dbPTM

MY18B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MY18B_HUMAN
UniProt AC	Q8IUG5
Protein Name	Unconventional myosin-XVIIIb
Gene Name	MYO18B
Organism	Homo sapiens (Human).
Sequence Length	2567
Subcellular Localization	Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere. Punctate pattern in undifferentiated myoblasts. Nuclear, on primary cardiomyocytes and adult muscle. A partial sarcomeric location was found in some cardiomyocytes.
Protein Description	May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth..
Protein Sequence	MAISSRLALWEQKIREEDKSPPPSSPPPLFSVIPGGFIKQLVRGTEKEAKEARQRKQLAVASPEREIPEISISQPNSKSSSGTRSGSQQISQDDQSSSPGSSDILGKESEGSRSPDPEQMTSINGEKAQELGSSATPTKKTVPFKRGVRRGDVLLMVAKLDPDSAKPEKTHPHDAPPCKTSPPATDTGKEKKGETSRTPCGSQASTEILAPKAEKTRTGGLGDPGQGTVALKKGEEGQSIVGKGLGTPKTTELKEAEPQGKDRQGTRPQAQGPGEGVRPGKAEKEGAEPTNTVEKGNVSKDVGSEGKHVRPQIPGRKWGGFLGRRSKWDGPQNKKDKEGVLLSKAEKTGEPQTQMEKTSQVQGELGDDLRMGEKAGELRSTTGKAGESWDKKEKMGQPQGKSGNAGEARSQTEKGCEAPKEVSTMVESPAAPGKGGWPGSRGQEAEEPCSRAGDGAGALETELEGPSQPALEKDAERPRIRKENQDGPAPQEEGKGGQSRDSDQAPEDRWYEAEKVWLAQKDGFTLATVLKPDEGTADLPAGRVRLWIDADKTITEVDEEHVHRANPPELDQVEDLASLISVNESSVLNTLLQRYKAQLLHTCTGPDLIVLQPRGPSVPSAGKVPKGRRDGLPAHIGSMAQRAYWALLNQRRDQSIVALGWSGAGKTTCCEQVLEHLVGMAGSVDGRVSVEKIRATFTVLRAFGSVSMAHSRSATRFSMVMSLDFNATGRITAAQLQTMLLEKSRVARQPEGESNFLVFSQMLAGLDLDLRTELNLHQMADSSSFGMGVWSKPEDKQKAAAAFAQLQGAMEMLGISESEQRAVWRVLAAIYHLGAAGACKVGRKQFMRFEWANYAAEALGCEYEELNTATFKHHLRQIIQQMTFGPSRWGLEDEETSSGLKMTGVDCVEGMASGLYQELFAAVVSLINRSFSSHHLSMASIMVVDSPGFQNPRHQGKDRAATFEELCHNYAHERLQLLFYQRTFVSTLQRYQEEGVPVQFDLPDPSPGTTVAVVDQNPSQVRLPAGGGAQDARGLFWVLDEEVHVEGSSDSVVLERLCAAFEKKGAGTEGSSALRTCEQPLQCEIFHQLGWDPVRYDLTGWLHRAKPNLSALDAPQVLHQSKREELRSLFQARAKLPPVCRAVAGLEGTSQQALQRSRMVRRTFASSLAAVRRKAPCSQIKLQMDALTSMIKRSRLHFIHCLVPNPVVESRSGQESPPPPQPGRDKPGAGGPLALDIPALRVQLAGFHILEALRLHRTGYADHMGLTRFRRQFQVLDAPLLKKLMSTSEGIDERKAVEELLETLDLEKKAVAVGHSQVFLKAGVISRLEKQREKLVSQSIVLFQAACKGFLSRQEFKKLKIRRLAAQCIQKNVAVFLAVKDWPWWQLLGSLQPLLSATIGTEQLRAKEEELTTLRRKLEKSEKLRNELRQNTDLLESKIADLTSDLADERFKGDVACQVLESERAERLQAFREVQELKSKHEQVQKKLGDVNKQLEEAQQKIQLNDLERNPTGGADEWQMRFDCAQMENEFLRKRLQQCEERLDSELTARKELEQKLGELQSAYDGAKKMAHQLKRKCHHLTCDLEDTCVLLENQQSRNHELEKKQKKFDLQLAQALGESVFEKGLREKVTQENTSVRWELGQLQQQLKQKEQEASQLKQQVEMLQDHKRELLGSPSLGENCVAGLKERLWKLESSALEQQKIQSQQENTIKQLEQLRQRFELEIERMKQMHQKDREDQEEELEDVRQSCQKRLHQLEMQLEQEYEEKQMVLHEKQDLEGLIGTLCDQIGHRDFDVEKRLRRDLRRTHALLSDVQLLLGTMEDGKTSVSKEELEKVHSQLEQSEAKCEEALKTQKVLTADLESMHSELENMTRNKSLVDEQLYRLQFEKADLLKRIDEDQDDLNELMQKHKDLIAQSAADIGQIQELQLQLEEAKKEKHKLQEQLQVAQMRIEYLEQSTVDRAIVSRQEAVICDLENKTEFQKVQIKRFEVLVIRLRDSLIKMGEELSQAATSESQQRESSQYYQRRLEELKADMEELVQREAEASRRCMELEKYVEELAAVRQTLQTDLETSIRRIADLQAALEEVASSDSDTESVQTAVDCGSSGRKEMDNVSILSSQPEGSLQSWLSCTLSLATDTMRTPSRQSATSSRILSPRINEEAGDTERTQSALALSRARSTNVHSKTSGDKPVSPHFVRRQKYCHFGDGEVLAVQRKSTERLEPASSPLASRSTNTSPLSREKLPSPSAALSEFVEGLRRKRAQRGQGSTLGLEDWPTLPIYQTTGASTLRRGRAGSDEGNLSLRVGAKSPLEIEGAAGGLLRSTSLKCISSDGVGGTTLLPEKSKTQFSSCESLLESRPSMGRKLSSPTTPRDMLLSPTLRPRRRCLESSVDDAGCPDLGKEPLVFQNRQFAHLMEEPLGSDPFSWKLPSLDYERKTKVDFDDFLPAIRKPQTPTSLAGSAKGGQDGSQRSSIHFETEEANRSFLSGIKTILKKSPEPKEDPAHLSDSSSSSGSIVSFKSADSIKSRPGIPRLAGDGGERTSPERREPGTGRKDDDVASIMKKYLQK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	KIREEDKSPPPSSPP HHHHHCCCCCCCCCC	55.77	27690223
24	Phosphorylation	EDKSPPPSSPPPLFS HCCCCCCCCCCCCEE	62.34	27690223
25	Phosphorylation	DKSPPPSSPPPLFSV CCCCCCCCCCCCEEE	47.39	27690223
31	Phosphorylation	SSPPPLFSVIPGGFI CCCCCCEEECCCCHH	27.16	27690223
56	Acetylation	AKEARQRKQLAVASP HHHHHHHHHHHHCCC	41.13	7834111
62	Phosphorylation	RKQLAVASPEREIPE HHHHHHCCCCCCCCC	22.24	26437602
71	Phosphorylation	EREIPEISISQPNSK CCCCCCEECCCCCCC	17.96	30266825
73	Phosphorylation	EIPEISISQPNSKSS CCCCEECCCCCCCCC	32.56	30266825
97	Phosphorylation	ISQDDQSSSPGSSDI CCCCCCCCCCCCCCC	34.61	27690223
98	Phosphorylation	SQDDQSSSPGSSDIL CCCCCCCCCCCCCCC	38.23	27690223
101	Phosphorylation	DQSSSPGSSDILGKE CCCCCCCCCCCCCCC	28.37	27690223
102	Phosphorylation	QSSSPGSSDILGKES CCCCCCCCCCCCCCC	34.29	27690223
114	Phosphorylation	KESEGSRSPDPEQMT CCCCCCCCCCHHHCC	35.04	26437602
121	Phosphorylation	SPDPEQMTSINGEKA CCCHHHCCCCCCHHH	26.58	-
133	Phosphorylation	EKAQELGSSATPTKK HHHHHHCCCCCCCCC	29.44	-
134	Phosphorylation	KAQELGSSATPTKKT HHHHHCCCCCCCCCC	34.07	-
136	Phosphorylation	QELGSSATPTKKTVP HHHCCCCCCCCCCCC	33.18	-
138	Phosphorylation	LGSSATPTKKTVPFK HCCCCCCCCCCCCCC	40.60	-
164	Phosphorylation	VAKLDPDSAKPEKTH EEECCCCCCCCCCCC	43.51	20068231
180	Phosphorylation	HDAPPCKTSPPATDT CCCCCCCCCCCCCCC	53.86	27690223
181	Phosphorylation	DAPPCKTSPPATDTG CCCCCCCCCCCCCCC	17.87	27690223
185	Phosphorylation	CKTSPPATDTGKEKK CCCCCCCCCCCCCCC	39.61	-
198	Phosphorylation	KKGETSRTPCGSQAS CCCCCCCCCCCCHHH	23.77	20068231
202	Phosphorylation	TSRTPCGSQASTEIL CCCCCCCCHHHCEEE	29.32	20068231
205	Phosphorylation	TPCGSQASTEILAPK CCCCCHHHCEEECCC	20.95	20068231
206	Phosphorylation	PCGSQASTEILAPKA CCCCHHHCEEECCCC	30.02	20068231
