CLD19_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLD19_HUMAN
• UniProt AC: Q8N6F1
• Protein Name: Claudin-19
• Gene Name: CLDN19
• Organism: Homo sapiens (Human).
• Sequence Length: 224
• Subcellular Localization: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
• Protein Description: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity..
• Protein Sequence: MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAIAGGALFILAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAVLGGSFLCCTCPEPERPNSSPQPYRPGPSAAAREPVVKLPASAKGPLGV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MANSGLQLLGY ----CCCHHHHHHHH	31.20	24043423
11	Phosphorylation	SGLQLLGYFLALGGW HHHHHHHHHHHHCHH	8.73	24043423
24	Phosphorylation	GWVGIIASTALPQWK HHHHHHHHHCCHHHH	12.10	24043423
25	Phosphorylation	WVGIIASTALPQWKQ HHHHHHHHCCHHHHC	24.16	24043423
195	Phosphorylation	EPERPNSSPQPYRPG CCCCCCCCCCCCCCC	33.91	24719451
204	Phosphorylation	QPYRPGPSAAAREPV CCCCCCCCHHHCCCC	36.13	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLD19_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLD19_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLD19_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CLD19_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.