ADA12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ADA12_HUMAN
• UniProt AC: O43184
• Protein Name: Disintegrin and metalloproteinase domain-containing protein 12
• Gene Name: ADAM12
• Organism: Homo sapiens (Human).
• Sequence Length: 909
• Subcellular Localization: Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.; Isoform 3: Secreted .; Isoform 4: Secreted .
• Protein Description: Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity)..
• Protein Sequence: MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFDSKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVTILCLLAAGFVVYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPPDSYPPKDNPRRLLQCQNVDISRPLNGLNVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKPALRQAQGTCKPNPPQKPLPADPLARTTRLTHALARTPGQWETGLRLAPLRPAPQYPHQVPRSTHTAYIK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
111	N-linked_Glycosylation	TDVSLARNYTVILGH CCCCHHHCEEEEEEE	31.08	UniProtKB CARBOHYD
149	N-linked_Glycosylation	RGLIVFENESYVLEP CEEEEECCCCEEECC	31.86	UniProtKB CARBOHYD
381	N-linked_Glycosylation	EKGGCIMNASTGYPF ECCCEEEECCCCCCC	15.72	UniProtKB CARBOHYD
430	Methylation	GGQKCGNRFVEEGEE CCCCCCCCCCCCCCC	23.44	-
449	Dimethylation	EPEECMNRCCNATTC CHHHHHHHHCCCCCC	10.24	-
449	Methylation	EPEECMNRCCNATTC CHHHHHHHHCCCCCC	10.24	-
452	N-linked_Glycosylation	ECMNRCCNATTCTLK HHHHHHCCCCCCCCC	43.90	UniProtKB CARBOHYD
651	N-linked_Glycosylation	CLNRQCQNISVFGVH EECCCCCCEEEECHH	35.81	UniProtKB CARBOHYD
782	Phosphorylation	LMRKPPDSYPPKDNP CCCCCCCCCCCCCCC	45.36	62162251
783	Phosphorylation	MRKPPDSYPPKDNPR CCCCCCCCCCCCCCC	30.82	29632367
876	Phosphorylation	LTHALARTPGQWETG HHHHHHCCCCCCCCC	26.60	25954137
882	Phosphorylation	RTPGQWETGLRLAPL CCCCCCCCCCEECCC	38.26	45553629
895	Phosphorylation	PLRPAPQYPHQVPRS CCCCCCCCCCCCCCC	11.13	25884760
902	Phosphorylation	YPHQVPRSTHTAYIK CCCCCCCCCCCEECC	20.62	25954137
903	Phosphorylation	PHQVPRSTHTAYIK- CCCCCCCCCCEECC-	25.24	25954137
907	Phosphorylation	PRSTHTAYIK----- CCCCCCEECC-----	15.48	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
907	Y	Phosphorylation	Kinase	SRC	P12931	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ADA12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ADA12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IBP5_HUMAN	IGFBP5	physical	11095942
IBP3_HUMAN	IGFBP3	physical	11095942
P85A_HUMAN	PIK3R1	physical	11313349

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.