PPIL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PPIL1_HUMAN
• UniProt AC: Q9Y3C6
• Protein Name: Peptidyl-prolyl cis-trans isomerase-like 1
• Gene Name: PPIL1
• Organism: Homo sapiens (Human).
• Sequence Length: 166
• Subcellular Localization: Nucleus .
• Protein Description: Involved in pre-mRNA splicing as component of the spliceosome. [PubMed: 11991638]
• Protein Sequence: MAAIPPDSWQPPNVYLETSMGIIVLELYWKHAPKTCKNFAELARRGYYNGTKFHRIIKDFMIQGGDPTGTGRGGASIYGKQFEDELHPDLKFTGAGILAMANAGPDTNGSQFFVTLAPTQWLDGKHTIFGRVCQGIGMVNRVGMVETNSQDRPVDDVKIIKAYPSG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Acetylation	KHAPKTCKNFAELAR HHCCHHHHCHHHHHH	61.40	26051181
37	Ubiquitination	KHAPKTCKNFAELAR HHCCHHHHCHHHHHH	61.40	-
51	Phosphorylation	RRGYYNGTKFHRIIK HCCCCCCCCHHHHHH	27.22	28387310
52	Acetylation	RGYYNGTKFHRIIKD CCCCCCCCHHHHHHH	40.34	27452117
52	Ubiquitination	RGYYNGTKFHRIIKD CCCCCCCCHHHHHHH	40.34	-
58	Acetylation	TKFHRIIKDFMIQGG CCHHHHHHHHEEECC	42.41	26051181
58	Ubiquitination	TKFHRIIKDFMIQGG CCHHHHHHHHEEECC	42.41	21890473
68	Phosphorylation	MIQGGDPTGTGRGGA EEECCCCCCCCCCCC	52.71	21406692
70	Phosphorylation	QGGDPTGTGRGGASI ECCCCCCCCCCCCEE	26.61	21406692
72	Methylation	GDPTGTGRGGASIYG CCCCCCCCCCCEEEC	39.96	30988927
76	Phosphorylation	GTGRGGASIYGKQFE CCCCCCCEEECCCCC	21.44	21406692
78	Phosphorylation	GRGGASIYGKQFEDE CCCCCEEECCCCCCC	18.77	21406692
80	Ubiquitination	GGASIYGKQFEDELH CCCEEECCCCCCCCC	34.54	21890473
80	Acetylation	GGASIYGKQFEDELH CCCEEECCCCCCCCC	34.54	23236377
125	Ubiquitination	PTQWLDGKHTIFGRV CCCCCCCCCCCHHHH	36.92	-
138	Sulfoxidation	RVCQGIGMVNRVGMV HHCCCCCCCCCEEEE	1.97	21406390
144	Sulfoxidation	GMVNRVGMVETNSQD CCCCCEEEEEECCCC	1.94	21406390
147	Phosphorylation	NRVGMVETNSQDRPV CCEEEEEECCCCCCC	28.85	30266825
149	Phosphorylation	VGMVETNSQDRPVDD EEEEEECCCCCCCCC	40.66	30266825
158	Acetylation	DRPVDDVKIIKAYPS CCCCCCCEEEECCCC	45.79	25953088
161	Ubiquitination	VDDVKIIKAYPSG-- CCCCEEEECCCCC--	45.39	-
161	Sumoylation	VDDVKIIKAYPSG-- CCCCEEEECCCCC--	45.39	-
161	Sumoylation	VDDVKIIKAYPSG-- CCCCEEEECCCCC--	45.39	-
163	Phosphorylation	DVKIIKAYPSG---- CCEEEECCCCC----	7.91	29496907

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PPIL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PPIL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PPIL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GA45G_HUMAN	GADD45G	physical	15383276
SF3B3_HUMAN	SF3B3	physical	22365833
ROA1_HUMAN	HNRNPA1	physical	22365833
WDR83_HUMAN	WDR83	physical	22365833
THOC5_HUMAN	THOC5	physical	22365833
PP1R8_HUMAN	PPP1R8	physical	22365833
HNRL1_HUMAN	HNRNPUL1	physical	22365833
MEP50_HUMAN	WDR77	physical	22365833
RBM42_HUMAN	RBM42	physical	22365833
RIM3A_HUMAN	RIMBP3	physical	25416956
PRR22_HUMAN	PRR22	physical	25416956
SNW1_HUMAN	SNW1	physical	26344197
GPAM1_HUMAN	GPALPP1	physical	28514442
SNW1_HUMAN	SNW1	physical	28514442
DEOC_HUMAN	DERA	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.