ES8L1_HUMAN - dbPTM
ES8L1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ES8L1_HUMAN
UniProt AC Q8TE68
Protein Name Epidermal growth factor receptor kinase substrate 8-like protein 1
Gene Name EPS8L1
Organism Homo sapiens (Human).
Sequence Length 723
Subcellular Localization Cytoplasm .
Protein Description Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton..
Protein Sequence MSTATGPEAAPKPSAKSIYEQRKRYSTVVMADVSQYPVNHLVTFCLGEDDGVHTVEDASRKLAVMDSQGRVWAQEMLLRVSPDHVTLLDPASKEELESYPLGAIVRCDAVMPPGRSRSLLLLVCQEPERAQPDVHFFQGLRLGAELIREDIQGALHNYRSGRGERRAAALRATQEELQRDRSPAAETPPLQRRPSVRAVISTVERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASPDLGPRGPDLAVLQAEREVDILNHVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGEGLLTLRAKPPSEAEYTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSGGPEFASSVRRPHLTSDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPEEGPPYRPEFFSGWEPPVTDPQSRAWEDPVEKQLQHERRRRQQSAPQVAVNGHRDLEPESEPQLESETAGKWVLCNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYNILTPYPGPRLHHSQSPARSLNSTPPPPPAPAPAPPPALARPRWDRPRWDSCDSLNGLDPSEKEKFSQMLIVNEELQARLAQGRSGPSRAVPGPRAPEPQLSPGSDASEVRAWLQAKGFSSGTVDALGVLTGAQLFSLQKEELRAVSPEEGARVYSQVTVQRSLLEDKEKVSELEAVMEKQKKKVEGEVEMEVI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSTATGPEA
------CCCCCCCCC		27.0924719451
3Phosphorylation-----MSTATGPEAA
-----CCCCCCCCCC		27.2627251275
5 (in isoform 4)Phosphorylation-54.0528634120
8 (in isoform 4)Phosphorylation-59.8328634120
17PhosphorylationAPKPSAKSIYEQRKR
CCCCCHHHHHHHHHC		30.0728102081
19PhosphorylationKPSAKSIYEQRKRYS
CCCHHHHHHHHHCCC		17.0728102081
26PhosphorylationYEQRKRYSTVVMADV
HHHHHCCCEEEEEEH		20.8228348404
27PhosphorylationEQRKRYSTVVMADVS
HHHHCCCEEEEEEHH		14.2628348404
55 (in isoform 2)Phosphorylation-3.65-
60PhosphorylationHTVEDASRKLAVMDS
EEHHHHHHHEEEECC		39.4633259812
60 (in isoform 2)Phosphorylation-39.46-
61UbiquitinationTVEDASRKLAVMDSQ
EHHHHHHHEEEECCC		38.0029967540
116PhosphorylationAVMPPGRSRSLLLLV
EECCCCCCCEEEEEE		31.9424670416
118PhosphorylationMPPGRSRSLLLLVCQ
CCCCCCCEEEEEEEC		25.3123312004
164 (in isoform 3)Phosphorylation-37.32-
169 (in isoform 3)Phosphorylation-9.15-
173PhosphorylationRAAALRATQEELQRD
HHHHHHHHHHHHHHC		30.0422617229
182PhosphorylationEELQRDRSPAAETPP
HHHHHCCCCCCCCCC		24.1529255136
187PhosphorylationDRSPAAETPPLQRRP
CCCCCCCCCCCCCCC		26.0219664994
195PhosphorylationPPLQRRPSVRAVIST
CCCCCCCCHHHHHHH		23.5624719451
201PhosphorylationPSVRAVISTVERGAG
CCHHHHHHHHHCCCC		21.5728355574
201 (in isoform 2)Phosphorylation-21.57-
202PhosphorylationSVRAVISTVERGAGR
CHHHHHHHHHCCCCC		18.4327422710
231PhosphorylationQRPEPVGTSSNADSA
CCCCCCCCCCCCCCC		29.2628102081
232PhosphorylationRPEPVGTSSNADSAS
CCCCCCCCCCCCCCC		18.7025841592
233PhosphorylationPEPVGTSSNADSASP
CCCCCCCCCCCCCCC		35.5628102081
237PhosphorylationGTSSNADSASPDLGP
CCCCCCCCCCCCCCC		28.3825841592
239PhosphorylationSSNADSASPDLGPRG
CCCCCCCCCCCCCCC		23.9325849741
305PhosphorylationAAGEGLLTLRAKPPS
HHCCCCEEEECCCCC		21.1728857561
