| UniProt ID | GATB_HUMAN | |
|---|---|---|
| UniProt AC | O75879 | |
| Protein Name | Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03147} | |
| Gene Name | GATB {ECO:0000255|HAMAP-Rule:MF_03147, ECO:0000312|HGNC:HGNC:8849} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 557 | |
| Subcellular Localization | Mitochondrion . | |
| Protein Description | Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).. | |
| Protein Sequence | MAAPMLRWGCRGRRWAFARVDGGSCHRRGAPTGSTSNQIRGESSVAQQPLHTAQKTRKGEHKWAAVVGLEIHAQISSNSKLFSGSQVRFSAPPNSLVSFFDASLPGTLPVLNRRCVEAAVMTGLALNCHINKKSLFDRKHYFYADLPAGYQITQQRLPIAVNGSLIYGVCAGKKQSQVIPKTVRIKQIQLEQDSGKSLHDNLRSQTLIDLNRAGVGLLEVVLEPDMSCGEEAATAVRELQLILQALGTSQANMAEGQLRVDANISVHHPGEPLGVRTEVKNLNSIRFLAKAIDYEIQRQINELENGGEILNETRSFHHKLGCTMSMRDKEGKQDYRFMPEPNLPPLVLYDATSLPAGADPQQVINIDQIRETLPELPSVTREKLVQQYGMLLEHSFTLLNEVGLLEFFQNVIKETRAEPKKVTSWVLNTFLGYLKQQNLAVSESPVTPSALAELLDLLDSRTISSSAAKQVFEELWKREGKTPGQIVSEKQLELMQDQGALEQLCHSVMEAHPQVVMDVKNRNPRAINKLIGLVRKATQSRADPVMIKEILEKKLSL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 36 | Phosphorylation | GAPTGSTSNQIRGES CCCCCCCCCCCCCCC | 28.56 | 22210691 | |
| 43 | Phosphorylation | SNQIRGESSVAQQPL CCCCCCCCCCCCCCC | 32.70 | 22210691 | |
| 90 | Phosphorylation | SGSQVRFSAPPNSLV CCCEEEEECCCCCEE | 29.33 | 20068231 | |
| 95 | Phosphorylation | RFSAPPNSLVSFFDA EEECCCCCEEEEEEC | 35.60 | 20068231 | |
| 98 | Phosphorylation | APPNSLVSFFDASLP CCCCCEEEEEECCCC | 26.03 | 20068231 | |
| 103 | Phosphorylation | LVSFFDASLPGTLPV EEEEEECCCCCCHHH | 36.62 | 20068231 | |
| 107 | Phosphorylation | FDASLPGTLPVLNRR EECCCCCCHHHHCHH | 26.42 | 20068231 | |
| 176 | Phosphorylation | VCAGKKQSQVIPKTV ECCCCCHHCCCCCEE | 34.98 | - | |
| 181 | Ubiquitination | KQSQVIPKTVRIKQI CHHCCCCCEEEEEEE | 48.83 | 23503661 | |
| 181 | Acetylation | KQSQVIPKTVRIKQI CHHCCCCCEEEEEEE | 48.83 | 19608861 | |
| 186 | Ubiquitination | IPKTVRIKQIQLEQD CCCEEEEEEEEEECC | 30.68 | 23503661 | |
| 280 | Ubiquitination | LGVRTEVKNLNSIRF CCCCEEEECHHHHHH | 49.86 | - | |
| 284 | Phosphorylation | TEVKNLNSIRFLAKA EEEECHHHHHHHHHH | 20.50 | 24719451 | |
| 290 | Ubiquitination | NSIRFLAKAIDYEIQ HHHHHHHHHHCHHHH | 48.28 | 23503661 | |
| 290 | Acetylation | NSIRFLAKAIDYEIQ HHHHHHHHHHCHHHH | 48.28 | 25953088 | |
| 319 | Ubiquitination | ETRSFHHKLGCTMSM HHHHHHHHHCCCEEC | 37.70 | 29967540 | |
| 329 | Ubiquitination | CTMSMRDKEGKQDYR CCEECCCCCCCCCCC | 58.98 | 24816145 | |
| 415 | Phosphorylation | FQNVIKETRAEPKKV HHHHHHHHCCCCCHH | 30.12 | - | |
| 460 | Phosphorylation | ELLDLLDSRTISSSA HHHHHHHCCCCCHHH | 31.15 | - | |
| 529 | Succinylation | RNPRAINKLIGLVRK CCHHHHHHHHHHHHH | 35.05 | - | |
| 529 | Malonylation | RNPRAINKLIGLVRK CCHHHHHHHHHHHHH | 35.05 | 26320211 | |
| 529 | Succinylation | RNPRAINKLIGLVRK CCHHHHHHHHHHHHH | 35.05 | - | |
| 529 | Acetylation | RNPRAINKLIGLVRK CCHHHHHHHHHHHHH | 35.05 | 25953088 | |
| 538 | Phosphorylation | IGLVRKATQSRADPV HHHHHHHHHCCCCHH | 30.07 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GATB_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GATB_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GATB_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of GATB_HUMAN !! | ||||
| Kegg Disease | |
|---|---|
| There are no disease associations of PTM sites. | |
| OMIM Disease | |
| There are no disease associations of PTM sites. | |
| Kegg Drug | |
| There are no disease associations of PTM sites. | |
| DrugBank | |
| DB00130 | L-Glutamine |
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| Acetylation | |
| Reference | PubMed |
| "Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-181, AND MASS SPECTROMETRY. | |
