GATA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GATA_HUMAN
• UniProt AC: Q9H0R6
• Protein Name: Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03150}
• Gene Name: QRSL1 {ECO:0000255|HAMAP-Rule:MF_03150}
• Organism: Homo sapiens (Human).
• Sequence Length: 528
• Subcellular Localization: Mitochondrion .
• Protein Description: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)..
• Protein Sequence: MLGRSLREVSAALKQGQITPTELCQKCLSLIKKTKFLNAYITVSEEVALKQAEESEKRYKNGQSLGDLDGIPIAVKDNFSTSGIETTCASNMLKGYIPPYNATVVQKLLDQGALLMGKTNLDEFAMGSGSTDGVFGPVKNPWSYSKQYREKRKQNPHSENEDSDWLITGGSSGGSAAAVSAFTCYAALGSDTGGSTRNPAAHCGLVGFKPSYGLVSRHGLIPLVNSMDVPGILTRCVDDAAIVLGALAGPDPRDSTTVHEPINKPFMLPSLADVSKLCIGIPKEYLVPELSSEVQSLWSKAADLFESEGAKVIEVSLPHTSYSIVCYHVLCTSEVASNMARFDGLQYGHRCDIDVSTEAMYAATRREGFNDVVRGRILSGNFFLLKENYENYFVKAQKVRRLIANDFVNAFNSGVDVLLTPTTLSEAVPYLEFIKEDNRTRSAQDDIFTQAVNMAGLPAVSIPVALSNQGLPIGLQFIGRAFCDQQLLTVAKWFEKQVQFPVIQLQELMDDCSAVLENEKLASVSLKQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	GRSLREVSAALKQGQ CHHHHHHHHHHHCCC	11.76	-
14	Ubiquitination	REVSAALKQGQITPT HHHHHHHHCCCCCHH	47.89	29967540
29	Phosphorylation	ELCQKCLSLIKKTKF HHHHHHHHHHHHCCC	37.20	24719451
80	Phosphorylation	IAVKDNFSTSGIETT EEEECCCCCCCCCHH	28.11	21406692
81	Phosphorylation	AVKDNFSTSGIETTC EEECCCCCCCCCHHH	27.17	21406692
82	Phosphorylation	VKDNFSTSGIETTCA EECCCCCCCCCHHHH	36.25	21406692
86	Phosphorylation	FSTSGIETTCASNML CCCCCCCHHHHHHHH	25.84	21406692
87	Phosphorylation	STSGIETTCASNMLK CCCCCCHHHHHHHHC	8.03	21406692
90	Phosphorylation	GIETTCASNMLKGYI CCCHHHHHHHHCCCC	25.56	28674151
116	Sulfoxidation	LDQGALLMGKTNLDE HHCCCHHCCCCCHHH	5.56	21406390
119	Phosphorylation	GALLMGKTNLDEFAM CCHHCCCCCHHHHCC	34.97	22210691
128	Phosphorylation	LDEFAMGSGSTDGVF HHHHCCCCCCCCCCC	19.24	22210691
130	Phosphorylation	EFAMGSGSTDGVFGP HHCCCCCCCCCCCCC	25.64	22210691
131	Phosphorylation	FAMGSGSTDGVFGPV HCCCCCCCCCCCCCC	40.05	22210691
190	Phosphorylation	TCYAALGSDTGGSTR HHHHHCCCCCCCCCC	32.61	-
192	Phosphorylation	YAALGSDTGGSTRNP HHHCCCCCCCCCCCC	45.18	-
196	Phosphorylation	GSDTGGSTRNPAAHC CCCCCCCCCCCHHCC	37.43	-
356	Phosphorylation	HRCDIDVSTEAMYAA CCCCCCCCHHHHHHH	19.44	30576142
389	Phosphorylation	FFLLKENYENYFVKA EEEEECCHHHHCHHH	13.47	25072903
392	Phosphorylation	LKENYENYFVKAQKV EECCHHHHCHHHHHH	9.60	25072903
395	Ubiquitination	NYENYFVKAQKVRRL CHHHHCHHHHHHHHH	34.89	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GATA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GATA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GATA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
K2C8_HUMAN	KRT8	physical	21900206
XRCC6_HUMAN	XRCC6	physical	21900206
GATB_HUMAN	GATB	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.