ATS18_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATS18_HUMAN
• UniProt AC: Q8TE60
• Protein Name: A disintegrin and metalloproteinase with thrombospondin motifs 18
• Gene Name: ADAMTS18
• Organism: Homo sapiens (Human).
• Sequence Length: 1221
• Subcellular Localization: Secreted, extracellular space, extracellular matrix.
• Protein Sequence: MECALLLACAFPAAGSGPPRGLAGLGRVAKALQLCCLCCASVAAALASDSSSGASGLNDDYVFVTPVEVDSAGSYISHDILHNGRKKRSAQNARSSLHYRFSAFGQELHLELKPSAILSSHFIVQVLGKDGASETQKPEVQQCFYQGFIRNDSSSSVAVSTCAGLSGLIRTRKNEFLISPLPQLLAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHASQSRETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKREDPSCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTRKI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
99	Phosphorylation	NARSSLHYRFSAFGQ HHHHHHHHHHHHCCC	20.74	7314713
151	N-linked_Glycosylation	FYQGFIRNDSSSSVA HHHCCCCCCCCCCCH	49.01	UniProtKB CARBOHYD
190	N-linked_Glycosylation	QLLAQEHNYSSPAGH HHHHHHCCCCCCCCC	37.31	UniProtKB CARBOHYD
224	Phosphorylation	YPGSGRNYPGYSPSH CCCCCCCCCCCCHHH	9.18	25907765
227	Phosphorylation	SGRNYPGYSPSHIPH CCCCCCCCCHHHCCC	16.95	25907765
228	Phosphorylation	GRNYPGYSPSHIPHA CCCCCCCCHHHCCCC	26.33	25907765
230	Phosphorylation	NYPGYSPSHIPHASQ CCCCCCHHHCCCCCC	28.27	25907765
236	Phosphorylation	PSHIPHASQSRETEY HHHCCCCCCCCCCHH	26.17	25907765
238	Phosphorylation	HIPHASQSRETEYHH HCCCCCCCCCCHHHH	29.59	25907765
285	Phosphorylation	SSGRPRRSAGKSQKG CCCCCCCCCCCCCCC	42.53	22468782
297	Phosphorylation	QKGLNVETLVVADKK CCCCCCEEEEEECHH	22.14	22468782
311	Acetylation	KMVEKHGKGNVTTYI HHHHHHCCCCHHHHH	47.21	19829053
313	N-linked_Glycosylation	VEKHGKGNVTTYILT HHHHCCCCHHHHHHH	31.29	UniProtKB CARBOHYD
330	Acetylation	NMVSGLFKDGTIGSD HHHHHHCCCCCCCCC	61.36	19829061
462	Phosphorylation	KAEGNIMSPTLTGNN CCCCCEECCEECCCC	15.78	46159265
475	Phosphorylation	NNGVFSWSSCSRQYL CCCCCCCHHHCHHHH	21.92	22210691
475	O-linked_Glycosylation	NNGVFSWSSCSRQYL CCCCCCCHHHCHHHH	21.92	29351928
506	Phosphorylation	KQAGQYKYPDKLPGQ CCCCCCCCCCCCCCC	16.24	25907765
515	Phosphorylation	DKLPGQIYDADTQCK CCCCCCEECCCCCCC	9.37	25907765
519	Phosphorylation	GQIYDADTQCKWQFG CCEECCCCCCCEECC	37.27	25907765
647	Phosphorylation	INPCNENSLDFRAQQ CCCCCCCCCCHHHHH	24.12	24719451
660	Phosphorylation	QQCAEYNSKPFRGWF HHHHHHCCCCCCCCC	40.58	26074081
668	Phosphorylation	KPFRGWFYQWKPYTK CCCCCCCCCCCCCCC	13.62	26074081
745	N-linked_Glycosylation	CGVCKGDNSTCKFYK CCCCCCCCCCCCEEC	48.14	UniProtKB CARBOHYD
755	Phosphorylation	CKFYKGLYLNQHKAN CCEECCEEECCCCCC	16.57	7344043
764	Phosphorylation	NQHKANEYYPVVLIP CCCCCCCCCCEEEEE	16.93	7344053
765	Phosphorylation	QHKANEYYPVVLIPA CCCCCCCCCEEEEEC	5.38	7344063
788	Phosphorylation	ELQVSSSYLAVRSLS EEEECCCHHHHEECC	10.71	31136913
793	Phosphorylation	SSYLAVRSLSQKYYL CCHHHHEECCCCEEE	26.27	46159271
795	Phosphorylation	YLAVRSLSQKYYLTG HHHHEECCCCEEECC	26.35	46159277
838	N-linked_Glycosylation	LYAPGPTNETLVFEI EECCCCCCCEEHHHH	43.31	UniProtKB CARBOHYD
883	Phosphorylation	YTWSIVQSECSVSCG EEEEEEEEEEEEEEC	29.67	46159283
886	Phosphorylation	SIVQSECSVSCGGGY EEEEEEEEEEECCCE	17.02	29083192
888	Phosphorylation	VQSECSVSCGGGYIN EEEEEEEEECCCEEE	7.25	29083192
893	Phosphorylation	SVSCGGGYINVKAIC EEEECCCEEEEEEEE	7.81	46159289
909	N-linked_Glycosylation	RDQNTQVNSSFCSAK CCCCCCCCCCCCCCC	23.32	UniProtKB CARBOHYD
941	Phosphorylation	YWMPGEWSTCSKACA EECCCCHHHCCHHCC	18.42	19690332
1060	Phosphorylation	RLQWVASSWSECSAT CCHHHHCCHHHHHHH	25.53	46159259
1100	Sumoylation	ERRCRNIKKPNLDLE HHHCCCCCCCCCCHH	66.77	-
1101	Sumoylation	RRCRNIKKPNLDLEE HHCCCCCCCCCCHHH	35.03	-
1109	Phosphorylation	PNLDLEETCNRRACP CCCCHHHHHCCCCCC	13.00	22817900
1209	Phosphorylation	GVCNHKFYGKQCCKS CCCCCCCCCHHHHHH	28.37	20562747

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATS18_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATS18_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATS18_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
B3GLT_HUMAN	B3GALTL	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442
ALBU_HUMAN	ALB	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.