RHG12_HUMAN - dbPTM
RHG12_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RHG12_HUMAN
UniProt AC Q8IWW6
Protein Name Rho GTPase-activating protein 12
Gene Name ARHGAP12
Organism Homo sapiens (Human).
Sequence Length 846
Subcellular Localization
Protein Description GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state..
Protein Sequence MKMADRSGKIIPGQVYIEVEYDYEYEAKDRKIVIKQGERYILVKKTNDDWWQVKPDENSKAFYVPAQYVKEVTRKALMPPVKQVAGLPNNSTKIMQSLHLQRSTENVNKLPELSSFGKPSSSVQGTGLIRDANQNFGPSYNQGQTVNLSLDLTHNNGKFNNDSHSPKVSSQNRTRSFGHFPGPEFLDVEKTSFSQEQSCDSAGEGSERIHQDSESGDELSSSSTEQIRATTPPNQGRPDSPVYANLQELKISQSALPPLPGSPAIQINGEWETHKDSSGRCYYYNRGTQERTWKPPRWTRDASISKGDFQNPGDQELLSSEENYYSTSYSQSDSQCGSPPRGWSEELDERGHTLYTSDYTNEKWLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSLDRRLQEPIVLTKWRHSTIVLDTNDKESPTASKPCFPENESSPSSPKHQDTASSPKDQEKYGLLNVTKIAENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGATIEMASKDKSSKKNVFELKTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEEEIPDSPGIEKHDKEKEQKDPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKDLIRQLPKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQIVELILLELSSIFGR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
40PhosphorylationVIKQGERYILVKKTN
EEECCCEEEEEEECC		8.3623917254
46PhosphorylationRYILVKKTNDDWWQV
EEEEEEECCCCCEEC		37.8626074081
59PhosphorylationQVKPDENSKAFYVPA
ECCCCCCCCEEEEEH		24.2626074081
63PhosphorylationDENSKAFYVPAQYVK
CCCCCEEEEEHHHHH		15.4728152594
68PhosphorylationAFYVPAQYVKEVTRK
EEEEEHHHHHHHHHH		18.6528152594
91PhosphorylationVAGLPNNSTKIMQSL
HCCCCCCHHHHHHHH		37.4030576142
92PhosphorylationAGLPNNSTKIMQSLH
CCCCCCHHHHHHHHH		27.0630576142
97PhosphorylationNSTKIMQSLHLQRST
CHHHHHHHHHHHHCC		10.6129514088
103PhosphorylationQSLHLQRSTENVNKL
HHHHHHHCCCCHHHC		27.4130266825
104PhosphorylationSLHLQRSTENVNKLP
HHHHHHCCCCHHHCC		33.4930266825
114PhosphorylationVNKLPELSSFGKPSS
HHHCCHHHHCCCCCC		23.2028152594
115PhosphorylationNKLPELSSFGKPSSS
HHCCHHHHCCCCCCC		51.1228464451
120PhosphorylationLSSFGKPSSSVQGTG
HHHCCCCCCCCCCCC		38.4423927012
121PhosphorylationSSFGKPSSSVQGTGL
HHCCCCCCCCCCCCE		42.9523927012
122PhosphorylationSFGKPSSSVQGTGLI
HCCCCCCCCCCCCEE		23.8523927012
126PhosphorylationPSSSVQGTGLIRDAN
CCCCCCCCCEECCCC		16.2423927012
163PhosphorylationNGKFNNDSHSPKVSS
CCCCCCCCCCCCCCC		28.1729255136
165PhosphorylationKFNNDSHSPKVSSQN
CCCCCCCCCCCCCCC		30.3029255136
174PhosphorylationKVSSQNRTRSFGHFP
CCCCCCCCCCCCCCC		37.9125159151
176PhosphorylationSSQNRTRSFGHFPGP
CCCCCCCCCCCCCCH		34.6629255136
191PhosphorylationEFLDVEKTSFSQEQS
HHCCCCCCCCCCCCC		22.8425159151
192PhosphorylationFLDVEKTSFSQEQSC
HCCCCCCCCCCCCCC		33.6925159151
194PhosphorylationDVEKTSFSQEQSCDS
CCCCCCCCCCCCCCC		32.3525159151
198PhosphorylationTSFSQEQSCDSAGEG
CCCCCCCCCCCCCCC		21.0923927012
201PhosphorylationSQEQSCDSAGEGSER
CCCCCCCCCCCCCCC		42.3623927012
206PhosphorylationCDSAGEGSERIHQDS
CCCCCCCCCCCCCCC		21.2823927012
213PhosphorylationSERIHQDSESGDELS
CCCCCCCCCCCCCCC		27.3925159151
215PhosphorylationRIHQDSESGDELSSS
CCCCCCCCCCCCCCC		56.3429255136
220PhosphorylationSESGDELSSSSTEQI
CCCCCCCCCCCCCHH		26.5723927012
221PhosphorylationESGDELSSSSTEQIR
CCCCCCCCCCCCHHH		40.7225849741
