LMBL4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LMBL4_HUMAN
• UniProt AC: Q8NA19
• Protein Name: Lethal(3)malignant brain tumor-like protein 4
• Gene Name: L3MBTL4
• Organism: Homo sapiens (Human).
• Sequence Length: 623
• Subcellular Localization: Nucleus .
• Protein Description: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity)..
• Protein Sequence: MKQPNRKRKLNMDSKERLDQDGRLEQAEEEKKPKDSTTPLSHVPSAAAQGAWSWEWYLKEQKAVAAPVELFSKDQSFPEHENGFQIGMRLEGIDPRHPSVFCVLSVAEVCGYRLRLHFDGYLSCYDFWTNAGSPDIHPVGWCEKTKHELHIPKGYRKDKFVWMDYLKACKLQNAPKKLFRNRSPNGPMSKEFQVGMKLEAVDRKNPSLVCVATIADIVEDRLLVHFDNWDDSYDYWCDVNSPYVQPVGWCQENGRTLIAPQGYPNPENFSWTEYLEATQTNAVPAKVFKMRLPHGFLPNMKLEVVDKRNPRLIRVATIVDVDDQRVKVHFDGWDHKYDYWVEADSPDIHPIGWCDVTGHPLEVPQRTNDLKILPGQAVCPTPGCRGIGHIRGPRYSGHHSAFGCPYSDMNLKKEATLHDRLREQTQANLESDSSHSKSKSLCSLNFNGKHEKVNSQPRLVQQAKCLKIKGKEDIDLDNLFRVLVLHPRGLEYSVEQAQQVLHQSVSMSTVSAHPFRDLPLGREQHCKLLPGVADIRASQVARWTVDEVAEFVQSLLGCEEHAKCFKKEQIDGKAFLLLTQTDIVKVMKIKLGPALKIYNSILMFRHSQELPEEDIASGQEVRG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	EKKPKDSTTPLSHVP HCCCCCCCCCCCCCC	42.43	-
38	Phosphorylation	KKPKDSTTPLSHVPS CCCCCCCCCCCCCCC	26.61	-
45	Phosphorylation	TPLSHVPSAAAQGAW CCCCCCCCHHHCCCC	29.47	-
72	Phosphorylation	AAPVELFSKDQSFPE CCCHHHHCCCCCCCC	48.20	24719451
165	Phosphorylation	DKFVWMDYLKACKLQ CCEEHHHHHHHHHCC	8.26	-
301	Sumoylation	HGFLPNMKLEVVDKR CCCCCCCEEEEECCC	48.40	-
301	Sumoylation	HGFLPNMKLEVVDKR CCCCCCCEEEEECCC	48.40	-
395	Phosphorylation	GHIRGPRYSGHHSAF CCCCCCCCCCCCCCC	23.34	-
431	Phosphorylation	QTQANLESDSSHSKS HHHHHHHCCCCCCCC	46.06	25954137
433	Phosphorylation	QANLESDSSHSKSKS HHHHHCCCCCCCCCC	38.95	25954137
434	Phosphorylation	ANLESDSSHSKSKSL HHHHCCCCCCCCCCC	36.45	25954137
436	Phosphorylation	LESDSSHSKSKSLCS HHCCCCCCCCCCCEE	40.34	25954137
440	Phosphorylation	SSHSKSKSLCSLNFN CCCCCCCCCEEEECC	41.52	-
443	Phosphorylation	SKSKSLCSLNFNGKH CCCCCCEEEECCCCC	31.47	-
509 (in isoform 2)	Phosphorylation	-	15.16	22210691
520 (in isoform 2)	Phosphorylation	-	15.24	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LMBL4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LMBL4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LMBL4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.