EPHX4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EPHX4_HUMAN
• UniProt AC: Q8IUS5
• Protein Name: Epoxide hydrolase 4
• Gene Name: EPHX4
• Organism: Homo sapiens (Human).
• Sequence Length: 362
• Subcellular Localization: Membrane ; Single-pass type II membrane protein .
• Protein Sequence: MARLRDCLPRLMLTLRSLLFWSLVYCYCGLCASIHLLKLLWSLGKGPAQTFRRPAREHPPACLSDPSLGTHCYVRIKDSGLRFHYVAAGERGKPLMLLLHGFPEFWYSWRYQLREFKSEYRVVALDLRGYGETDAPIHRQNYKLDCLITDIKDILDSLGYSKCVLIGHDWGGMIAWLIAICYPEMVMKLIVINFPHPNVFTEYILRHPAQLLKSSYYYFFQIPWFPEFMFSINDFKVLKHLFTSHSTGIGRKGCQLTTEDLEAYIYVFSQPGALSGPINHYRNIFSCLPLKHHMVTTPTLLLWGENDAFMEVEMAEVTKIYVKNYFRLTILSEASHWLQQDQPDIVNKLIWTFLKEETRKKD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	CLPRLMLTLRSLLFW HHHHHHHHHHHHHHH	13.22	23532336
85	Phosphorylation	DSGLRFHYVAAGERG CCCCCEEEEEECCCC	6.78	-
130	Phosphorylation	VALDLRGYGETDAPI EEEECCCCCCCCCCC	12.83	-
142	Phosphorylation	APIHRQNYKLDCLIT CCCCCCCCCCCEEEC	12.46	-
149	Phosphorylation	YKLDCLITDIKDILD CCCCEEECCHHHHHH	20.80	-
243	Phosphorylation	KVLKHLFTSHSTGIG HHHHHHHHHCCCCCC	31.71	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EPHX4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EPHX4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EPHX4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of EPHX4_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.