DEOC_HUMAN - dbPTM
DEOC_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DEOC_HUMAN
UniProt AC Q9Y315
Protein Name Deoxyribose-phosphate aldolase
Gene Name DERA
Organism Homo sapiens (Human).
Sequence Length 318
Subcellular Localization Cytoplasm . Cytoplasmic granule . Nucleus . Recruited to stress granules but not to processing bodies upon arsenite or clotrimazole treatment or energy deprivation.
Protein Description Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation..
Protein Sequence MSAHNRGTELDLSWISKIQVNHPAVLRRAEQIQARRTVKKEWQAAWLLKAVTFIDLTTLSGDDTSSNIQRLCYKAKYPIREDLLKALNMHDKGITTAAVCVYPARVCDAVKALKAAGCNIPVASVAAGFPAGQTHLKTRLEEIRLAVEDGATEIDVVINRSLVLTGQWEALYDEIRQFRKACGEAHLKTILATGELGTLTNVYKASMIAMMAGSDFIKTSTGKETVNATFPVAIVMLRAIRDFFWKTGNKIGFKPAGGIRSAKDSLAWLSLVKEELGDEWLKPELFRIGASTLLSDIERQIYHHVTGRYAAYHDLPMS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMSAHNRGTELDLSWI
CCCCCCCCCCCHHHH		30.0920068231
13PhosphorylationRGTELDLSWISKIQV
CCCCCCHHHHHHCCC		23.2520068231
16PhosphorylationELDLSWISKIQVNHP
CCCHHHHHHCCCCCH		19.9024719451
89SulfoxidationDLLKALNMHDKGITT
HHHHHCCCCCCCCCE		4.5030846556
111AcetylationARVCDAVKALKAAGC
HHHHHHHHHHHHCCC		50.1225953088
111UbiquitinationARVCDAVKALKAAGC
HHHHHHHHHHHHCCC		50.12-
114UbiquitinationCDAVKALKAAGCNIP
HHHHHHHHHCCCCCC		40.84-
218AcetylationMAGSDFIKTSTGKET
HHCCCCEECCCCCCC		36.097365683
219PhosphorylationAGSDFIKTSTGKETV
HCCCCEECCCCCCCC		27.0628509920
220PhosphorylationGSDFIKTSTGKETVN
CCCCEECCCCCCCCC		30.1128509920
221PhosphorylationSDFIKTSTGKETVNA
CCCEECCCCCCCCCC		58.4628509920
225PhosphorylationKTSTGKETVNATFPV
ECCCCCCCCCCCHHH		23.6520068231
229PhosphorylationGKETVNATFPVAIVM
CCCCCCCCHHHHHHH		24.2225072903
254UbiquitinationTGNKIGFKPAGGIRS
CCCCCCCCCCCCCCC		28.83-
261PhosphorylationKPAGGIRSAKDSLAW
CCCCCCCCHHHHHHH		37.4418187866
263UbiquitinationAGGIRSAKDSLAWLS
CCCCCCHHHHHHHHH		49.4421906983
270PhosphorylationKDSLAWLSLVKEELG
HHHHHHHHHHHHHHC		22.0324719451
282UbiquitinationELGDEWLKPELFRIG
HHCCCCCCHHHHHHC		37.202190698
291PhosphorylationELFRIGASTLLSDIE
HHHHHCHHHHHHHHH		17.8629255136
292PhosphorylationLFRIGASTLLSDIER
HHHHCHHHHHHHHHH		31.0529255136
295PhosphorylationIGASTLLSDIERQIY
HCHHHHHHHHHHHHH		39.39-
302PhosphorylationSDIERQIYHHVTGRY
HHHHHHHHHHHHCCC		4.23-
309PhosphorylationYHHVTGRYAAYHDLP
HHHHHCCCHHHCCCC		9.2729496907
312PhosphorylationVTGRYAAYHDLPMS-
HHCCCHHHCCCCCC-		6.4127642862
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DEOC_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DEOC_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DEOC_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NEK6_HUMANNEK6physical
22939629
CBS_HUMANCBSphysical
22863883
GDE_HUMANAGLphysical
26344197
A16A1_HUMANALDH16A1physical
26344197
ARMT1_HUMANC6orf211physical
26344197
ASPC1_HUMANASPSCR1physical
26344197
PUR9_HUMANATICphysical
26344197
PNPH_HUMANPNPphysical
26344197
PNPO_HUMANPNPOphysical
26344197
TYPH_HUMANTYMPphysical
26344197
Drug and Disease Associations
Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DEOC_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-261, AND MASSSPECTROMETRY.

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