dbPTM

PDE7B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PDE7B_HUMAN
UniProt AC	Q9NP56
Protein Name	cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Gene Name	PDE7B
Organism	Homo sapiens (Human).
Sequence Length	450
Subcellular Localization
Protein Description	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain..
Protein Sequence	MSCLMVERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYPFIDFRLLNSTTYSGEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQHRSRGSSGSGPDHDHAGQGTESEEQEGDSP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Phosphorylation	VRAERRGSYPFIDFR CCCHHHCCCCEEEEE	28.02	22617229
46	Phosphorylation	RAERRGSYPFIDFRL CCHHHCCCCEEEEEE	12.65	23403867
58	Phosphorylation	FRLLNSTTYSGEIGT EEEECCCCCCCCCCC	18.60	23403867
60	Phosphorylation	LLNSTTYSGEIGTKK EECCCCCCCCCCCHH	28.05	23403867
74	Phosphorylation	KKVKRLLSFQRYFHA HHHHHHHHHHHHHHH	24.75	23401153
82	Phosphorylation	FQRYFHASRLLRGII HHHHHHHHHHHCCCC	18.19	20860994
268	Phosphorylation	AHLPKEMTQDIEQQL HCCCHHHHHHHHHHH	24.96	25850435
277	Phosphorylation	DIEQQLGSLILATDI HHHHHHHHHHHHHCC	22.34	28258704
282	Phosphorylation	LGSLILATDINRQNE HHHHHHHHCCCHHHH	33.69	28258704
295	Ubiquitination	NEFLTRLKAHLHNKD HHHHHHHHHHHCCCC	30.39	29967540
301	Ubiquitination	LKAHLHNKDLRLEDA HHHHHCCCCCCCHHH	47.60	29967540
426	Phosphorylation	RQHRSRGSSGSGPDH HHHHCCCCCCCCCCC	30.34	-
427	Phosphorylation	QHRSRGSSGSGPDHD HHHCCCCCCCCCCCC	39.54	21955146
442	Phosphorylation	HAGQGTESEEQEGDS CCCCCCCCCCCCCCC	46.39	33259812

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PDE7B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PDE7B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PDE7B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PDE7B_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00201	Caffeine
DB00651	Dyphylline
DB00920	Ketotifen

Regulatory Network of PDE7B_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45, AND MASSSPECTROMETRY.	18220336 [Abstract]