239	Phosphorylation	KKGEEGQSIVGKGLG ECCCCCCCCCCCCCC	30.05	22468782
247	Phosphorylation	IVGKGLGTPKTTELK CCCCCCCCCCCCCHH	27.01	24719451
250	Phosphorylation	KGLGTPKTTELKEAE CCCCCCCCCCHHHCC	27.06	22468782
251	Phosphorylation	GLGTPKTTELKEAEP CCCCCCCCCHHHCCC	45.51	22468782
392	Acetylation	AGESWDKKEKMGQPQ CCCCCCHHHHCCCCC	61.16	130765
392	Ubiquitination	AGESWDKKEKMGQPQ CCCCCCHHHHCCCCC	61.16	-
394	Acetylation	ESWDKKEKMGQPQGK CCCCHHHHCCCCCCC	58.15	130761
394	Ubiquitination	ESWDKKEKMGQPQGK CCCCHHHHCCCCCCC	58.15	-
401	Acetylation	KMGQPQGKSGNAGEA HCCCCCCCCCCHHHH	50.36	130763
401	Ubiquitination	KMGQPQGKSGNAGEA HCCCCCCCCCCHHHH	50.36	-
402	Phosphorylation	MGQPQGKSGNAGEAR CCCCCCCCCCHHHHH	44.07	-
423	Phosphorylation	CEAPKEVSTMVESPA CCCCCCCCHHHCCCC	16.33	30266825
424	Phosphorylation	EAPKEVSTMVESPAA CCCCCCCHHHCCCCC	30.34	30266825
428	Phosphorylation	EVSTMVESPAAPGKG CCCHHHCCCCCCCCC	14.39	30266825
440	Phosphorylation	GKGGWPGSRGQEAEE CCCCCCCCCCCCCCC	29.20	-
502	Phosphorylation	KGGQSRDSDQAPEDR CCCCCCCCCCCCCCH	30.43	-
511	Phosphorylation	QAPEDRWYEAEKVWL CCCCCHHHHHHHHEE	13.22	-
536	Phosphorylation	VLKPDEGTADLPAGR EECCCCCCCCCCCCE	18.23	25367160
590	Phosphorylation	NESSVLNTLLQRYKA CHHHHHHHHHHHHHH	25.37	28857561
617	Phosphorylation	VLQPRGPSVPSAGKV EEECCCCCCCCCCCC	49.86	29449344
620	Phosphorylation	PRGPSVPSAGKVPKG CCCCCCCCCCCCCCC	47.71	29449344
711	Phosphorylation	GSVSMAHSRSATRFS CCHHHCCCCCCCEEE	20.56	22210691
715	Phosphorylation	MAHSRSATRFSMVMS HCCCCCCCEEEEEEE	33.23	-
730	Methylation	LDFNATGRITAAQLQ ECCCCCCCCCHHHHH	20.80	115387543
732	Phosphorylation	FNATGRITAAQLQTM CCCCCCCCHHHHHHH	17.99	22210691
1068	Phosphorylation	FEKKGAGTEGSSALR HHHCCCCCCCCHHHH	36.32	20068231
1071	Phosphorylation	KGAGTEGSSALRTCE CCCCCCCCHHHHHCC	13.25	20068231
1072	Phosphorylation	GAGTEGSSALRTCEQ CCCCCCCHHHHHCCC	42.02	20068231
1178	Phosphorylation	VRRKAPCSQIKLQMD HHHHCCHHHHHHHHH	33.60	22210691
1188	Phosphorylation	KLQMDALTSMIKRSR HHHHHHHHHHHHHHC	20.26	-
1189	Phosphorylation	LQMDALTSMIKRSRL HHHHHHHHHHHHHCC	21.25	22210691
1212	Phosphorylation	NPVVESRSGQESPPP CCCCCCCCCCCCCCC	54.85	30266825
1216	Phosphorylation	ESRSGQESPPPPQPG CCCCCCCCCCCCCCC	34.52	30266825
1286	Phosphorylation	PLLKKLMSTSEGIDE HHHHHHHCCCCCCCH	38.94	-
1287	Phosphorylation	LLKKLMSTSEGIDER HHHHHHCCCCCCCHH	19.48	-
1288	Phosphorylation	LKKLMSTSEGIDERK HHHHHCCCCCCCHHH	26.90	-
1326	Phosphorylation	FLKAGVISRLEKQRE HHHHHHHHHHHHHHH	28.54	24719451
1337	Phosphorylation	KQREKLVSQSIVLFQ HHHHHHHHHHHHHHH	28.75	22210691
