FOXN3_HUMAN - dbPTM
FOXN3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FOXN3_HUMAN
UniProt AC O00409
Protein Name Forkhead box protein N3
Gene Name FOXN3
Organism Homo sapiens (Human).
Sequence Length 490
Subcellular Localization Nucleus .
Protein Description Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints)..
Protein Sequence MGPVMPPSKKPESSGISVSSGLSQCYGGSGFSKALQEDDDLDFSLPDIRLEEGAMEDEELTNLNWLHESKNLLKSFGESVLRSVSPVQDLDDDTPPSPAHSDMPYDARQNPNCKPPYSFSCLIFMAIEDSPTKRLPVKDIYNWILEHFPYFANAPTGWKNSVRHNLSLNKCFKKVDKERSQSIGKGSLWCIDPEYRQNLIQALKKTPYHPHPHVFNTPPTCPQAYQSTSGPPIWPGSTFFKRNGALLQDPDIDAASAMMLLNTPPEIQAGFPPGVIQNGARVLSRGLFPGVRPLPITPIGVTAAMRNGITSCRMRTESEPSCGSPVVSGDPKEDHNYSSAKSSNARSTSPTSDSISSSSSSADDHYEFATKGSQEGSEGSEGSFRSHESPSDTEEDDRKHSQKEPKDSLGDSGYASQHKKRQHFAKARKVPSDTLPLKKRRTEKPPESDDEEMKEAAGSLLHLAGIRSCLNNITNRTAKGQKEQKETTKN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMGPVMPPSKKPESSG
CCCCCCCCCCCCCCC		47.6521406692
14PhosphorylationPSKKPESSGISVSSG
CCCCCCCCCCCCCCC		38.18-
70UbiquitinationLNWLHESKNLLKSFG
CHHHHHHHHHHHHHH		48.94-
83PhosphorylationFGESVLRSVSPVQDL
HHHHHHHCCCCCCCC		23.8430266825
85PhosphorylationESVLRSVSPVQDLDD
HHHHHCCCCCCCCCC		22.1730266825
94PhosphorylationVQDLDDDTPPSPAHS
CCCCCCCCCCCCCCC		44.0630266825
97PhosphorylationLDDDTPPSPAHSDMP
CCCCCCCCCCCCCCC		35.6030266825
101PhosphorylationTPPSPAHSDMPYDAR
CCCCCCCCCCCCCCC		37.4030266825
105PhosphorylationPAHSDMPYDARQNPN
CCCCCCCCCCCCCCC		18.6519690332
167PhosphorylationNSVRHNLSLNKCFKK
HHHHHHCHHHHHHHH		34.9021712546
170UbiquitinationRHNLSLNKCFKKVDK
HHHCHHHHHHHHHCH		46.47-
185UbiquitinationERSQSIGKGSLWCID
HHHHHCCCCCCEECC		43.59-
256PhosphorylationDPDIDAASAMMLLNT
CCCCCHHHHHHHHCC		20.5824043423
263PhosphorylationSAMMLLNTPPEIQAG
HHHHHHCCCHHHHCC		39.9424043423
297PhosphorylationGVRPLPITPIGVTAA
CCCCCCCCCCCHHHH		13.60-
316PhosphorylationITSCRMRTESEPSCG
CCCEEECCCCCCCCC		34.22-
318PhosphorylationSCRMRTESEPSCGSP
CEEECCCCCCCCCCC		54.95-
324PhosphorylationESEPSCGSPVVSGDP
CCCCCCCCCCCCCCC		20.8830576142
337PhosphorylationDPKEDHNYSSAKSSN
CCCCCCCCCCCCCCC		10.6928796482
338PhosphorylationPKEDHNYSSAKSSNA
CCCCCCCCCCCCCCC		29.1828796482
339PhosphorylationKEDHNYSSAKSSNAR
CCCCCCCCCCCCCCC		29.3828796482
342PhosphorylationHNYSSAKSSNARSTS
CCCCCCCCCCCCCCC		28.6526074081
343PhosphorylationNYSSAKSSNARSTSP
CCCCCCCCCCCCCCC		33.5326074081
347PhosphorylationAKSSNARSTSPTSDS
CCCCCCCCCCCCCCC		30.7223927012
348PhosphorylationKSSNARSTSPTSDSI
CCCCCCCCCCCCCCC		32.9223927012
349PhosphorylationSSNARSTSPTSDSIS
CCCCCCCCCCCCCCC		27.6823401153
