dbPTM

PPBT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PPBT_HUMAN
UniProt AC	P05186
Protein Name	Alkaline phosphatase, tissue-nonspecific isozyme
Gene Name	ALPL
Organism	Homo sapiens (Human).
Sequence Length	524
Subcellular Localization	Cell membrane Lipid-anchor, GPI-anchor .
Protein Description	This isozyme may play a role in skeletal mineralization..
Protein Sequence	MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4 (in isoform 2)	Phosphorylation	-	18.70	-
48	Phosphorylation	LELQKLNTNVAKNVI HHHHHCCCHHHHHHH	41.32	46162759
100	Phosphorylation	PFVALSKTYNTNAQV CEEEEECEECCCCCC	20.73	23663014
101	Phosphorylation	FVALSKTYNTNAQVP EEEEECEECCCCCCC	24.59	23663014
103	Phosphorylation	ALSKTYNTNAQVPDS EEECEECCCCCCCCC	22.86	23663014
110	Phosphorylation	TNAQVPDSAGTATAY CCCCCCCCCCCCEEE	23.64	25463755
113	Phosphorylation	QVPDSAGTATAYLCG CCCCCCCCCEEEEEE	22.13	25463755
115	Phosphorylation	PDSAGTATAYLCGVK CCCCCCCEEEEEEEE	18.70	23663014
117	Phosphorylation	SAGTATAYLCGVKAN CCCCCEEEEEEEECC	9.73	23663014
131	Phosphorylation	NEGTVGVSAATERSR CCCCCCEEEECCHHH	13.27	21712546
140	N-linked_Glycosylation	ATERSRCNTTQGNEV ECCHHHCCCCCCCHH	45.08	UniProtKB CARBOHYD
149	Phosphorylation	TQGNEVTSILRWAKD CCCCHHHHHHHHHHH	25.46	24719451
160	Phosphorylation	WAKDAGKSVGIVTTT HHHHCCCEEEEEEEC	25.34	46162753
230	N-linked_Glycosylation	RKYMYPKNKTDVEYE CCCCCCCCCCCCCCC	48.21	UniProtKB CARBOHYD
232	O-linked_Glycosylation	YMYPKNKTDVEYESD CCCCCCCCCCCCCCC	55.46	30059200
236	Phosphorylation	KNKTDVEYESDEKAR CCCCCCCCCCCHHHC	22.15	26657352
271	N-linked_Glycosylation	KHSHFIWNRTELLTL CCCCEEECCCEEEEC	35.86	UniProtKB CARBOHYD
303	N-linked_Glycosylation	QYELNRNNVTDPSLS CEEHHCCCCCCCHHH	34.52	UniProtKB CARBOHYD
308	Phosphorylation	RNNVTDPSLSEMVVV CCCCCCCHHHHHHHH	47.54	28387310
310	Phosphorylation	NVTDPSLSEMVVVAI CCCCCHHHHHHHHHH	28.16	28387310
394	Phosphorylation	GYTPRGNSIFGLAPM CCCCCCCCCCCCCCC	23.32	28555341
415	Phosphorylation	KPFTAILYGNGPGYK CCEEEEECCCCCCCE	11.48	25367160
430	N-linked_Glycosylation	VVGGERENVSMVDYA EECCCCCEEEEEECC	37.07	19159218
501	GPI-anchor	LGHCAPASSAGSLAA CCCCCCCCHHHHHHH	21.47	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PPBT_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PPBT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PPBT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EF1A1_HUMAN	EEF1A1	physical	16014383
LOX5_HUMAN	ALOX5	physical	26210919
SPCS2_HUMAN	SPCS2	physical	28514442
SC11C_HUMAN	SEC11C	physical	28514442

Drug and Disease Associations

Kegg Disease
H00213	Hypophosphatasia
OMIM Disease
146300	Hypophosphatasia (HOPS)
241510	Hypophosphatasia childhood type (HOPSC)
241500	Hypophosphatasia infantile type (HOPSI)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PPBT_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-430, AND MASSSPECTROMETRY.	19159218 [Abstract]