CGRF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CGRF1_HUMAN
• UniProt AC: Q99675
• Protein Name: Cell growth regulator with RING finger domain protein 1
• Gene Name: CGRRF1
• Organism: Homo sapiens (Human).
• Sequence Length: 332
• Subcellular Localization: Nucleus . Endoplasmic reticulum .
• Protein Description: Able to inhibit growth in several cell lines..
• Protein Sequence: MAAVFLVTLYEYSPLFYIAVVFTCFIVTTGLVLGWFGWDVPVILRNSEETQFSTRVFKKQMRQVKNPFGLEITNPSSASITTGITLTTDCLEDSLLTCYWGCSVQKLYEALQKHVYCFRISTPQALEDALYSEYLYQEQYFIKKDSKEEIYCQLPRDTKIEDFGTVPRSRYPLVALLTLADEDDREIYDIISMVSVIHIPDRTYKLSCRILYQYLLLAQGQFHDLKQLFMSANNNFTPSNNSSSEEKNTDRSLLEKVGLSESEVEPSEENSKDCVVCQNGTVNWVLLPCRHTCLCDGCVKYFQQCPMCRQFVQESFALCSQKEQDKDKPKTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
99	Ubiquitination	EDSLLTCYWGCSVQK HHHHHHHHHCCHHHH	10.29	22817900
113	Acetylation	KLYEALQKHVYCFRI HHHHHHHHCCEEEEC	35.57	25953088
147	Ubiquitination	YFIKKDSKEEIYCQL EEECCCCCCCEEEEC	70.29	29967540
159	Ubiquitination	CQLPRDTKIEDFGTV EECCCCCCCHHCCCC	48.68	21906983
187	Ubiquitination	ADEDDREIYDIISMV CCCCCHHHHHHHHHE	3.79	22817900
196	Ubiquitination	DIISMVSVIHIPDRT HHHHHEEEEECCCCC	2.22	22817900
231	Phosphorylation	DLKQLFMSANNNFTP CHHHHHHHCCCCCCC	22.10	-
247	Ubiquitination	NNSSSEEKNTDRSLL CCCCHHHHHHCHHHH	62.18	22817900
252	Phosphorylation	EEKNTDRSLLEKVGL HHHHHCHHHHHHHCC	39.87	25159151
256	Ubiquitination	TDRSLLEKVGLSESE HCHHHHHHHCCCHHH	41.39	22817900
260	Phosphorylation	LLEKVGLSESEVEPS HHHHHCCCHHHCCCC	32.90	24245541

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CGRF1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CGRF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CGRF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PEX10_HUMAN	PEX10	physical	22493164
CBX6_HUMAN	CBX6	physical	26186194
COL12_HUMAN	COLEC12	physical	26186194
AT1A3_HUMAN	ATP1A3	physical	26186194
AT2A3_HUMAN	ATP2A3	physical	26186194
KDIS_HUMAN	KIDINS220	physical	26186194
SRBP2_HUMAN	SREBF2	physical	26186194
P121A_HUMAN	POM121	physical	26186194
CP51A_HUMAN	CYP51A1	physical	26186194
ALG13_HUMAN	ALG13	physical	26186194
T131L_HUMAN	KIAA0922	physical	26186194
PKHB2_HUMAN	PLEKHB2	physical	26186194
FOXD2_HUMAN	FOXD2	physical	26186194
UBP33_HUMAN	USP33	physical	26186194
GSLG1_HUMAN	GLG1	physical	26186194
EPHX4_HUMAN	EPHX4	physical	26186194
TM201_HUMAN	TMEM201	physical	26186194
ZN503_HUMAN	ZNF503	physical	26186194
N42L2_HUMAN	N4BP2L2	physical	26186194
COL12_HUMAN	COLEC12	physical	28514442
FOXD2_HUMAN	FOXD2	physical	28514442
KDIS_HUMAN	KIDINS220	physical	28514442
AT2A3_HUMAN	ATP2A3	physical	28514442
B4GT3_HUMAN	B4GALT3	physical	28514442
N42L2_HUMAN	N4BP2L2	physical	28514442
UBP33_HUMAN	USP33	physical	28514442
PKHB2_HUMAN	PLEKHB2	physical	28514442
SRBP2_HUMAN	SREBF2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.