dbPTM

ANR26_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ANR26_HUMAN
UniProt AC	Q9UPS8
Protein Name	Ankyrin repeat domain-containing protein 26
Gene Name	ANKRD26
Organism	Homo sapiens (Human).
Sequence Length	1709
Subcellular Localization
Protein Description	Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior..
Protein Sequence	MKKIFSKKGESPLGSFARRQRSSAGGGGEPGEGAYSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNRTALHLACANGHPEVVTLLVDRKCQLNVCDNENRTALMKAVQCQEEKCATILLEHGADPNLADVHGNTALHYAVYNEDISVATKLLLYDANIEAKNKDDLTPLLLAVSGKKQQMVEFLIKKKANVNAVDKLESSHQLISEYKEERIPKHSSQNSNSVDESSEDSLSRLSGKPGVDDSWPTSDDEDLNFDTKNVPKPSLAKLMTASQQSRKNLEATYGTVRTGNRTLFEDRDSDSQDEVVVESLPTTSIKVQCFSHPTYQSPDLLPKPSHKSLANPGLMKEEPTKPGIAKKENGIDIIESAPLEQTNNDNLTYVDEVHKNNRSDMMSALGLGQEEDIESPWDSESISENFPQKYVDPLAGAADGKEKNIGNEQAEDVFYIPSCMSGSRNFKMAKLEDTRNVGMPVAHMESPERYLHLKPTIEMKDSVPNKAGGMKDVQTSKAAEHDLEVASEEEQEREGSENNQPQVEEERKKHRNNEMEVSANIHDGATDDAEDDDDDDGLIQKRKSGETDHQQFPRKENKEYASGPALQMKEVKSTEKEKRTSKESVNSPVFGKASLLTGGLLQVDDDSSLSEIDEDEGRPTKKTSNEKNKVKNQIQSMDDVDDLTQSSETASEDCELPHSSYKNFMLLIEQLGMECKDSVSLLKIQDAALSCERLLELKKNHCELLTVKIKKMEDKVNVLQRELSETKEIKSQLEHQKVEWERELCSLRFSLNQEEEKRRNADTLYEKIREQLRRKEEQYRKEVEVKQQLELSLQTLEMELRTVKSNLNQVVQERNDAQRQLSREQNARMLQDGILTNHLSKQKEIEMAQKKMNSENSHSHEEEKDLSHKNSMLQEEIAMLRLEIDTIKNQNQEKEKKCFEDLKIVKEKNEDLQKTIKQNEETLTQTISQYNGRLSVLTAENAMLNSKLENEKQSKERLEAEVESYHSRLAAAIHDRDQSETSKRELELAFQRARDECSRLQDKMNFDVSNLKDNNEILSQQLFKTESKLNSLEIEFHHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKYIGKQESVEERLSQLQSENMLLRQQLDDAHNKADNKEKTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELISECNHLKERQYQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVTSRYRINLEDETQDLKKKLGQIRNQLQEAQDRHTEAVRCAEKMQDHKQKLEKDNAKLKVTVKKQMDKIEELQKNLLNANLSEDEKEQLKKLMELKQSLECNLDQEMKKNVELEREITGFKNLLKMTRKKLNEYENGEFSFHGDLKTSQFEMDIQINKLKHKIDDLTAELETAGSKCLHLDTKNQILQEELLSMKTVQKKCEKLQKNKKKLEQEVINLRSHIERNMVELGQVKQYKQEIEERARQEIAEKLKEVNLFLQAQAASQENLEQFRENNFASMKSQMELRIKDLESELSKIKTSQEDFNKTELEKYKQLYLEELKVRKSLSSKLTKTNERLAEVNTKLLVEKQQSRSLFTTLTTRPVMEPPCVGNLNNSLDLNRKLIPRENLVISTSNPRASNNSMENYLSKMQQELEKNITRELKEAAAELESGSIASPLGSTDESNLNQDLVWKASREYVQVLKKNYMI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MKKIFSKKGESPL --CCCCCCCCCCCCC	36.61	24719451
11	Phosphorylation	IFSKKGESPLGSFAR CCCCCCCCCCHHHHH	33.81	25159151
15	Phosphorylation	KGESPLGSFARRQRS CCCCCCHHHHHHHHC	24.34	21712546
22	Phosphorylation	SFARRQRSSAGGGGE HHHHHHHCCCCCCCC	19.05	30108239
