ARSG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARSG_HUMAN
• UniProt AC: Q96EG1
• Protein Name: Arylsulfatase G
• Gene Name: ARSG
• Organism: Homo sapiens (Human).
• Sequence Length: 525
• Subcellular Localization: Lysosome . Previously observed endoplasmic reticulum localization is most likely due to folding/maturation problems for overexpressed proteins.
• Protein Description: Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate..
• Protein Sequence: MGWLFLKVLLAGVSFSGFLYPLVDFCISGKTRGQKPNFVIILADDMGWGDLGANWAETKDTANLDKMASEGMRFVDFHAAASTCSPSRASLLTGRLGLRNGVTRNFAVTSVGGLPLNETTLAEVLQQAGYVTGIIGKWHLGHHGSYHPNFRGFDYYFGIPYSHDMGCTDTPGYNHPPCPACPQGDGPSRNLQRDCYTDVALPLYENLNIVEQPVNLSSLAQKYAEKATQFIQRASTSGRPFLLYVALAHMHVPLPVTQLPAAPRGRSLYGAGLWEMDSLVGQIKDKVDHTVKENTFLWFTGDNGPWAQKCELAGSVGPFTGFWQTRQGGSPAKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAQASLPQGRRFDGVDVSEVLFGRSQPGHRVLFHPNSGAAGEFGALQTVRLERYKAFYITGGARACDGSTGPELQHKFPLIFNLEDDTAEAVPLERGGAEYQAVLPEVRKVLADVLQDIANDNISSADYTQDPSVTPCCNPYQIACRCQAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
69	Phosphorylation	ANLDKMASEGMRFVD CCHHHHHHHCCCEEE	31.05	-
84	3-oxoalanine (Cys)	FHAAASTCSPSRASL HHHHHCCCCHHHHHH	5.36	-
84	Oxidation	FHAAASTCSPSRASL HHHHHCCCCHHHHHH	5.36	18283100
93	Phosphorylation	PSRASLLTGRLGLRN HHHHHHHHHCCCCCC	26.08	21815630
110	Phosphorylation	TRNFAVTSVGGLPLN CCCEEEEEECCCCCC	16.50	22210691
117	N-linked_Glycosylation	SVGGLPLNETTLAEV EECCCCCCHHCHHHH	42.50	UniProtKB CARBOHYD
120	Phosphorylation	GLPLNETTLAEVLQQ CCCCCHHCHHHHHHH	20.14	22210691
196	Phosphorylation	RNLQRDCYTDVALPL CCCCCHHHHCCHHHH	15.40	21712546
204	Phosphorylation	TDVALPLYENLNIVE HCCHHHHHCCCCCCC	10.79	21712546
215	N-linked_Glycosylation	NIVEQPVNLSSLAQK CCCCCCCCHHHHHHH	40.67	UniProtKB CARBOHYD
218	Phosphorylation	EQPVNLSSLAQKYAE CCCCCHHHHHHHHHH	30.78	21712546
226	Ubiquitination	LAQKYAEKATQFIQR HHHHHHHHHHHHHHH	48.87	-
356	N-linked_Glycosylation	WPGRVPVNVTSTALL CCCCCCCCCCHHHHH	25.86	UniProtKB CARBOHYD
371	O-linked_Glycosylation	SVLDIFPTVVALAQA HHHHHHHHHHHHHHC	19.50	OGP
379	Phosphorylation	VVALAQASLPQGRRF HHHHHHCCCCCCCCC	28.62	24719451
451	Ubiquitination	TGPELQHKFPLIFNL CCHHHHHCCCEEEEC	35.40	-
497	N-linked_Glycosylation	LQDIANDNISSADYT HHHHHCCCCCCCCCC	35.53	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARSG_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARSG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARSG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SUMF1_HUMAN	SUMF1	physical	28514442
YDJC_HUMAN	YDJC	physical	28514442
GSK3A_HUMAN	GSK3A	physical	28514442
TM214_HUMAN	TMEM214	physical	28514442
MESD_HUMAN	MESDC2	physical	28514442
CTGE5_HUMAN	CTAGE5	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
DPH1_HUMAN	DPH1	physical	28514442
IDE_HUMAN	IDE	physical	28514442
CGRF1_HUMAN	CGRRF1	physical	28514442
GATA_HUMAN	QRSL1	physical	28514442
TOR3A_HUMAN	TOR3A	physical	28514442
FBX21_HUMAN	FBXO21	physical	28514442
BACE2_HUMAN	BACE2	physical	28514442
TBB8_HUMAN	TUBB8	physical	28514442
SPCS1_HUMAN	SPCS1	physical	28514442
CALX_HUMAN	CANX	physical	28514442
E2AK3_HUMAN	EIF2AK3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.