DOCK3_HUMAN - dbPTM
DOCK3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DOCK3_HUMAN
UniProt AC Q8IZD9
Protein Name Dedicator of cytokinesis protein 3
Gene Name DOCK3
Organism Homo sapiens (Human).
Sequence Length 2030
Subcellular Localization Cytoplasm.
Protein Description Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors (By similarity)..
Protein Sequence MWTPTEEEKYGVVICSFRGSVPQGLVLEIGETVQILEKCEGWYRGVSTKKPNVKGIFPANYIHLKKAIVSNRGQYETVVPLEDSIVTEVTATLQEWASLWKQLYVKHKVDLFYKLRHVMNELIDLRRQLLSGHLTQDQVREVKRHITVRLDWGNEHLGLDLVPRKDFEVVDSDQISVSDLYKMHLSSRQSVQQSTSQVDTMRPRHGETCRMPVPHHFFLSLKSFTYNTIGEDTDVFFSLYDMREGKQISERFLVRLNKNGGPRNPEKIERMCALFTDLSSKDMKRDLYIVAHVIRIGRMLLNDSKKGPPHLHYRRPYGCAVLSILDVLQSLTEVKEEKDFVLKVYTCNNESEWSQIHENIIRKSSAKYSAPSASHGLIISLQLLRGDMEQIRRENPMIFNRGLAITRKLGFPDVIMPGDIRNDLYLTLEKGDFERGGKSVQKNIEVTMYVLYADGEILKDCISLGSGEPNRSSYHSFVLYHSNSPRWGEIIKLPIPIDRFRGSHLRFEFRHCSTKDKGEKKLFGFAFSTLMRDDGTTLSDDIHELYVYKCDENSTFNNHALYLGLPCCKEDYNGCPNIPSSLIFQRSTKESFFISTQLSSTKLTQNVDLLALLKWKAFPDRIMDVLGRLRHVSGEEIVKFLQDILDTLFVILDDNTEKYGLLVFQSLVFIINLLRDIKYFHFRPVMDTYIQKHFAGALAYKELIRCLKWYMDCSAELIRQDHIQEAMRALEYLFKFIVQSRILYSRATCGMEEEQFRSSIQELFQSIRFVLSLDSRNSETLLFTQAALLNSFPTIFDELLQMFTVQEVAEFVRGTLGSMPSTVHIGQSMDVVKLQSIARTVDSRLFSFSESRRILLPVVLHHIHLHLRQQKELLICSGILGSIFSIVKTSSLEADVMEEVEMMVESLLDVLLQTLLTIMSKSHAQEAVRGQRCPQCTAEITGEYVSCLLSLLRQMCDTHFQHLLDNFQSKDELKEFLLKIFCVFRNLMKMSVFPRDWMVMRLLTSNIIVTTVQYLSSALHKNFTETDFDFKVWNSYFSLAVLFINQPSLQLEIITSAKRKKILDKYGDMRVMMAYELFSMWQNLGEHKIHFIPGMIGPFLGVTLVPQPEVRNIMIPIFHDMMDWEQRKNGNFKQVEAELIDKLDSMVSEGKGDESYRELFSLLTQLFGPYPSLLEKVEQETWRETGISFVTSVTRLMERLLDYRDCMKGEETENKKIGCTVNLMNFYKSEINKEEMYIRYIHKLCDMHLQAENYTEAAFTLLLYCELLQWEDRPLREFLHYPSQTEWQRKEGLCRKIIHYFNKGKSWEFGIPLCRELACQYESLYDYQSLSWIRKMEASYYDNIMEQQRLEPEFFRVGFYGRKFPFFLRNKEYVCRGHDYERLEAFQQRMLSEFPQAVAMQHPNHPDDAILQCDAQYLQIYAVTPIPDYVDVLQMDRVPDRVKSFYRVNNVRKFRYDRPFHKGPKDKENEFKSLWIERTTLTLTHSLPGISRWFEVERRELVEVSPLENAIQVVENKNQELRSLISQYQHKQVHGNINLLSMCLNGVIDAAVNGGIARYQEAFFDKDYINKHPGDAEKITQLKELMQEQVHVLGVGLAVHEKFVHPEMRPLHKKLIDQFQMMRASLYHEFPGLDKLSPACSGTSTPRGNVLASHSPMSPESIKMTHRHSPMNLMGTGRHSSSSLSSHASSEAGNMVMLGDGSMGDAPEDLYHHMQLAYPNPRYQGSVTNVSVLSSSQASPSSSSLSSTHSAPSQMITSAPSSARGSPSLPDKYRHAREMMLLLPTYRDRPSSAMYPAAILENGQPPNFQRALFQQVVGACKPCSDPNLSVAEKGHYSLHFDAFHHPLGDTPPALPARTLRKSPLHPIPASPTSPQSGLDGSNSTLSGSASSGVSSLSESNFGHSSEAPPRTDTMDSMPSQAWNADEDLEPPYLPVHYSLSESAVLDSIKAQPCRSHSAPGCVIPQDPMDPPALPPKPYHPRLPALEHDEGVLLREETERPRGLHRKAPLPPGSAKEEQARMAWEHGRGEQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MWTPTEEEKY
