D42E1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: D42E1_HUMAN
• UniProt AC: Q8WUS8
• Protein Name: Short-chain dehydrogenase/reductase family 42E member 1 {ECO:0000303|PubMed:19027726}
• Gene Name: SDR42E1
• Organism: Homo sapiens (Human).
• Sequence Length: 393
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MDPKRSQKESVLITGGSGYFGFRLGCALNQNGVHVILFDISSPAQTIPEGIKFIQGDIRHLSDVEKAFQDADVTCVFHIASYGMSGREQLNRNLIKEVNVRGTDNILQVCQRRRVPRLVYTSTFNVIFGGQVIRNGDESLPYLPLHLHPDHYSRTKSIAEQKVLEANATPLDRGDGVLRTCALRPAGIYGPGEQRHLPRIVSYIEKGLFKFVYGDPRSLVEFVHVDNLVQAHILASEALRADKGHIASGQPYFISDGRPVNNFEFFRPLVEGLGYTFPSTRLPLTLVYCFAFLTEMVHFILGRLYNFQPFLTRTEVYKTGVTHYFSLEKAKKELGYKAQPFDLQEAVEWFKAHGHGRSSGSRDSECFVWDGLLVFLLIIAVLMWLPSSVILSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MDPKRSQKESVLI --CCCCHHCCCEEEE	52.29	27134283
10	Phosphorylation	PKRSQKESVLITGGS CCHHCCCEEEEECCC	29.29	27134283
14	Phosphorylation	QKESVLITGGSGYFG CCCEEEEECCCCCHH	31.18	27134283
85	Phosphorylation	HIASYGMSGREQLNR EHHHCCCCHHHHHHH	30.27	-
93	Ubiquitination	GREQLNRNLIKEVNV HHHHHHHHHHHHHCC	45.07	22817900
96	Ubiquitination	QLNRNLIKEVNVRGT HHHHHHHHHHCCCCC	59.79	21906983
139	Phosphorylation	VIRNGDESLPYLPLH EEECCCCCCCCCCCC	39.11	-
153	Ubiquitination	HLHPDHYSRTKSIAE CCCCCCCCCCHHHHH	30.01	27667366
155	Phosphorylation	HPDHYSRTKSIAEQK CCCCCCCCHHHHHHH	24.17	-
156	Ubiquitination	PDHYSRTKSIAEQKV CCCCCCCHHHHHHHH	38.46	27667366
159	Ubiquitination	YSRTKSIAEQKVLEA CCCCHHHHHHHHHHH	21.91	22817900
162	Ubiquitination	TKSIAEQKVLEANAT CHHHHHHHHHHHCCC	40.05	21906983
202	Phosphorylation	RHLPRIVSYIEKGLF CCHHHHHHHHHHCCC	20.30	-
203	Phosphorylation	HLPRIVSYIEKGLFK CHHHHHHHHHHCCCH	11.38	-
315	Ubiquitination	QPFLTRTEVYKTGVT CCCEEEEEHHHCCCC	40.33	22817900
318	Ubiquitination	LTRTEVYKTGVTHYF EEEEEHHHCCCCEEE	43.93	21906983
322	Phosphorylation	EVYKTGVTHYFSLEK EHHHCCCCEEEEHHH	16.53	27135362
326	Phosphorylation	TGVTHYFSLEKAKKE CCCCEEEEHHHHHHH	28.58	27135362
328	Ubiquitination	VTHYFSLEKAKKELG CCEEEEHHHHHHHHC	50.17	23503661
329	Ubiquitination	THYFSLEKAKKELGY CEEEEHHHHHHHHCC	71.45	22817900
331	Ubiquitination	YFSLEKAKKELGYKA EEEHHHHHHHHCCCC	58.82	23503661
332	Ubiquitination	FSLEKAKKELGYKAQ EEHHHHHHHHCCCCC	64.13	22817900
334	Ubiquitination	LEKAKKELGYKAQPF HHHHHHHHCCCCCCC	14.43	22817900
337	Ubiquitination	AKKELGYKAQPFDLQ HHHHHCCCCCCCCHH	38.45	21906983
348	Ubiquitination	FDLQEAVEWFKAHGH CCHHHHHHHHHHCCC	55.00	23503661
351	Ubiquitination	QEAVEWFKAHGHGRS HHHHHHHHHCCCCCC	40.31	23503661

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of D42E1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of D42E1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of D42E1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of D42E1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.