222PhosphorylationSGDELSSSSTEQIRA
CCCCCCCCCCCHHHC		37.5923927012
223PhosphorylationGDELSSSSTEQIRAT
CCCCCCCCCCHHHCC		37.6023927012
224PhosphorylationDELSSSSTEQIRATT
CCCCCCCCCHHHCCC		33.5823403867
230PhosphorylationSTEQIRATTPPNQGR
CCCHHHCCCCCCCCC		29.9529255136
231PhosphorylationTEQIRATTPPNQGRP
CCHHHCCCCCCCCCC		35.4529255136
240PhosphorylationPNQGRPDSPVYANLQ
CCCCCCCCCCCCHHH		20.9629255136
243PhosphorylationGRPDSPVYANLQELK
CCCCCCCCCHHHHCE		7.9922167270
254PhosphorylationQELKISQSALPPLPG
HHCEECHHCCCCCCC		25.6128102081
262PhosphorylationALPPLPGSPAIQING
CCCCCCCCCCEEECC		14.8225159151
273PhosphorylationQINGEWETHKDSSGR
EECCEEEEEECCCCC		34.9925002506
303PhosphorylationPRWTRDASISKGDFQ
CCCCCCCCCCCCCCC		31.5127251275
303 (in isoform 3)Phosphorylation-31.5130266825
305 (in isoform 3)Phosphorylation-28.2630266825
306UbiquitinationTRDASISKGDFQNPG
CCCCCCCCCCCCCCC		61.9121906983
306 (in isoform 3)Ubiquitination-61.9121906983
327PhosphorylationSEENYYSTSYSQSDS
CCCCCCCCCCCCCCC		18.6330576142
330PhosphorylationNYYSTSYSQSDSQCG
CCCCCCCCCCCCCCC		23.9926657352
332PhosphorylationYSTSYSQSDSQCGSP
CCCCCCCCCCCCCCC		33.0330576142
334PhosphorylationTSYSQSDSQCGSPPR
CCCCCCCCCCCCCCC		32.3928348404
338PhosphorylationQSDSQCGSPPRGWSE
CCCCCCCCCCCCCCH		39.0828348404
353PhosphorylationELDERGHTLYTSDYT
HHHHCCCEEECCCCC		25.0428796482
355PhosphorylationDERGHTLYTSDYTNE
HHCCCEEECCCCCCC		12.8328796482
356PhosphorylationERGHTLYTSDYTNEK
HCCCEEECCCCCCCC		20.4528796482
357PhosphorylationRGHTLYTSDYTNEKW
CCCEEECCCCCCCCH		18.3128796482
359PhosphorylationHTLYTSDYTNEKWLK
CEEECCCCCCCCHHC		15.9528796482
360PhosphorylationTLYTSDYTNEKWLKH
EEECCCCCCCCHHCC		41.7228796482
366MethylationYTNEKWLKHVDDQGR
CCCCCHHCCCCCCCC		40.23-
375PhosphorylationVDDQGRQYYYSADGS
CCCCCCEEEECCCCC		11.7423917254
376PhosphorylationDDQGRQYYYSADGSR
CCCCCEEEECCCCCC		5.2122817900
377PhosphorylationDQGRQYYYSADGSRS
CCCCEEEECCCCCCC		7.7622817900
391PhosphorylationSEWELPKYNASSQQQ
CCCCCCCCCCCHHHH		17.6420068231
394PhosphorylationELPKYNASSQQQREI
CCCCCCCCHHHHHHH		25.6620068231
395PhosphorylationLPKYNASSQQQREII
CCCCCCCHHHHHHHH		29.6020068231
400 (in isoform 3)Phosphorylation-44.7329116813
401 (in isoform 3)Phosphorylation-5.3929116813
403 (in isoform 3)Phosphorylation-45.5425159151
404PhosphorylationQQREIIKSRSLDRRL
HHHHHHHHHHHHHHH		19.3820068231
404 (in isoform 3)Phosphorylation-19.3825849741
406PhosphorylationREIIKSRSLDRRLQE
HHHHHHHHHHHHHCC		41.5326699800
423PhosphorylationVLTKWRHSTIVLDTN
EEEECCCCEEEEECC		15.9729255136
423 (in isoform 2)Phosphorylation-15.9725850435
424PhosphorylationLTKWRHSTIVLDTND
EEECCCCEEEEECCC		14.6929255136
424 (in isoform 2)Phosphorylation-14.6925850435
429PhosphorylationHSTIVLDTNDKESPT
CCEEEEECCCCCCCC		40.9527050516
432"N6,N6-dimethyllysine"IVLDTNDKESPTASK
EEEECCCCCCCCCCC		63.26-
432MethylationIVLDTNDKESPTASK
EEEECCCCCCCCCCC		63.26-
434PhosphorylationLDTNDKESPTASKPC
EECCCCCCCCCCCCC		33.0425849741
436PhosphorylationTNDKESPTASKPCFP
CCCCCCCCCCCCCCC		53.4923663014
438PhosphorylationDKESPTASKPCFPEN
CCCCCCCCCCCCCCC		39.3423663014
447PhosphorylationPCFPENESSPSSPKH
CCCCCCCCCCCCCCC		60.1623663014
447 (in isoform 4)Phosphorylation-60.1629116813
448PhosphorylationCFPENESSPSSPKHQ
