KCNN2_HUMAN - dbPTM
KCNN2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KCNN2_HUMAN
UniProt AC Q9H2S1
Protein Name Small conductance calcium-activated potassium channel protein 2
Gene Name KCNN2
Organism Homo sapiens (Human).
Sequence Length 579
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin..
Protein Sequence MSSCRYNGGVMRPLSNLSASRRNLHEMDSEAQPLQPPASVGGGGGASSPSAAAAAAAAVSSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIEAQMESYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSSCRYNGG
------CCCCCCCCC		37.8429449344
3Phosphorylation-----MSSCRYNGGV
-----CCCCCCCCCC		11.0029449344
6Phosphorylation--MSSCRYNGGVMRP
--CCCCCCCCCCCCC		23.6129449344
7Phosphorylation-MSSCRYNGGVMRPL
-CCCCCCCCCCCCCH		22.7624719451
15PhosphorylationGGVMRPLSNLSASRR
CCCCCCHHHHCHHHC		38.1129449344
18PhosphorylationMRPLSNLSASRRNLH
CCCHHHHCHHHCCHH		28.5727732954
20PhosphorylationPLSNLSASRRNLHEM
CHHHHCHHHCCHHHC		28.5324719451
53 (in isoform 2)Ubiquitination-9.4320972266
90PhosphorylationGTGGGGSTGGGGGGG
ECCCCCCCCCCCCCC		43.0218452278
119PhosphorylationKKNQNIGYKLGHRRA
CCCCCCCHHHHHHHH		10.1522461510
135PhosphorylationFEKRKRLSDYALIFG
HHHHHHHHHHHHHHH		32.3826074081
137PhosphorylationKRKRLSDYALIFGMF
HHHHHHHHHHHHHHH		10.4226074081
160PhosphorylationTELSWGAYDKASLYS
ECCCCCCCCHHHHHH		17.65-
259PhosphorylationADVDIILSIPMFLRL
CCHHHHHHHHHHHHH		17.78-
293UbiquitinationRSIGALNKINFNTRF
CCCCHHHHCCCCHHH		39.6221906983
294UbiquitinationSIGALNKINFNTRFV
CCCHHHHCCCCHHHH		7.4721906983
355PhosphorylationAMWLISITFLSIGYG
HHHHHHHHHHHCCCC		16.2524719451
368PhosphorylationYGDMVPNTYCGKGVC
CCCCCCCCCCCCCCH		17.7024719451
401UbiquitinationARKLELTKAEKHVHN
HHHHCCHHHHHHHHH		68.142097226
464PhosphorylationQAIHQLRSVKMEQRK
HHHHHHHHCHHHHHH		34.3816513649
466SumoylationIHQLRSVKMEQRKLN
HHHHHHCHHHHHHHH		37.66-
466SumoylationIHQLRSVKMEQRKLN
HHHHHHCHHHHHHHH		37.66-
484AcetylationNTLVDLAKTQNIMYD
HHHHHHHHHHHHHHH		58.9211688565
516PhosphorylationTLETKLETLIGSIHA
HHHHHHHHHHHHHHH		33.83-
531PhosphorylationLPGLISQTIRQQQRD
HHHHHHHHHHHHHHH		16.01-
553PhosphorylationSYDKHVTYNAERSRS
HHHHHHCCCHHHCCC		15.9927642862
562PhosphorylationAERSRSSSRRRRSSS
HHHCCCCCCCHHCCC		30.93-
566MethylationRSSSRRRRSSSTAPP
CCCCCCHHCCCCCCC		38.7924410459
566DimethylationRSSSRRRRSSSTAPP
CCCCCCHHCCCCCCC		38.79-
567PhosphorylationSSSRRRRSSSTAPPT
CCCCCHHCCCCCCCC		27.1628450419
568PhosphorylationSSRRRRSSSTAPPTS
CCCCHHCCCCCCCCC		29.8728450419
569PhosphorylationSRRRRSSSTAPPTSS
CCCHHCCCCCCCCCC		29.8128450419
570PhosphorylationRRRRSSSTAPPTSSE
CCHHCCCCCCCCCCC		45.1728450419
574PhosphorylationSSSTAPPTSSESS--
CCCCCCCCCCCCC--		43.77-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
135SPhosphorylationKinasePRKACAP17612
GPS
135SPhosphorylationKinasePKA-FAMILY-GPS
464SPhosphorylationKinasePRKACAP17612
GPS
464SPhosphorylationKinasePKA-FAMILY-GPS
567SPhosphorylationKinasePRKACAP17612
GPS
567SPhosphorylationKinasePKA-FAMILY-GPS
568SPhosphorylationKinasePRKACAP17612
GPS
568SPhosphorylationKinasePKA-FAMILY-GPS
569SPhosphorylationKinasePRKACAP17612
GPS
569SPhosphorylationKinasePKA-FAMILY-GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KCNN2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KCNN2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KCNN2_HUMANKCNN2physical
11323678
ACTN2_HUMANACTN2physical
19815520
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB01110Miconazole
DB00721Procaine
Regulatory Network of KCNN2_HUMAN

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Related Literatures of Post-Translational Modification

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