23	Phosphorylation	FARRQRSSAGGGGEP HHHHHHCCCCCCCCC	32.87	69101541
35	Phosphorylation	GEPGEGAYSQPGYHV CCCCCCCCCCCCCCC	20.78	23186163
36	Phosphorylation	EPGEGAYSQPGYHVR CCCCCCCCCCCCCCC	29.39	23186163
40	Phosphorylation	GAYSQPGYHVRDRDL CCCCCCCCCCCCCCH	12.11	23186163
43	Methylation	SQPGYHVRDRDLGKI CCCCCCCCCCCHHHH	21.67	-
45	Methylation	PGYHVRDRDLGKIHK CCCCCCCCCHHHHCH	30.41	-
52	Ubiquitination	RDLGKIHKAASAGNV CCHHHHCHHHHCCCH	49.47	-
55 (in isoform 2)	Phosphorylation	-	41.38	-
79 (in isoform 2)	Methylation	-	4.87	-
82	Phosphorylation	DRDKMNRTALHLACA CHHHHHHHHHHHHHH	28.68	46164115
160 (in isoform 2)	Phosphorylation	-	20.30	-
162 (in isoform 2)	Phosphorylation	-	7.69	-
163 (in isoform 2)	Phosphorylation	-	21.77	-
200	Sumoylation	QMVEFLIKKKANVNA HHHHHHHHHCCCCCH	50.82	-
200	Sumoylation	QMVEFLIKKKANVNA HHHHHHHHHCCCCCH	50.82	-
213	Phosphorylation	NAVDKLESSHQLISE CHHHHHHHHHHHHHH	43.48	24719451
214	Phosphorylation	AVDKLESSHQLISEY HHHHHHHHHHHHHHH	13.08	28555341
221	Phosphorylation	SHQLISEYKEERIPK HHHHHHHHHHHHCCC	19.53	24719451
240	Phosphorylation	NSNSVDESSEDSLSR CCCCCCCCCHHHHHH	34.27	20363803
241	Phosphorylation	SNSVDESSEDSLSRL CCCCCCCCHHHHHHH	43.29	20363803
244	Phosphorylation	VDESSEDSLSRLSGK CCCCCHHHHHHHCCC	24.96	20363803
246	Phosphorylation	ESSEDSLSRLSGKPG CCCHHHHHHHCCCCC	34.82	23663014
249	Phosphorylation	EDSLSRLSGKPGVDD HHHHHHHCCCCCCCC	43.60	23186163
257	Phosphorylation	GKPGVDDSWPTSDDE CCCCCCCCCCCCCCC	30.41	22777824
260	Phosphorylation	GVDDSWPTSDDEDLN CCCCCCCCCCCCCCC	38.23	20363803
261	Phosphorylation	VDDSWPTSDDEDLNF CCCCCCCCCCCCCCC	38.70	25159151
270	Phosphorylation	DEDLNFDTKNVPKPS CCCCCCCCCCCCCHH	22.00	23186163
283	Phosphorylation	PSLAKLMTASQQSRK HHHHHHHCHHHHHHH	33.33	23312004
285	Phosphorylation	LAKLMTASQQSRKNL HHHHHCHHHHHHHHH	21.42	23312004
288	Phosphorylation	LMTASQQSRKNLEAT HHCHHHHHHHHHHHH	37.27	23312004
295	Phosphorylation	SRKNLEATYGTVRTG HHHHHHHHHEEECCC	17.07	21945579
296	Phosphorylation	RKNLEATYGTVRTGN HHHHHHHHEEECCCC	20.18	21945579
298	Phosphorylation	NLEATYGTVRTGNRT HHHHHHEEECCCCCE	9.08	21945579
305	Phosphorylation	TVRTGNRTLFEDRDS EECCCCCEEECCCCC	39.54	22617229
312	Phosphorylation	TLFEDRDSDSQDEVV EEECCCCCCCCCCEE	39.80	22617229
314	Phosphorylation	FEDRDSDSQDEVVVE ECCCCCCCCCCEEEE	43.41	22617229
322	Phosphorylation	QDEVVVESLPTTSIK CCCEEEEECCCCCEE	28.21	30108239
325	Phosphorylation	VVVESLPTTSIKVQC EEEEECCCCCEEEEE	38.17	28102081
326	Phosphorylation	VVESLPTTSIKVQCF EEEECCCCCEEEEEC	26.89	28102081