-----CCCCCHHHHC		31.9930622161
5Phosphorylation---MWTPTEEEKYGV
---CCCCCHHHHCCE		48.9630622161
172PhosphorylationKDFEVVDSDQISVSD
CCCEEECCCCCCHHH		21.5829759185
176PhosphorylationVVDSDQISVSDLYKM
EECCCCCCHHHHHHH		15.2229759185
186PhosphorylationDLYKMHLSSRQSVQQ
HHHHHHHHCCHHHHH		14.5929978859
187PhosphorylationLYKMHLSSRQSVQQS
HHHHHHHCCHHHHHH		40.4729978859
190PhosphorylationMHLSSRQSVQQSTSQ
HHHHCCHHHHHHCCC		22.3029978859
194PhosphorylationSRQSVQQSTSQVDTM
CCHHHHHHCCCCCCC		16.9729978859
195PhosphorylationRQSVQQSTSQVDTMR
CHHHHHHCCCCCCCC		20.8829978859
196PhosphorylationQSVQQSTSQVDTMRP
HHHHHHCCCCCCCCC		33.1929978859
200PhosphorylationQSTSQVDTMRPRHGE
HHCCCCCCCCCCCCC		19.0729978859
304PhosphorylationGRMLLNDSKKGPPHL
HHHHHCCCCCCCCCC		34.88-
372PhosphorylationSAKYSAPSASHGLII
CCCCCCCCHHHHHHH		41.96-
408UbiquitinationRGLAITRKLGFPDVI
CHHHHHHHHCCCCEE		44.2930230243
537PhosphorylationLMRDDGTTLSDDIHE
HHCCCCCCCCCCCEE		29.78-
548PhosphorylationDIHELYVYKCDENST
CCEEEEEEECCCCCC		7.73-
604PhosphorylationQLSSTKLTQNVDLLA
CCCCCCCCCCCCHHH		21.4724670416
679PhosphorylationNLLRDIKYFHFRPVM
HHHCCCCCCCCCCCH		11.56-
689PhosphorylationFRPVMDTYIQKHFAG
CCCCHHHHHHHHHHH		9.33-
700PhosphorylationHFAGALAYKELIRCL
HHHHHHHHHHHHHHH		13.07-
745PhosphorylationVQSRILYSRATCGME
HHHHHHHHCCCCCCC		16.4024719451
766PhosphorylationSIQELFQSIRFVLSL
HHHHHHHHHHHHHCC		14.3824719451
815PhosphorylationVAEFVRGTLGSMPST
HHHHHHHCCCCCCCE		19.85-
821PhosphorylationGTLGSMPSTVHIGQS
HCCCCCCCEEEECCC		34.13-
836PhosphorylationMDVVKLQSIARTVDS
CCEEHHHHHHHHHCH		28.7524719451
889PhosphorylationSIFSIVKTSSLEADV
HHHHHHHCCCCCCHH		16.8023403867
890PhosphorylationIFSIVKTSSLEADVM
HHHHHHCCCCCCHHH		27.4923403867
891PhosphorylationFSIVKTSSLEADVME
HHHHHCCCCCCHHHH		35.1523403867
906PhosphorylationEVEMMVESLLDVLLQ
HHHHHHHHHHHHHHH		23.8726074081
914PhosphorylationLLDVLLQTLLTIMSK
HHHHHHHHHHHHHCH		24.5723403867
917PhosphorylationVLLQTLLTIMSKSHA
HHHHHHHHHHCHHHH		20.1123403867