CCCCCCCCCCCCCCC		23.7123663014
448 (in isoform 4)Phosphorylation-23.7129116813
450PhosphorylationPENESSPSSPKHQDT
CCCCCCCCCCCCCCC		62.3123663014
450 (in isoform 4)Phosphorylation-62.3125159151
451PhosphorylationENESSPSSPKHQDTA
CCCCCCCCCCCCCCC		41.1523663014
451 (in isoform 4)Phosphorylation-41.1525849741
457PhosphorylationSSPKHQDTASSPKDQ
CCCCCCCCCCCHHHH		23.1328348404
459PhosphorylationPKHQDTASSPKDQEK
CCCCCCCCCHHHHHH		49.6328348404
460PhosphorylationKHQDTASSPKDQEKY
CCCCCCCCHHHHHHH		33.2428348404
467PhosphorylationSPKDQEKYGLLNVTK
CHHHHHHHCCEEHHH		16.5627642862
513PhosphorylationSSTSWFGSNQSKPEF
CCCCCCCCCCCCCEE		23.4028857561
521PhosphorylationNQSKPEFTVDLKGAT
CCCCCEEEEECCCCE		16.0821082442
528PhosphorylationTVDLKGATIEMASKD
EEECCCCEEEECCCC		26.5821406692
531SulfoxidationLKGATIEMASKDKSS
CCCCEEEECCCCCCC		4.5130846556
533PhosphorylationGATIEMASKDKSSKK
CCEEEECCCCCCCCC		39.8221406692
571PhosphorylationNDWFKVLSSTINNQA
HHHHHHHHHHHCCEE		28.5523927012
572PhosphorylationDWFKVLSSTINNQAV
HHHHHHHHHHCCEEE		29.1923927012
573PhosphorylationWFKVLSSTINNQAVE
HHHHHHHHHCCEEEE		25.0923927012
581PhosphorylationINNQAVETDEGIEEE
HCCEEEECCCCHHHH		32.5230266825
592PhosphorylationIEEEIPDSPGIEKHD
HHHHCCCCCCCCCCC		21.4830266825
600UbiquitinationPGIEKHDKEKEQKDP
CCCCCCCHHHHHCCH		71.10-
602UbiquitinationIEKHDKEKEQKDPKK
CCCCCHHHHHCCHHH		71.79-
612PhosphorylationKDPKKLRSFKVSSID
CCHHHHHCCEECCCC		39.6027422710
614MethylationPKKLRSFKVSSIDSS
HHHHHCCEECCCCCH		42.31-
616PhosphorylationKLRSFKVSSIDSSEQ
HHHCCEECCCCCHHH		23.3629255136
617PhosphorylationLRSFKVSSIDSSEQK
HHCCEECCCCCHHHH		33.1426657352
620PhosphorylationFKVSSIDSSEQKKTK
CEECCCCCHHHHHHH		33.8229255136
621PhosphorylationKVSSIDSSEQKKTKK
EECCCCCHHHHHHHH		40.0628857561
639PhosphorylationKFLTRRPTLQAVREK
HHHHHCHHHHHHHHH		29.6830266825
691PhosphorylationGLDIDGIYRVSGNLA
CCCCCCEEEEECCEE		15.53-
694PhosphorylationIDGIYRVSGNLAVIQ
CCCEEEEECCEEHHH		16.99-
796AcetylationRVIENGEKNRMTYQS
HHHHCCCCCCCEEEE		51.7822368431
796UbiquitinationRVIENGEKNRMTYQS
HHHHCCCCCCCEEEE		51.78-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RHG12_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RHG12_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RHG12_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MUC5B_HUMANMUC5Bphysical
28514442
BPIB1_HUMANBPIFB1physical
28514442
DMBT1_HUMANDMBT1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RHG12_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213; SER-215; SER-240AND TYR-243, AND MASS SPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-201; THR-231 ANDSER-240, AND MASS SPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-201; SER-213; SER-215;THR-230; SER-240 AND SER-592, AND MASS SPECTROMETRY.
"Robust phosphoproteomic profiling of tyrosine phosphorylation sitesfrom human T cells using immobilized metal affinity chromatography andtandem mass spectrometry.";
Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M.,Peters E.C.;
Anal. Chem. 76:2763-2772(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-231; SER-240 ANDTYR-243, AND MASS SPECTROMETRY.

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