327	Phosphorylation	VESLPTTSIKVQCFS EEECCCCCEEEEECC	23.92	28102081
334	Phosphorylation	SIKVQCFSHPTYQSP CEEEEECCCCCCCCC	35.86	21945579
337	Phosphorylation	VQCFSHPTYQSPDLL EEECCCCCCCCCCCC	28.86	21945579
338	Phosphorylation	QCFSHPTYQSPDLLP EECCCCCCCCCCCCC	16.08	21945579
340	Phosphorylation	FSHPTYQSPDLLPKP CCCCCCCCCCCCCCC	15.23	21945579
351	Phosphorylation	LPKPSHKSLANPGLM CCCCCCCCCCCCCCC	27.56	22210691
363	Phosphorylation	GLMKEEPTKPGIAKK CCCCCCCCCCCCCCC	53.82	22210691
461	Phosphorylation	EDVFYIPSCMSGSRN CCEEECCCCCCCCCC	16.94	24719451
464	Phosphorylation	FYIPSCMSGSRNFKM EECCCCCCCCCCCCE	37.63	28348404
466	Phosphorylation	IPSCMSGSRNFKMAK CCCCCCCCCCCCEEE	19.42	27251275
489	Phosphorylation	MPVAHMESPERYLHL CCCCCCCCHHHCCCC	25.20	30266825
493	Phosphorylation	HMESPERYLHLKPTI CCCCHHHCCCCCCEE	9.23	29978859
503	Ubiquitination	LKPTIEMKDSVPNKA CCCEEECCCCCCCCC	33.78	-
518	Phosphorylation	GGMKDVQTSKAAEHD CCCCCCCHHHHHHHH	31.85	29083192
519	Phosphorylation	GMKDVQTSKAAEHDL CCCCCCHHHHHHHHH	11.82	29083192
530	Phosphorylation	EHDLEVASEEEQERE HHHHHHCCHHHHHHH	51.20	29255136
539	Phosphorylation	EEQEREGSENNQPQV HHHHHHCCCCCCHHH	32.19	30108239
561	Phosphorylation	RNNEMEVSANIHDGA HCCCCCEEEEECCCC	11.42	26471730
569	Phosphorylation	ANIHDGATDDAEDDD EEECCCCCCCCCCCC	39.68	26471730
587	Phosphorylation	GLIQKRKSGETDHQQ CCCCCCCCCCCCCCC	45.99	30266825
590	Phosphorylation	QKRKSGETDHQQFPR CCCCCCCCCCCCCCC	42.16	30266825
603 (in isoform 3)	Phosphorylation	-	14.00	-
605 (in isoform 3)	Phosphorylation	-	44.39	-
606 (in isoform 3)	Phosphorylation	-	11.88	-
624	Phosphorylation	TEKEKRTSKESVNSP CHHHHCCCCCCCCCC	38.16	24961811
627	Phosphorylation	EKRTSKESVNSPVFG HHCCCCCCCCCCCCC	30.27	30266825
630	Phosphorylation	TSKESVNSPVFGKAS CCCCCCCCCCCCCHH	21.93	10470851
631	Phosphorylation	SKESVNSPVFGKASL CCCCCCCCCCCCHHH	21.91	19413330
637	Phosphorylation	SPVFGKASLLTGGLL CCCCCCHHHHHCCCE	27.65	30177828
640	Phosphorylation	FGKASLLTGGLLQVD CCCHHHHHCCCEEEC	34.20	30177828
650	Phosphorylation	LLQVDDDSSLSEIDE CEEECCCCCCCCCCC	39.92	26471730
651	Phosphorylation	LQVDDDSSLSEIDED EEECCCCCCCCCCCC	42.80	26471730
652	Phosphorylation	QVDDDSSLSEIDEDE EECCCCCCCCCCCCC	6.53	18452278
653	Phosphorylation	VDDDSSLSEIDEDEG ECCCCCCCCCCCCCC	34.16	26471730
654	Phosphorylation	DDDSSLSEIDEDEGR CCCCCCCCCCCCCCC	60.80	18452278
663	Phosphorylation	DEDEGRPTKKTSNEK CCCCCCCCCCCCHHH	43.76	30177828
666	Phosphorylation	EGRPTKKTSNEKNKV CCCCCCCCCHHHHHH	38.04	25954137
