FOXD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FOXD2_HUMAN
• UniProt AC: O60548
• Protein Name: Forkhead box protein D2
• Gene Name: FOXD2
• Organism: Homo sapiens (Human).
• Sequence Length: 495
• Subcellular Localization: Nucleus .
• Protein Description: Probable transcription factor involved in embryogenesis and somatogenesis..
• Protein Sequence: MTLGSCCCEIMSSESSPAALSEADADIDVVGGGSGGGELPARSGPRAPRDVLPHGHEPPAEEAEADLAEDEEESGGCSDGEPRALASRGAAAAAGSPGPGAAAARGAAGPGPGPPSGGAATRSPLVKPPYSYIALITMAILQSPKKRLTLSEICEFISGRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPESADMFDNGSFLRRRKRFKRQPLPPPHPHPHPHPELLLRGGAAAAGDPGAFLPGFAAYGAYGYGYGLALPAYGAPPPGPAPHPHPHPHAFAFAAAAAAAPCQLSVPPGRAAAPPPGPPTASVFAGAGSAPAPAPASGSGPGPGPAGLPAFLGAELGCAKAFYAASLSPPAAGTAAGLPTALLRQGLKTDAGGGAGGGGAGAGQRPSFSIDHIMGHGGGGAAPPGAGEGSPGPPFAAAAGPGGQAQVLAMLTAPALAPVAGHIRLSHPGDALLSSGSRFASKVAGLSGCHF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
74	Phosphorylation	LAEDEEESGGCSDGE HHHCHHHHCCCCCCC	43.71	30266825
78	Phosphorylation	EEESGGCSDGEPRAL HHHHCCCCCCCHHHH	52.50	30266825
96	Phosphorylation	GAAAAAGSPGPGAAA HHHHHHCCCCHHHHH	23.20	29255136
116	Phosphorylation	GPGPGPPSGGAATRS CCCCCCCCCCCCCCC	53.65	-
121	Phosphorylation	PPSGGAATRSPLVKP CCCCCCCCCCCCCCC	31.01	-
123	Phosphorylation	SGGAATRSPLVKPPY CCCCCCCCCCCCCCH	20.45	24719451
130	Phosphorylation	SPLVKPPYSYIALIT CCCCCCCHHHHHHHH	23.72	23401153
131	Phosphorylation	PLVKPPYSYIALITM CCCCCCHHHHHHHHH	18.81	23401153
132	Phosphorylation	LVKPPYSYIALITMA CCCCCHHHHHHHHHH	5.60	23401153
137	Phosphorylation	YSYIALITMAILQSP HHHHHHHHHHHHHCC	11.03	23401153
143	Phosphorylation	ITMAILQSPKKRLTL HHHHHHHCCCCCCCH	34.93	23401153
149	Phosphorylation	QSPKKRLTLSEICEF HCCCCCCCHHHHHHH	32.07	-
158	Phosphorylation	SEICEFISGRFPYYR HHHHHHHHCCCHHHH	29.27	24719451
470	Phosphorylation	VAGHIRLSHPGDALL CCCCEECCCCCHHHH	20.14	28176443
478	Phosphorylation	HPGDALLSSGSRFAS CCCHHHHCCCCHHHH	33.24	28176443
479	Phosphorylation	PGDALLSSGSRFASK CCHHHHCCCCHHHHH	40.53	28176443
481	Phosphorylation	DALLSSGSRFASKVA HHHHCCCCHHHHHHH	26.60	28176443

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FOXD2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FOXD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FOXD2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of FOXD2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.