NSG1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NSG1_HUMAN
• UniProt AC: P42857
• Protein Name: Neuronal vesicle trafficking-associated protein 1 {ECO:0000305}
• Gene Name: NSG1 {ECO:0000312|HGNC:HGNC:18790}
• Organism: Homo sapiens (Human).
• Sequence Length: 185
• Subcellular Localization: Membrane ; Single-pass type II membrane protein . Golgi apparatus, trans-Golgi network membrane . Endosome membrane . Cell projection, dendrite . Early endosome membrane . Late endosome membrane . Lysosome lumen . Recycling endosome membrane . Cytoplasmic
• Protein Description: Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (By similarity). In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage. [PubMed: 20599942]
• Protein Sequence: MVKLGNNFAEKGTKQPLLEDGFDTIPLMTPLDVNQLQFPPPDKVVVKTKTEYEPDRKKGKARPPQIAEFTVSITEGVTERFKVSVLVLFALAFLTCVVFLVVYKVYKYDRACPDGFVLKNTQCIPEGLESYYAEQDSSAREKFYTVINHYNLAKQSITRSVSPWMSVLSEEKLSEQETEAAEKSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Ubiquitination	LGNNFAEKGTKQPLL CCCCCCCCCCCCCCC	69.33	-
11	Ubiquitination	LGNNFAEKGTKQPLL CCCCCCCCCCCCCCC	69.33	-
14	Ubiquitination	NFAEKGTKQPLLEDG CCCCCCCCCCCCCCC	59.60	-
14	Ubiquitination	NFAEKGTKQPLLEDG CCCCCCCCCCCCCCC	59.60	-
52	Phosphorylation	VVKTKTEYEPDRKKG EEEECCCCCCCCCCC	37.68	25884760
145	O-linked_Glycosylation	SAREKFYTVINHYNL CHHHHHHHHHCHHHH	20.31	55826495
150	Phosphorylation	FYTVINHYNLAKQSI HHHHHCHHHHHHHHH	13.84	30301811
166	O-linked_Glycosylation	RSVSPWMSVLSEEKL HCCCHHHHHHCHHHH	18.95	OGP
174	Phosphorylation	VLSEEKLSEQETEAA HHCHHHHCHHHHHHH	48.58	-
178	Phosphorylation	EKLSEQETEAAEKSA HHHCHHHHHHHHHHC	30.53	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NSG1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NSG1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NSG1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KASH5_HUMAN	CCDC155	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.