351PhosphorylationNARSTSPTSDSISSS
CCCCCCCCCCCCCCC		44.9528796482
352PhosphorylationARSTSPTSDSISSSS
CCCCCCCCCCCCCCC		32.5128796482
354PhosphorylationSTSPTSDSISSSSSS
CCCCCCCCCCCCCCC		24.9226657352
356PhosphorylationSPTSDSISSSSSSAD
CCCCCCCCCCCCCCC		28.2823403867
357PhosphorylationPTSDSISSSSSSADD
CCCCCCCCCCCCCCC		32.3523403867
358PhosphorylationTSDSISSSSSSADDH
CCCCCCCCCCCCCCC		27.7023403867
359PhosphorylationSDSISSSSSSADDHY
CCCCCCCCCCCCCCC		30.2023403867
360PhosphorylationDSISSSSSSADDHYE
CCCCCCCCCCCCCCE		31.3423403867
361PhosphorylationSISSSSSSADDHYEF
CCCCCCCCCCCCCEE		37.3523403867
366PhosphorylationSSSADDHYEFATKGS
CCCCCCCCEECCCCC		21.5328796482
370PhosphorylationDDHYEFATKGSQEGS
CCCCEECCCCCCCCC		41.0628796482
383PhosphorylationGSEGSEGSFRSHESP
CCCCCCCCCCCCCCC		17.2724719451
386PhosphorylationGSEGSFRSHESPSDT
CCCCCCCCCCCCCCC		29.6021955146
389PhosphorylationGSFRSHESPSDTEED
CCCCCCCCCCCCHHH		25.0421955146
391PhosphorylationFRSHESPSDTEEDDR
CCCCCCCCCCHHHHH		67.4525849741
393PhosphorylationSHESPSDTEEDDRKH
CCCCCCCCHHHHHHH		45.6821955146
408PhosphorylationSQKEPKDSLGDSGYA
CCCCCCCCCCCCCCH		40.1423312004
412PhosphorylationPKDSLGDSGYASQHK
CCCCCCCCCCHHHHH		31.7228450419
414PhosphorylationDSLGDSGYASQHKKR
CCCCCCCCHHHHHHH		13.6627642862
416PhosphorylationLGDSGYASQHKKRQH
CCCCCCHHHHHHHHH		25.0828450419
432PhosphorylationAKARKVPSDTLPLKK
HHHCCCCCCCCCCCC		46.33-
442PhosphorylationLPLKKRRTEKPPESD
CCCCCCCCCCCCCCC		53.0123186163
448PhosphorylationRTEKPPESDDEEMKE
CCCCCCCCCHHHHHH		57.0226657352
459PhosphorylationEMKEAAGSLLHLAGI
HHHHHHHHHHHHHHH		24.0326714015
487PhosphorylationGQKEQKETTKN----
CHHHHHHHCCC----		50.5422210691
488PhosphorylationQKEQKETTKN-----
HHHHHHHCCC-----		29.6722210691
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FOXN3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FOXN3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FOXN3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MEN1_HUMANMEN1physical
16951149
CHSS3_HUMANCHSY3physical
25609649
CHSS1_HUMANCHSY1physical
25609649
HORN_HUMANHRNRphysical
25609649
KBTB7_HUMANKBTBD7physical
25609649
RFX2_HUMANRFX2physical
28514442
RFX3_HUMANRFX3physical
28514442
RFX1_HUMANRFX1physical
28514442
ZBT34_HUMANZBTB34physical
28514442
FBW1A_HUMANBTRCphysical
28514442
FBW1B_HUMANFBXW11physical
28514442
DDB2_HUMANDDB2physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FOXN3_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85, AND MASSSPECTROMETRY.

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