1339	Phosphorylation	REKLVSQSIVLFQAA HHHHHHHHHHHHHHH	13.73	22210691
1352	Phosphorylation	AACKGFLSRQEFKKL HHHHHHCCHHHHHHH	29.65	22210691
1432	Phosphorylation	RNELRQNTDLLESKI HHHHHHCHHHHHHHH	21.49	21712546
1437	Phosphorylation	QNTDLLESKIADLTS HCHHHHHHHHHHHHH	29.36	21712546
1564	Phosphorylation	LGELQSAYDGAKKMA HHHHHHHHHHHHHHH	21.84	-
1675	Phosphorylation	HKRELLGSPSLGENC HHHHHHCCCCHHCCH	15.98	19690332
1829	Phosphorylation	EDGKTSVSKEELEKV CCCCCCCCHHHHHHH	33.83	18669648
1838	Phosphorylation	EELEKVHSQLEQSEA HHHHHHHHHHHHHHH	39.17	30622161
1855	Acetylation	EEALKTQKVLTADLE HHHHHHHHHHHHHHH	44.43	19815633
1999	Phosphorylation	LVIRLRDSLIKMGEE EEEECHHHHHHHHHH	26.09	24719451
2055	Phosphorylation	RCMELEKYVEELAAV HHHHHHHHHHHHHHH	12.06	-
2072	Phosphorylation	TLQTDLETSIRRIAD HHHHHHHHHHHHHHH	36.43	-
2073	Phosphorylation	LQTDLETSIRRIADL HHHHHHHHHHHHHHH	12.53	-
2127	Phosphorylation	QPEGSLQSWLSCTLS CCCCCHHHHHHHHHH	34.97	-
2132	Phosphorylation	LQSWLSCTLSLATDT HHHHHHHHHHHHHCC	18.92	-
2134	Phosphorylation	SWLSCTLSLATDTMR HHHHHHHHHHHCCCC	9.60	-
2142	Phosphorylation	LATDTMRTPSRQSAT HHHCCCCCCCCCCCC	18.13	-
2144	Phosphorylation	TDTMRTPSRQSATSS HCCCCCCCCCCCCCC	42.19	-
2147	Phosphorylation	MRTPSRQSATSSRIL CCCCCCCCCCCCCCC	32.19	26546556
2149	Phosphorylation	TPSRQSATSSRILSP CCCCCCCCCCCCCCC	32.27	26546556
2150	Phosphorylation	PSRQSATSSRILSPR CCCCCCCCCCCCCCC	19.82	26546556
2155	Phosphorylation	ATSSRILSPRINEEA CCCCCCCCCCCCCCC	15.12	24719451
2168	Phosphorylation	EAGDTERTQSALALS CCCCCHHHHHHHHHH	22.20	26437602
2170	Phosphorylation	GDTERTQSALALSRA CCCHHHHHHHHHHHH	25.33	26437602
2175	Phosphorylation	TQSALALSRARSTNV HHHHHHHHHHHHCCC	20.49	24719451
2186	Phosphorylation	STNVHSKTSGDKPVS HCCCCCCCCCCCCCC	40.74	26434776
2187	Phosphorylation	TNVHSKTSGDKPVSP CCCCCCCCCCCCCCH	49.05	26434776
2193	Phosphorylation	TSGDKPVSPHFVRRQ CCCCCCCCHHHHCCC	22.61	30576142
2217	Phosphorylation	VLAVQRKSTERLEPA EEEEEECCCCCCCCC	37.38	26437602
2225	Phosphorylation	TERLEPASSPLASRS CCCCCCCCCCCCCCC	43.11	25072903
2226	Phosphorylation	ERLEPASSPLASRST CCCCCCCCCCCCCCC	26.49	25072903
2230	Phosphorylation	PASSPLASRSTNTSP CCCCCCCCCCCCCCC	34.15	25072903
2232	Phosphorylation	SSPLASRSTNTSPLS CCCCCCCCCCCCCCC	24.42	26437602
2233	Phosphorylation	SPLASRSTNTSPLSR CCCCCCCCCCCCCCH	41.21	22673903
2235	Phosphorylation	LASRSTNTSPLSREK CCCCCCCCCCCCHHC	31.63	22673903
2236	Phosphorylation	ASRSTNTSPLSREKL CCCCCCCCCCCHHCC	26.39	30576142