667	Phosphorylation	GRPTKKTSNEKNKVK CCCCCCCCHHHHHHH	52.45	25954137
721	Phosphorylation	LGMECKDSVSLLKIQ HCCCCCCCHHHHHHH	10.09	68729465
723	Phosphorylation	MECKDSVSLLKIQDA CCCCCCHHHHHHHHH	31.75	68729471
767	Phosphorylation	NVLQRELSETKEIKS HHHHHHHHHHHHHHH	38.17	29396449
769	Phosphorylation	LQRELSETKEIKSQL HHHHHHHHHHHHHHH	30.51	29396449
774	Phosphorylation	SETKEIKSQLEHQKV HHHHHHHHHHHHCHH	45.73	24719451
775	Phosphorylation	ETKEIKSQLEHQKVE HHHHHHHHHHHCHHH	45.96	-
879	Phosphorylation	MLQDGILTNHLSKQK HHHHHHHHHHHHHHH	20.76	28258704
883	Phosphorylation	GILTNHLSKQKEIEM HHHHHHHHHHHHHHH	26.03	28258704
900	Phosphorylation	KKMNSENSHSHEEEK HHHCCCCCCCHHHHH	23.47	28985074
902	Phosphorylation	MNSENSHSHEEEKDL HCCCCCCCHHHHHHH	32.20	50565489
929	Phosphorylation	MLRLEIDTIKNQNQE HHHHHHHHHHCCCHH	39.24	23403867
940	Acetylation	QNQEKEKKCFEDLKI CCHHHHHHHHHHHHH	45.29	18530787
949	Acetylation	FEDLKIVKEKNEDLQ HHHHHHHHHHCHHHH	67.46	18530797
951	Ubiquitination	DLKIVKEKNEDLQKT HHHHHHHHCHHHHHH	60.98	-
957	Ubiquitination	EKNEDLQKTIKQNEE HHCHHHHHHHHHCHH	60.56	-
958	Phosphorylation	KNEDLQKTIKQNEET HCHHHHHHHHHCHHH	22.05	29052541
978	Phosphorylation	SQYNGRLSVLTAENA HHHCCCEEEHHHHHH	17.45	9874017
997	Phosphorylation	KLENEKQSKERLEAE HHCCHHHHHHHHHHH	47.77	50565481
1068	Ubiquitination	LSQQLFKTESKLNSL HHHHHHHHHHHHHCE	37.85	-
1124	Phosphorylation	EQVKVNKYIGKQESV HHHHHHHHCCCHHHH	15.09	29449344
1130	Phosphorylation	KYIGKQESVEERLSQ HHCCCHHHHHHHHHH	32.13	30624053
1131	Phosphorylation	YIGKQESVEERLSQL HCCCHHHHHHHHHHH	9.72	-
1136	Phosphorylation	ESVEERLSQLQSENM HHHHHHHHHHHHHHH	34.76	-
1181	Phosphorylation	VQKLQAESEKQSLLL HHHHHHHHHHHHHHH	53.78	22210691
1184	Ubiquitination	LQAESEKQSLLLEER HHHHHHHHHHHHHHH	34.95	-
1204	Ubiquitination	SECNHLKERQYQYEN HHHHHHHHHHHHHHC	51.91	-
1235	Phosphorylation	ADTLKKQSMSEASLE HHHHHHCCCCHHHHH	32.91	30206219
1237	Phosphorylation	TLKKQSMSEASLEVT HHHHCCCCHHHHHHH	34.95	30206219
1240	Phosphorylation	KQSMSEASLEVTSRY HCCCCHHHHHHHHHE	22.47	30206219
1244	Phosphorylation	SEASLEVTSRYRINL CHHHHHHHHHEECCC	9.71	30206219
1245	Phosphorylation	EASLEVTSRYRINLE HHHHHHHHHEECCCC	32.27	30206219
1290	Acetylation	AEKMQDHKQKLEKDN HHHHHHHHHHHHHHC	58.37	7429723
1316	Acetylation	DKIEELQKNLLNANL HHHHHHHHHHHCCCC	63.29	19413330
1317	Acetylation	KIEELQKNLLNANLS HHHHHHHHHHCCCCC	36.48	19413330
1317	Ubiquitination	KIEELQKNLLNANLS HHHHHHHHHHCCCCC	36.48	19413330
1324	Phosphorylation	NLLNANLSEDEKEQL HHHCCCCCHHHHHHH	42.69	72551405
