CLC1B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLC1B_HUMAN
• UniProt AC: Q9P126
• Protein Name: C-type lectin domain family 1 member B
• Gene Name: CLEC1B
• Organism: Homo sapiens (Human).
• Sequence Length: 229
• Subcellular Localization: Membrane ; Single-pass type II membrane protein .
• Protein Description: C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN. [PubMed: 18215137 After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2]
• Protein Sequence: MQDEDGYITLNIKTRKPALISVGSASSSWWRVMALILLILCVGMVVGLVALGIWSVMQRNYLQGENENRTGTLQQLAKRFCQYVVKQSELKGTFKGHKCSPCDTNWRYYGDSCYGFFRHNLTWEESKQYCTDMNATLLKIDNRNIVEYIKARTHLIRWVGLSRQKSNEVWKWEDGSVISENMFEFLEDGKGNMNCAYFHNGKMHPTFCENKHYLMCERKAGMTKVDQLP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MQDEDGYITLNIKT -CCCCCCEEEEEEEE	11.76	10671229
9	Phosphorylation	QDEDGYITLNIKTRK CCCCCEEEEEEEECC	12.79	30619164
68	N-linked_Glycosylation	YLQGENENRTGTLQQ CCCCCCCCCCCHHHH	59.40	UniProtKB CARBOHYD
120	N-linked_Glycosylation	CYGFFRHNLTWEESK CCHHHHCCCCHHHHH	34.60	UniProtKB CARBOHYD
122	Phosphorylation	GFFRHNLTWEESKQY HHHHCCCCHHHHHHH	35.83	-
126	Phosphorylation	HNLTWEESKQYCTDM CCCCHHHHHHHHCCC	17.34	-
129	Phosphorylation	TWEESKQYCTDMNAT CHHHHHHHHCCCCCE	10.89	24043423
131	Phosphorylation	EESKQYCTDMNATLL HHHHHHHCCCCCEEE	33.09	24043423
134	N-linked_Glycosylation	KQYCTDMNATLLKID HHHHCCCCCEEEEEC	32.36	UniProtKB CARBOHYD
136	Phosphorylation	YCTDMNATLLKIDNR HHCCCCCEEEEECCC	27.85	24043423
223	Phosphorylation	CERKAGMTKVDQLP- EEECCCCCCCCCCC-	27.31	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RACK1	P63244	PMID:19785988

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLC1B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLC1B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHIP_HUMAN	STUB1	physical	27443248

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.