STON1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STON1_HUMAN
• UniProt AC: Q9Y6Q2
• Protein Name: Stonin-1
• Gene Name: STON1
• Organism: Homo sapiens (Human).
• Sequence Length: 735
• Subcellular Localization: Cytoplasm . Membrane . Some fraction is membrane-associated.
• Protein Description: May be involved in the endocytic machinery..
• Protein Sequence: MCSTNPGKWVTFDDDPAVQSSQKSKNFPLENQGVCRPNGLKLNLPGLREFPSGSSSTSSTPLSSPIVDFYFSPGPPSNSPLSTPTKDFPGFPGIPKAGTHVLYPIPESSSDSPLAISGGESSLLPTRPTCLSHALLPSDHSCTHPTPKVGLPDEVNPQQAESLGFQSDDLPQFQYFREDCAFSSPFWKDEGSDSHFTLDPPGSKKMFSSRNKEMPIDQKSLNKCSLNYICEKLEHLQSAENQDSLRSLSMHCLCAEENASSFVPHTLFRSQPKSGWSFMLRIPEKKNMMSSRQWGPIFLKVLPGGILQMYYEQGLEKPFKEIQLDPYCRLSEPKVENFSVAGKIHTVKIEHVSYTEKRKYHSKTEVVHEPDIEQMLKLGSTSYHDFLDFLTTVEEELMKLPAVSKPKKNYEEQEISLEIVDNFWGKVTKEGKFVESAVITQIYCLCFVNGNLECFLTLNDLELPKRDESYYEKDSEKKGIDILDYHFHKCVNVQEFEQSRIIKFVPLDACRFELMRFKTLYNGDNLPFSLKSVVVVQGAYVELQAFVNMASLAQRSSYAGSLRSCDNIRIHFPVPSQWIKALWTMNLQRQKSLKAKMNRRACLGSLQELESEPVIQVTVGSAKYESAYQAVVWKIDRLPDKNSSLDHPHCLSYKLELGSDQEIPSDWYPFATVQFSVPDTCASRTEVRSLGVESDVQPQKHVQQRACYNIQVEIEKKWIKIDGEDPDKIGDCITQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	DDDPAVQSSQKSKNF CCCHHHCCCCCCCCC	28.30	29507054
77	Phosphorylation	YFSPGPPSNSPLSTP ECCCCCCCCCCCCCC	53.74	27251275
79	Phosphorylation	SPGPPSNSPLSTPTK CCCCCCCCCCCCCCC	31.39	27251275
205	Ubiquitination	LDPPGSKKMFSSRNK ECCCCCHHCCCCCCC	47.04	-
209	Phosphorylation	GSKKMFSSRNKEMPI CCHHCCCCCCCCCCC	28.71	-
220	Phosphorylation	EMPIDQKSLNKCSLN CCCCCHHHHCHHHHH	31.38	26074081
225	Phosphorylation	QKSLNKCSLNYICEK HHHHCHHHHHHHHHH	22.66	26074081
228	Phosphorylation	LNKCSLNYICEKLEH HCHHHHHHHHHHHHH	16.55	26074081
244	Phosphorylation	QSAENQDSLRSLSMH HHHCCHHHHHHHHHH	18.87	30266825
247	Phosphorylation	ENQDSLRSLSMHCLC CCHHHHHHHHHHHHH	30.04	28857561
249	Phosphorylation	QDSLRSLSMHCLCAE HHHHHHHHHHHHHHH	14.02	24719451
270	Phosphorylation	VPHTLFRSQPKSGWS CCCCCCCCCCCCCCE	43.42	22210691
274	Phosphorylation	LFRSQPKSGWSFMLR CCCCCCCCCCEEEEE	52.78	22210691
277	Phosphorylation	SQPKSGWSFMLRIPE CCCCCCCEEEEECCC	12.33	22210691
346	Phosphorylation	SVAGKIHTVKIEHVS EECCEEEEEEEEEEE	27.28	-
404	Phosphorylation	LMKLPAVSKPKKNYE HHCCCCCCCCCCCHH	45.40	-
499	Phosphorylation	NVQEFEQSRIIKFVP CHHHHHHHCEEEEEE	20.46	29978859
556	Phosphorylation	MASLAQRSSYAGSLR HHHHHHHHHCCCCCC	18.67	27251275
557	Phosphorylation	ASLAQRSSYAGSLRS HHHHHHHHCCCCCCC	22.61	27251275
628	Phosphorylation	SAKYESAYQAVVWKI CCCHHHHHHHHHHHH	13.29	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STON1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STON1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STON1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of STON1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.