LDHC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LDHC_HUMAN
• UniProt AC: P07864
• Protein Name: L-lactate dehydrogenase C chain
• Gene Name: LDHC
• Organism: Homo sapiens (Human).
• Sequence Length: 332
• Subcellular Localization: Cytoplasm.
• Protein Description: Possible role in sperm motility..
• Protein Sequence: MSTVKEQLIEKLIEDDENSQCKITIVGTGAVGMACAISILLKDLADELALVDVALDKLKGEMMDLQHGSLFFSTSKITSGKDYSVSANSRIVIVTAGARQQEGETRLALVQRNVAIMKSIIPAIVHYSPDCKILVVSNPVDILTYIVWKISGLPVTRVIGSGCNLDSARFRYLIGEKLGVHPTSCHGWIIGEHGDSSVPLWSGVNVAGVALKTLDPKLGTDSDKEHWKNIHKQVIQSAYEIIKLKGYTSWAIGLSVMDLVGSILKNLRRVHPVSTMVKGLYGIKEELFLSIPCVLGRNGVSDVVKINLNSEEEALFKKSAETLWNIQKDLIF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Acetylation	VKEQLIEKLIEDDEN HHHHHHHHHHHCCCC	48.01	25038526
19	Phosphorylation	LIEDDENSQCKITIV HHHCCCCCCEEEEEE	34.60	30622161
24	Phosphorylation	ENSQCKITIVGTGAV CCCCEEEEEECCHHH	8.63	24260401
28	Phosphorylation	CKITIVGTGAVGMAC EEEEEECCHHHHHHH	15.86	24260401
38	Phosphorylation	VGMACAISILLKDLA HHHHHHHHHHHHHHH	6.67	-
57	Acetylation	LVDVALDKLKGEMMD HHHHHHHHHCCCCCC	53.61	25038526
59	Acetylation	DVALDKLKGEMMDLQ HHHHHHHCCCCCCCC	59.57	20167786
73	Phosphorylation	QHGSLFFSTSKITSG CCCCEEEECCCCCCC	25.16	-
75	Phosphorylation	GSLFFSTSKITSGKD CCEEEECCCCCCCCC	22.36	-
84	Phosphorylation	ITSGKDYSVSANSRI CCCCCCEEECCCCEE	21.52	29496907
95	Phosphorylation	NSRIVIVTAGARQQE CCEEEEEECCCCCCC	14.30	20068231
137	Phosphorylation	DCKILVVSNPVDILT CCEEEEECCCHHHHH	28.12	-
151	Phosphorylation	TYIVWKISGLPVTRV HHHHHHHHCCCCEEE	30.47	20860994
161	Phosphorylation	PVTRVIGSGCNLDSA CCEEEECCCCCCCHH	29.11	24114839
163	S-palmitoylation	TRVIGSGCNLDSARF EEEECCCCCCCHHHH	4.97	29575903
167	Phosphorylation	GSGCNLDSARFRYLI CCCCCCCHHHHHHHH	25.22	21712546
169	Methylation	GCNLDSARFRYLIGE CCCCCHHHHHHHHCC	22.11	-
177	Acetylation	FRYLIGEKLGVHPTS HHHHHCCCCCCCCCC	45.38	25038526
220	Phosphorylation	TLDPKLGTDSDKEHW HCCCCCCCCCCHHHH	42.65	21406692
222	Phosphorylation	DPKLGTDSDKEHWKN CCCCCCCCCHHHHHH	50.88	21406692
243	Acetylation	QSAYEIIKLKGYTSW HHHHHHHHHCCCCHH	50.21	25038526
245	Ubiquitination	AYEIIKLKGYTSWAI HHHHHHHCCCCHHHH	44.89	-
249	Phosphorylation	IKLKGYTSWAIGLSV HHHCCCCHHHHHHHH	13.16	-
262	Phosphorylation	SVMDLVGSILKNLRR HHHHHHHHHHHHCCC	19.78	24719451
269	Methylation	SILKNLRRVHPVSTM HHHHHCCCCCCHHHH	33.97	115481985
275	Phosphorylation	RRVHPVSTMVKGLYG CCCCCHHHHHHCHHC	26.64	-
278	Methylation	HPVSTMVKGLYGIKE CCHHHHHHCHHCCCH	32.17	115972463
284	Acetylation	VKGLYGIKEELFLSI HHCHHCCCHHHHHHC	40.55	25038526
301	Phosphorylation	VLGRNGVSDVVKINL ECCCCCCCCEEEECC	26.53	29632367
310	Phosphorylation	VVKINLNSEEEALFK EEEECCCCHHHHHHH	49.94	30622161
317	Acetylation	SEEEALFKKSAETLW CHHHHHHHHHHHHHH	46.82	25038526
322	Phosphorylation	LFKKSAETLWNIQKD HHHHHHHHHHHHHHH	36.47	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LDHC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LDHC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LDHC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARF4_HUMAN	ARF4	physical	26344197
ARF5_HUMAN	ARF5	physical	26344197
MDHC_HUMAN	MDH1	physical	26344197
NDKB_HUMAN	NME2	physical	26344197
TALDO_HUMAN	TALDO1	physical	26344197
TPIS_HUMAN	TPI1	physical	26344197
UBE2N_HUMAN	UBE2N	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.