1325	Phosphorylation	LLNANLSEDEKEQLK HHCCCCCHHHHHHHH	73.65	19413330
1329	Ubiquitination	NLSEDEKEQLKKLME CCCHHHHHHHHHHHH	60.13	-
1332	Acetylation	EDEKEQLKKLMELKQ HHHHHHHHHHHHHHH	43.48	18586065
1333	Acetylation	DEKEQLKKLMELKQS HHHHHHHHHHHHHHH	62.75	18586075
1338	Acetylation	LKKLMELKQSLECNL HHHHHHHHHHHHCCC	25.24	7934205
1340	Phosphorylation	KLMELKQSLECNLDQ HHHHHHHHHHCCCCH	25.25	28258704
1390	Phosphorylation	FHGDLKTSQFEMDIQ ECCCCCCCCEEEHHH	31.14	17525332
1391	Phosphorylation	HGDLKTSQFEMDIQI CCCCCCCCEEEHHHH	43.48	17525332
1426	Ubiquitination	CLHLDTKNQILQEEL CCCCCCCCHHHHHHH	35.90	-
1435	Phosphorylation	ILQEELLSMKTVQKK HHHHHHHCCHHHHHH	30.75	20068231
1436	Phosphorylation	LQEELLSMKTVQKKC HHHHHHCCHHHHHHH	4.21	20068231
1453	Ubiquitination	LQKNKKKLEQEVINL HHHHHHHHHHHHHHH	12.95	-
1493	Ubiquitination	RQEIAEKLKEVNLFL HHHHHHHHHHHHHHH	4.27	-
1522	Methylation	ENNFASMKSQMELRI HCCHHHHHHHHHHHH	34.73	23644510
1531	Ubiquitination	QMELRIKDLESELSK HHHHHHHHHHHHHHH	53.98	-
1539	Ubiquitination	LESELSKIKTSQEDF HHHHHHHHCCCHHHH	5.45	-
1541	Ubiquitination	SELSKIKTSQEDFNK HHHHHHCCCHHHHCH	38.83	-
1549	Ubiquitination	SQEDFNKTELEKYKQ CHHHHCHHHHHHHHH	47.08	-
1556	Ubiquitination	TELEKYKQLYLEELK HHHHHHHHHHHHHHH	32.05	-
1569	Phosphorylation	LKVRKSLSSKLTKTN HHHHHHHHHHCCHHH	32.30	25262027
1570	Phosphorylation	KVRKSLSSKLTKTNE HHHHHHHHHCCHHHH	36.66	25262027
1573	Phosphorylation	KSLSSKLTKTNERLA HHHHHHCCHHHHHHH	39.29	25262027
1591	Ubiquitination	TKLLVEKQQSRSLFT HHHHHHHHHHHCCCE	32.73	-
1640	Phosphorylation	STSNPRASNNSMENY ECCCCCCCCCHHHHH	37.51	26471730
1643	Phosphorylation	NPRASNNSMENYLSK CCCCCCCHHHHHHHH	31.55	26471730
1647	Phosphorylation	SNNSMENYLSKMQQE CCCHHHHHHHHHHHH	10.07	26471730
1651	Ubiquitination	MENYLSKMQQELEKN HHHHHHHHHHHHHHH	4.46	-
1660	Phosphorylation	QELEKNITRELKEAA HHHHHHHHHHHHHHH	27.73	21955146
1661	Phosphorylation	ELEKNITRELKEAAA HHHHHHHHHHHHHHH	43.37	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ANR26_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ANR26_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ANR26_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ANR26_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ANR26_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-489, AND MASSSPECTROMETRY.	19690332 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1390, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-283, AND MASSSPECTROMETRY.	17081983 [Abstract]