2239	Phosphorylation	STNTSPLSREKLPSP CCCCCCCCHHCCCCH	41.60	22673903
2245	Phosphorylation	LSREKLPSPSAALSE CCHHCCCCHHHHHHH	41.76	26434776
2247	Phosphorylation	REKLPSPSAALSEFV HHCCCCHHHHHHHHH	30.43	20068231
2251	Phosphorylation	PSPSAALSEFVEGLR CCHHHHHHHHHHHHH	25.02	26434776
2268	Phosphorylation	RAQRGQGSTLGLEDW HHHCCCCCCCCCCCC	16.75	-
2284	Phosphorylation	TLPIYQTTGASTLRR CCCEEEECCCCHHCC	18.41	-
2288	Phosphorylation	YQTTGASTLRRGRAG EEECCCCHHCCCCCC	24.61	-
2296	Phosphorylation	LRRGRAGSDEGNLSL HCCCCCCCCCCCEEE	31.35	25884760
2309	Phosphorylation	SLRVGAKSPLEIEGA EEEECCCCCCEECCC	33.90	28060719
2325	Phosphorylation	GGLLRSTSLKCISSD CCHHHCCCCEEEECC	27.38	22210691
2330	Phosphorylation	STSLKCISSDGVGGT CCCCEEEECCCCCCC	31.67	22210691
2337	Phosphorylation	SSDGVGGTTLLPEKS ECCCCCCCCCCCCCC	14.35	22210691
2346	Phosphorylation	LLPEKSKTQFSSCES CCCCCCCCCCCCHHH	41.77	26437602
2350	Phosphorylation	KSKTQFSSCESLLES CCCCCCCCHHHHHHH	24.16	26437602
2366	Phosphorylation	PSMGRKLSSPTTPRD CCCCCCCCCCCCCHH	36.99	30266825
2367	Phosphorylation	SMGRKLSSPTTPRDM CCCCCCCCCCCCHHH	36.38	30266825
2369	Phosphorylation	GRKLSSPTTPRDMLL CCCCCCCCCCHHHCC	51.91	30266825
2370	Phosphorylation	RKLSSPTTPRDMLLS CCCCCCCCCHHHCCC	21.51	30266825
2377	Phosphorylation	TPRDMLLSPTLRPRR CCHHHCCCCCCCCCH	16.33	30266825
2379	Phosphorylation	RDMLLSPTLRPRRRC HHHCCCCCCCCCHHH	31.83	23186163
2453	Phosphorylation	PAIRKPQTPTSLAGS HHHCCCCCCCCCCCC	36.74	26437602
2455	Phosphorylation	IRKPQTPTSLAGSAK HCCCCCCCCCCCCCC	39.50	18088087
2471	Phosphorylation	GQDGSQRSSIHFETE CCCCCCCCCEEECCH	26.46	26437602
2472	Phosphorylation	QDGSQRSSIHFETEE CCCCCCCCEEECCHH	23.44	26437602
2490	Phosphorylation	SFLSGIKTILKKSPE HHHHHHHHHHHHCCC	29.62	26437602
2495	Phosphorylation	IKTILKKSPEPKEDP HHHHHHHCCCCCCCC	32.67	22817900
2541	Phosphorylation	AGDGGERTSPERREP CCCCCCCCCCCCCCC	44.31	26437602
2542	Phosphorylation	GDGGERTSPERREPG CCCCCCCCCCCCCCC	30.87	26437602

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MY18B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MY18B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MY18B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MY18B_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MY18B_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1829, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164 AND SER-2495, ANDMASS SPECTROMETRY.	17081983 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2020; THR-2453 ANDTHR-2455, AND MASS SPECTROMETRY.	18088087 [Abstract]