SC11C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SC11C_HUMAN
• UniProt AC: Q9BY50
• Protein Name: Signal peptidase complex catalytic subunit SEC11C
• Gene Name: SEC11C
• Organism: Homo sapiens (Human).
• Sequence Length: 192
• Subcellular Localization: Microsome membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein.
• Protein Description: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum..
• Protein Sequence: MVRAGAVGAHLPASGLDIFGDLKKMNKRQLYYQVLNFAMIVSSALMIWKGLIVLTGSESPIVVVLSGSMEPAFHRGDLLFLTNFREDPIRAGEIVVFKVEGRDIPIVHRVIKVHEKDNGDIKFLTKGDNNEVDDRGLYKEGQNWLEKKDVVGRARGFLPYVGMVTIIMNDYPKFKYALLAVMGAYVLLKRES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Ubiquitination	LDIFGDLKKMNKRQL CCCCCCHHHCCHHHH	55.50	21906983
24	Ubiquitination	DIFGDLKKMNKRQLY CCCCCHHHCCHHHHH	55.81	-
31	Phosphorylation	KMNKRQLYYQVLNFA HCCHHHHHHHHHHHH	5.41	25884760
32	Phosphorylation	MNKRQLYYQVLNFAM CCHHHHHHHHHHHHH	10.75	25884760
68	Phosphorylation	IVVVLSGSMEPAFHR EEEEEECCCCCCCCC	19.32	20068231
82	Phosphorylation	RGDLLFLTNFREDPI CCCEEEEECCCCCCC	25.61	20068231
98	Ubiquitination	AGEIVVFKVEGRDIP CCCEEEEEEECCCCC	27.97	21890473
112	Ubiquitination	PIVHRVIKVHEKDNG CEEEEEEEEEECCCC	34.38	-
116	Ubiquitination	RVIKVHEKDNGDIKF EEEEEEECCCCCEEE	41.43	-
122	Ubiquitination	EKDNGDIKFLTKGDN ECCCCCEEEEECCCC	38.78	21890473
126	Ubiquitination	GDIKFLTKGDNNEVD CCEEEEECCCCCCCC	67.43	21906983
139	Ubiquitination	VDDRGLYKEGQNWLE CCCCHHHHHCCCHHH	61.48	21890473
147	Ubiquitination	EGQNWLEKKDVVGRA HCCCHHHHCHHHHHH	52.70	21890473
148	Ubiquitination	GQNWLEKKDVVGRAR CCCHHHHCHHHHHHC	46.51	-
160	Phosphorylation	RARGFLPYVGMVTII HHCCCCCEEEEEEEE	16.28	-
171	Phosphorylation	VTIIMNDYPKFKYAL EEEECCCCHHHHHHH	11.88	-
176	Phosphorylation	NDYPKFKYALLAVMG CCCHHHHHHHHHHHH	12.96	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SC11C_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SC11C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SC11C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPCS2_HUMAN	SPCS2	physical	28514442
FUND2_HUMAN	FUNDC2	physical	28514442
APOM_HUMAN	APOM	physical	28514442
SPCS3_HUMAN	SPCS3	physical	28514442
SPCS1_HUMAN	SPCS1	physical	28514442
GGT7_HUMAN	GGT7	physical	28514442
CC50A_HUMAN	TMEM30A	physical	28514442
GHDC_HUMAN	GHDC	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.