BACE2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BACE2_HUMAN
• UniProt AC: Q9Y5Z0
• Protein Name: Beta-secretase 2
• Gene Name: BACE2
• Organism: Homo sapiens (Human).
• Sequence Length: 518
• Subcellular Localization: Membrane; Single-pass type I membrane protein. Golgi apparatus. Endoplasmic reticulum. Endosome. Cell surface.
• Protein Description: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672..
• Protein Sequence: MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	O-linked_Glycosylation	ALEPALASPAGAANF HHHHHHCCCCHHHHH	19.01	OGP
93	Phosphorylation	GDSGRGYYLEMLIGT CCCCCCEEEEEEECC	10.06	22817900
136	Phosphorylation	YFDTERSSTYRSKGF CCCCCCCCCCCCCCE	35.36	-
137	Phosphorylation	FDTERSSTYRSKGFD CCCCCCCCCCCCCEE	24.97	-
140	Phosphorylation	ERSSTYRSKGFDVTV CCCCCCCCCCEEEEE	27.07	-
146	Phosphorylation	RSKGFDVTVKYTQGS CCCCEEEEEEEECCC	17.08	29978859
149	Phosphorylation	GFDVTVKYTQGSWTG CEEEEEEEECCCCEE	10.44	28348404
150	Phosphorylation	FDVTVKYTQGSWTGF EEEEEEEECCCCEEE	22.27	28348404
153	Phosphorylation	TVKYTQGSWTGFVGE EEEEECCCCEEECCC	16.20	28348404
155	Phosphorylation	KYTQGSWTGFVGEDL EEECCCCEEECCCEE	23.57	28348404
164	Phosphorylation	FVGEDLVTIPKGFNT ECCCEEEECCCCCCC	38.57	29978859
170	N-linked_Glycosylation	VTIPKGFNTSFLVNI EECCCCCCCEEEEEH	43.40	UniProtKB CARBOHYD
219	Ubiquitination	ETFFDSLVTQANIPN HHHHHHHHHHCCCCC	4.28	21963094
266	Phosphorylation	YKGDIWYTPIKEEWY CCCCCEEEECCCEEE	11.98	22199227
295	Phosphorylation	LNLDCREYNADKAIV EECCCHHHCCCCEEE	9.04	20058876
299	Ubiquitination	CREYNADKAIVDSGT CHHHCCCCEEECCCC	37.29	29967540
314	Ubiquitination	TLLRLPQKVFDAVVE CEEECCHHHHHHHHH	42.82	21963094
366	N-linked_Glycosylation	SIYLRDENSSRSFRI EEEEECCCCCCCEEE	49.96	UniProtKB CARBOHYD
367 (in isoform 3)	Phosphorylation	-	25.69	26471730
368	Phosphorylation	YLRDENSSRSFRITI EEECCCCCCCEEEEE	43.45	22964224
368 (in isoform 3)	Phosphorylation	-	43.45	26471730
370 (in isoform 3)	Phosphorylation	-	22.33	26471730
391	Phosphorylation	MMGAGLNYECYRFGI CCCCCCCCEEECCCC	16.66	22964224
394	Phosphorylation	AGLNYECYRFGISPS CCCCCEEECCCCCCC	9.31	22964224
510	Phosphorylation	PEVVNDESSLVRHRW CCCCCCCCCCCCCCC	31.66	29255136
511	Phosphorylation	EVVNDESSLVRHRWK CCCCCCCCCCCCCCC	28.92	29255136

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BACE2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BACE2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BACE2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of BACE2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.