IF1AY_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IF1AY_HUMAN
• UniProt AC: O14602
• Protein Name: Eukaryotic translation initiation factor 1A, Y-chromosomal
• Gene Name: EIF1AY
• Organism: Homo sapiens (Human).
• Sequence Length: 144
• Protein Description: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity)..
• Protein Sequence: MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEALCFDGVKRLCHIRGKLRKKVWINTSDIILVGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQFDDIGDDDEDIDDI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Acetylation	-----MPKNKGKGGK -----CCCCCCCCCC	70.73	18435499
5	Acetylation	---MPKNKGKGGKNR ---CCCCCCCCCCCC	69.03	18435509
7	Acetylation	-MPKNKGKGGKNRRR -CCCCCCCCCCCCCC	67.13	18435519
23	Ubiquitination	KNENESEKRELVFKE CCCCHHHHHEEEEEC	61.52	-
29	Ubiquitination	EKRELVFKEDGQEYA HHHEEEEECCHHHHH	47.63	-
29	Acetylation	EKRELVFKEDGQEYA HHHEEEEECCHHHHH	47.63	26051181
29	2-Hydroxyisobutyrylation	EKRELVFKEDGQEYA HHHEEEEECCHHHHH	47.63	-
35	Phosphorylation	FKEDGQEYAQVIKML EECCHHHHHHHHHHH	8.41	27642862
40	Ubiquitination	QEYAQVIKMLGNGRL HHHHHHHHHHCCCCE	29.26	21906983
56	Ubiquitination	ALCFDGVKRLCHIRG EEEEHHHHHHHHHHH	45.22	-
56	Acetylation	ALCFDGVKRLCHIRG EEEEHHHHHHHHHHH	45.22	23749302
67	Ubiquitination	HIRGKLRKKVWINTS HHHHHHCCCEEEECC	63.21	-
68	Ubiquitination	IRGKLRKKVWINTSD HHHHHCCCEEEECCC	36.05	-
73	Phosphorylation	RKKVWINTSDIILVG CCCEEEECCCEEEEE	20.74	21815630
74	Phosphorylation	KKVWINTSDIILVGL CCEEEECCCEEEEEC	23.48	21815630
82	Methylation	DIILVGLRDYQDNKA CEEEEECCCCCCCCC	34.36	-
84	Phosphorylation	ILVGLRDYQDNKADV EEEECCCCCCCCCCE	16.01	28152594
88	Malonylation	LRDYQDNKADVILKY CCCCCCCCCCEEEEE	55.01	26320211
88	Ubiquitination	LRDYQDNKADVILKY CCCCCCCCCCEEEEE	55.01	-
88	Acetylation	LRDYQDNKADVILKY CCCCCCCCCCEEEEE	55.01	23954790
94	Sumoylation	NKADVILKYNADEAR CCCCEEEEECHHHHH	25.90	-
94	Acetylation	NKADVILKYNADEAR CCCCEEEEECHHHHH	25.90	26051181
94	Ubiquitination	NKADVILKYNADEAR CCCCEEEEECHHHHH	25.90	21890473
94	2-Hydroxyisobutyrylation	NKADVILKYNADEAR CCCCEEEEECHHHHH	25.90	-
95	Phosphorylation	KADVILKYNADEARS CCCEEEEECHHHHHH	16.49	-
102	Phosphorylation	YNADEARSLKAYGEL ECHHHHHHHHHHCCC	41.07	25849741
104	Acetylation	ADEARSLKAYGELPE HHHHHHHHHHCCCCC	40.59	25953088
104	Malonylation	ADEARSLKAYGELPE HHHHHHHHHHCCCCC	40.59	26320211
104	2-Hydroxyisobutyrylation	ADEARSLKAYGELPE HHHHHHHHHHCCCCC	40.59	-
104	Ubiquitination	ADEARSLKAYGELPE HHHHHHHHHHCCCCC	40.59	2190698
106	Phosphorylation	EARSLKAYGELPEHA HHHHHHHHCCCCCCC	15.00	28152594

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IF1AY_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IF1AY_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IF1AY_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IF1AX_HUMAN	EIF1AX	physical	28514442
KLH36_HUMAN	KLHL36	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Ubiquitylation

"Quantitative analysis of global ubiquitination in HeLa cells by massspectrometry.";
Meierhofer D., Wang X., Huang L., Kaiser P.;
J. Proteome Res. 7:4566-4576(2008).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-88, AND MASSSPECTROMETRY.
PubMed: 18781797