PTOV1_HUMAN - dbPTM
PTOV1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PTOV1_HUMAN
UniProt AC Q86YD1
Protein Name Prostate tumor-overexpressed gene 1 protein
Gene Name PTOV1
Organism Homo sapiens (Human).
Sequence Length 416
Subcellular Localization Cell membrane. Cytoplasm, perinuclear region. Nucleus. Translocates from the cytoplasm to the nucleus at the onset of S-phase. Also localizes to lipid rafts.
Protein Description May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation..
Protein Sequence MVRPRRAPYRSGAGGPLGGRGRPPRPLVVRAVRSRSWPASPRGPQPPRIRARSAPPMEGARVFGALGPIGPSSPGLTLGGLAVSEHRLSNKLLAWSGVLEWQEKRRPYSDSTAKLKRTLPCQAYVNQGENLETDQWPQKLIMQLIPQQLLTTLGPLFRNSQLAQFHFTNRDCDSLKGLCRIMGNGFAGCMLFPHISPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVSAIRQVITTRKQAVGPGGVNSGPVQIVNNKFLAWSGVMEWQEPRPEPNSRSKRWLPSHVYVNQGEILRTEQWPRKLYMQLIPQQLLTTLVPLFRNSRLVQFHFTKDLETLKSLCRIMDNGFAGCVHFSYKASCEIRVLMLLYSSEKKIFIGLIPHDQGNFVNGIRRVIANQQQVLQRNLEQEQQQRGMGG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationPRRAPYRSGAGGPLG
CCCCCCCCCCCCCCC		27.4428555341
23 (in isoform 3)Ubiquitination-31.8821890473
34PhosphorylationLVVRAVRSRSWPASP
EEEEEHHHCCCCCCC		24.8630266825
36PhosphorylationVRAVRSRSWPASPRG
EEEHHHCCCCCCCCC		38.3623927012
40PhosphorylationRSRSWPASPRGPQPP
HHCCCCCCCCCCCCC		15.8530266825
48 (in isoform 3)Ubiquitination-37.3921890473
53PhosphorylationPPRIRARSAPPMEGA
CCCCCCCCCCCCCCC		44.1123401153
59 (in isoform 2)Ubiquitination-16.6621890473
72 (in isoform 2)Ubiquitination-43.9121890473
72PhosphorylationALGPIGPSSPGLTLG
ECCCCCCCCCCCCCC		43.9128450419
73PhosphorylationLGPIGPSSPGLTLGG
CCCCCCCCCCCCCCC		26.5630175587
77PhosphorylationGPSSPGLTLGGLAVS
CCCCCCCCCCCCEEC		29.3128464451
84PhosphorylationTLGGLAVSEHRLSNK
CCCCCEECCHHHHCC		23.2927251275
89PhosphorylationAVSEHRLSNKLLAWS
EECCHHHHCCCHHHH		31.6928674151
91UbiquitinationSEHRLSNKLLAWSGV
CCHHHHCCCHHHHHH		41.3121890473
91 (in isoform 1)Ubiquitination-41.3121890473
104 (in isoform 1)Ubiquitination-38.3121890473
104UbiquitinationGVLEWQEKRRPYSDS
HHHHHHHHCCCCCCC		38.3121890473
114UbiquitinationPYSDSTAKLKRTLPC
CCCCCHHHHHCCCCC		55.41-
116UbiquitinationSDSTAKLKRTLPCQA
CCCHHHHHCCCCCCE		42.50-
142 (in isoform 3)Ubiquitination-3.7221890473
144 (in isoform 2)Ubiquitination-3.2321890473
148 (in isoform 3)Ubiquitination-32.8421890473
176 (in isoform 1)Ubiquitination-54.5121890473
176UbiquitinationNRDCDSLKGLCRIMG
CCCHHHHHHHHHHHC		54.5121906983
180 (in isoform 2)Ubiquitination-27.2821890473
184 (in isoform 3)Ubiquitination-25.6521890473
205 (in isoform 2)Ubiquitination-3.3821890473
212UbiquitinationLLYSSKKKIFMGLIP
HHHHCCCEEEEECCC		44.9321890473
212 (in isoform 1)Ubiquitination-44.9321890473
220PhosphorylationIFMGLIPYDQSGFVS
EEEECCCCCCCHHHH		21.4427174698
223PhosphorylationGLIPYDQSGFVSAIR
ECCCCCCCHHHHHHH		31.1627174698
224 (in isoform 2)Ubiquitination-22.72-
227PhosphorylationYDQSGFVSAIRQVIT
CCCCHHHHHHHHHHH		18.7327174698
234PhosphorylationSAIRQVITTRKQAVG
HHHHHHHHHCCCCCC		22.9927174698
235PhosphorylationAIRQVITTRKQAVGP
HHHHHHHHCCCCCCC		25.4227174698
237UbiquitinationRQVITTRKQAVGPGG
HHHHHHCCCCCCCCC		40.2821890473
237 (in isoform 1)Ubiquitination-40.2821890473
247PhosphorylationVGPGGVNSGPVQIVN
CCCCCCCCCCEEEEC		41.9123532336
275PhosphorylationEPRPEPNSRSKRWLP
CCCCCCCCCCCCCCC		48.9623532336
277PhosphorylationRPEPNSRSKRWLPSH
CCCCCCCCCCCCCCC		26.7924719451
286PhosphorylationRWLPSHVYVNQGEIL
CCCCCCEEECCCCEE		6.56-
299 (in isoform 2)Ubiquitination-24.1921890473
301UbiquitinationRTEQWPRKLYMQLIP
CCCCCCHHHHHHHHH		39.63-
305 (in isoform 2)Ubiquitination-23.7621890473
318 (in isoform 2)Ubiquitination-4.99-
331UbiquitinationLVQFHFTKDLETLKS
EEEEEECCCHHHHHH		60.4121890473
331 (in isoform 1)Ubiquitination-60.4121890473
337UbiquitinationTKDLETLKSLCRIMD
CCCHHHHHHHHHHHH		49.1221890473
337 (in isoform 1)Ubiquitination-49.1221890473
338PhosphorylationKDLETLKSLCRIMDN
CCHHHHHHHHHHHHC		35.5024961811
368PhosphorylationIRVLMLLYSSEKKIF
HHEHHHHHCCCCEEE		13.2430177828
369PhosphorylationRVLMLLYSSEKKIFI
HEHHHHHCCCCEEEE		31.8030177828
370PhosphorylationVLMLLYSSEKKIFIG
EHHHHHCCCCEEEEE		39.6230177828
373UbiquitinationLLYSSEKKIFIGLIP
HHHCCCCEEEEEECC		38.5021890473
373 (in isoform 1)Ubiquitination-38.5021890473
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PTOV1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PTOV1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PTOV1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DEMA_HUMANDMTNphysical
16169070
PIN1_HUMANPIN1physical
16169070
SPTN1_HUMANSPTAN1physical
16169070
RACK1_HUMANGNB2L1physical
23455324
RS6_HUMANRPS6physical
23455324
FLOT1_HUMANFLOT1physical
15713644
HDAC1_HUMANHDAC1physical
27173435
XYLT2_HUMANXYLT2physical
27173435
RTCB_HUMANRTCBphysical
27173435
MTA2_HUMANMTA2physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PTOV1_HUMAN

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Related Literatures of Post-Translational Modification

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