310 (in isoform 3)Phosphorylation-36.34-
316PhosphorylationKPPSEAEYTDVLQKI
CCCCHHHHHHHHHHH		18.4527732954
317PhosphorylationPPSEAEYTDVLQKIK
CCCHHHHHHHHHHHH		15.9027732954
325PhosphorylationDVLQKIKYAFSLLAR
HHHHHHHHHHHHHHH		19.1520068231
328PhosphorylationQKIKYAFSLLARLRG
HHHHHHHHHHHHHCC		17.8220068231
342PhosphorylationGNIADPSSPELLHFL
CCCCCCCCHHHHHHH		27.9922210691
359PhosphorylationPLQMIVNTSGGPEFA
CCEEEEECCCCHHHH		20.1822210691
454PhosphorylationERRRRQQSAPQVAVN
HHHHHHHCCCCHHHC		33.3128348404
494PhosphorylationYDFQARNSSELSVKQ
CEECCCCCCCCCCCH		21.4528348404
495PhosphorylationDFQARNSSELSVKQR
EECCCCCCCCCCCHH		46.2124114839
526PhosphorylationDPAGQEGYVPYNILT
CCCCCCCCCCCEEEE		9.4828152594
529PhosphorylationGQEGYVPYNILTPYP
CCCCCCCCEEEECCC		12.5628152594
533PhosphorylationYVPYNILTPYPGPRL
CCCCEEEECCCCCCC		19.5822617229
535PhosphorylationPYNILTPYPGPRLHH
CCEEEECCCCCCCCC		18.6528152594
543PhosphorylationPGPRLHHSQSPARSL
CCCCCCCCCCCCHHC		22.9326657352
545PhosphorylationPRLHHSQSPARSLNS
CCCCCCCCCCHHCCC		24.4425849741
549PhosphorylationHSQSPARSLNSTPPP
CCCCCCHHCCCCCCC		33.7330242111
552PhosphorylationSPARSLNSTPPPPPA
CCCHHCCCCCCCCCC		47.8130183078
553PhosphorylationPARSLNSTPPPPPAP
CCHHCCCCCCCCCCC		38.4528355574
580PhosphorylationWDRPRWDSCDSLNGL
CCCCCCCCCCHHCCC		16.9223927012
583PhosphorylationPRWDSCDSLNGLDPS
CCCCCCCHHCCCCHH		28.2323927012
590PhosphorylationSLNGLDPSEKEKFSQ
HHCCCCHHHHHHHHH		62.0528102081
617PhosphorylationAQGRSGPSRAVPGPR
HCCCCCCCCCCCCCC		36.0820363803
631PhosphorylationRAPEPQLSPGSDASE
CCCCCCCCCCCCHHH		23.2030278072
634PhosphorylationEPQLSPGSDASEVRA
CCCCCCCCCHHHHHH		33.1330278072
637PhosphorylationLSPGSDASEVRAWLQ
CCCCCCHHHHHHHHH		41.4327251275
649PhosphorylationWLQAKGFSSGTVDAL
HHHHCCCCCCCCHHH		36.2027251275
650PhosphorylationLQAKGFSSGTVDALG
HHHCCCCCCCCHHHH		35.9027251275
652PhosphorylationAKGFSSGTVDALGVL
HCCCCCCCCHHHHHH		19.7027251275
660PhosphorylationVDALGVLTGAQLFSL
CHHHHHHHHHHHHHC		28.23-
676PhosphorylationKEELRAVSPEEGARV
HHHHHCCCHHHCCHH		26.1327050516
684PhosphorylationPEEGARVYSQVTVQR
HHHCCHHEEEHHHHH		6.4528152594
685PhosphorylationEEGARVYSQVTVQRS
HHCCHHEEEHHHHHH		18.4728152594
688PhosphorylationARVYSQVTVQRSLLE
CHHEEEHHHHHHHHC		11.8623879269
701PhosphorylationLEDKEKVSELEAVME
HCCHHHHHHHHHHHH		47.7523879269
709AcetylationELEAVMEKQKKKVEG
HHHHHHHHHHHHHCC		49.6924884203
712AcetylationAVMEKQKKKVEGEVE
HHHHHHHHHHCCCCE		60.6024884213
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ES8L1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ES8L1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ES8L1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ABI1_HUMANABI1physical
14565974
SOS1_HUMANSOS1physical
14565974
ACTG_HUMANACTG1physical
14565974
DPP8_HUMANDPP8physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ES8L1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-182 AND THR-187, ANDMASS SPECTROMETRY.

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