHHHH		26.7630108239
198PhosphorylationYETAEGVSLPRSTLY
CCCCCCCCCCHHHHH		43.4424719451
227UbiquitinationVNAASFGKLIRSIFM
CCHHHHHHHHHHHHH		38.44-
257UbiquitinationHYYGIRVKPDSPLNR
EEEEEEECCCCHHHH		33.0029967540
260PhosphorylationGIRVKPDSPLNRLQE
EEEECCCCHHHHHHH		39.5525159151
374PhosphorylationVVVNLQFSLIEKLWQ
HHHHHHHHHHHHHHH		18.5724719451
382PhosphorylationLIEKLWQTFWRYSPS
HHHHHHHHHHHCCCC		17.3722468782
395PhosphorylationPSTPTDGTTITESSN
CCCCCCCCEEECCCC		20.17-
398PhosphorylationPTDGTTITESSNLSE
CCCCCEEECCCCHHH		27.94-
400PhosphorylationDGTTITESSNLSEIE
CCCEEECCCCHHHHH		18.8422468782
401PhosphorylationGTTITESSNLSEIES
CCEEECCCCHHHHHH		35.2422468782
423PhosphorylationITLCKHESILKWMCN
HHHCCCHHHHHHHHC		32.7024719451
490PhosphorylationQTKVAAVSAFAQTLR
HHHHHHHHHHHHHHH		16.9724670416
499PhosphorylationFAQTLRRYTSLNHLA
HHHHHHHHHCHHHHH		8.3423312004
500PhosphorylationAQTLRRYTSLNHLAQ
HHHHHHHHCHHHHHH		25.5623312004
501PhosphorylationQTLRRYTSLNHLAQA
HHHHHHHCHHHHHHH		20.4523312004
542S-palmitoylationQEQASWVCQCDDNMV
HHHHHEEEECCHHHH		2.4430127002
544S-palmitoylationQASWVCQCDDNMVQR
HHHEEEECCHHHHHH		6.3330127002
616PhosphorylationIRDLTLRSAASFGSF
HHHHHHHHHHHCCCH		31.1628122231
619PhosphorylationLTLRSAASFGSFHLI
HHHHHHHHCCCHHHH		29.8328122231
649PhosphorylationVAQATGETPIAVMGE
HHHHHCCCCEEEEEE		22.7227080861
664PhosphorylationFGDLNAVSPGNLDKD
CCCCCCCCCCCCCCC		25.3625849741
674PhosphorylationNLDKDEGSEVESEMD
CCCCCCCCCHHHHCC		36.1027499020
678PhosphorylationDEGSEVESEMDEELD
CCCCCHHHHCCHHCC		43.3127499020
687PhosphorylationMDEELDDSSEPQAKR
CCHHCCCCCCCHHHH		35.9521406692
688PhosphorylationDEELDDSSEPQAKRE
CHHCCCCCCCHHHHH		61.3621406692
739S-palmitoylationSTQTIRQCSATGNTY
CCCHHHHHCCCCCCE		1.8330127002
742PhosphorylationTIRQCSATGNTYTAV
HHHHHCCCCCCEEEC		18.05-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RFX3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RFX3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RFX3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TRAF2_HUMANTRAF2physical
16189514
RFX6_HUMANRFX6physical
16189514
TRIP6_HUMANTRIP6physical
25416956
SEC63_HUMANSEC63physical
26186194
PABP5_HUMANPABPC5physical
26186194
PABP5_HUMANPABPC5physical
28514442
MINY3_HUMANFAM188Aphysical
28514442
IGSF8_HUMANIGSF8physical
28514442
HDAC1_HUMANHDAC1physical
27173435
XYLT2_HUMANXYLT2physical
27173435
RTCB_HUMANRTCBphysical
27173435
MTA2_HUMANMTA2physical
27173435
PTOV1_HUMANPTOV1physical
27173435
DDX1_HUMANDDX1physical
27173435
BROMI_HUMANTBC1D32physical
27173435
VPS45_HUMANVPS45physical
27173435
TAF6L_HUMANTAF6Lphysical
27173435
MBD2_HUMANMBD2physical
27173435
CDK20_HUMANCDK20physical
27173435
ACAD9_HUMANACAD9physical
27173435
HDAC2_HUMANHDAC2physical
27173435
TMED4_HUMANTMED4physical
27173435
FOXJ1_HUMANFOXJ1physical
27173435
CFA20_HUMANCFAP20physical
27173435
PLK1_HUMANPLK1physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RFX3_HUMAN

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Related Literatures of Post-Translational Modification

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