920PhosphorylationQTLLTIMSKSHAQEA
HHHHHHHCHHHHHHH		27.4423403867
1026PhosphorylationLHKNFTETDFDFKVW
HHHCCCCCCCCHHHH		38.62-
1145PhosphorylationELIDKLDSMVSEGKG
HHHHHHHHHHHCCCC		31.3629759185
1148PhosphorylationDKLDSMVSEGKGDES
HHHHHHHHCCCCCHH		31.8029759185
1172PhosphorylationQLFGPYPSLLEKVEQ
HHHCCCHHHHHHHHH		39.4824719451
1181PhosphorylationLEKVEQETWRETGIS
HHHHHHHHHHHHCHH		29.5322210691
1185PhosphorylationEQETWRETGISFVTS
HHHHHHHHCHHHHHH		31.1022210691
1194PhosphorylationISFVTSVTRLMERLL
HHHHHHHHHHHHHHH		20.1824719451
1203PhosphorylationLMERLLDYRDCMKGE
HHHHHHCHHHHHCCC		14.3424719451
1517UbiquitinationAIQVVENKNQELRSL
HHHHHHCCCHHHHHH		46.6430230243
1559PhosphorylationVNGGIARYQEAFFDK
HHCCHHHHHHHHCCH		11.1519835603
1568PhosphorylationEAFFDKDYINKHPGD
HHHCCHHHHHCCCCC		16.4819835603
1625PhosphorylationQFQMMRASLYHEFPG
HHHHHHHHHHHHCCC		21.0629083192
1627PhosphorylationQMMRASLYHEFPGLD
HHHHHHHHHHCCCCC		9.2329083192
1658PhosphorylationLASHSPMSPESIKMT
EECCCCCCHHHHHCC		28.9724076635
1661PhosphorylationHSPMSPESIKMTHRH
CCCCCHHHHHCCCCC		30.7825307156
1669PhosphorylationIKMTHRHSPMNLMGT
HHCCCCCCCCCCCCC		26.2927050516
1748PhosphorylationSSSSLSSTHSAPSQM
CCCCCCCCCCCCCHH		19.2425332170
1757PhosphorylationSAPSQMITSAPSSAR
CCCCHHCCCCCCCCC		17.3125332170
1761PhosphorylationQMITSAPSSARGSPS
HHCCCCCCCCCCCCC		36.0219651622
1762PhosphorylationMITSAPSSARGSPSL
HCCCCCCCCCCCCCC		22.4119651622
1785PhosphorylationEMMLLLPTYRDRPSS
HHHHHCCCCCCCCCC		31.0328348404
1786PhosphorylationMMLLLPTYRDRPSSA
HHHHCCCCCCCCCCC		14.4728348404
1791PhosphorylationPTYRDRPSSAMYPAA
CCCCCCCCCCCCCHH		31.4628348404
1792PhosphorylationTYRDRPSSAMYPAAI
CCCCCCCCCCCCHHH		21.5328348404
1795PhosphorylationDRPSSAMYPAAILEN
CCCCCCCCCHHHHHC		6.8828348404
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DOCK3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DOCK3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DOCK3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of DOCK3_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DOCK3_HUMAN

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Related Literatures of Post-Translational Modification

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