TEAN2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TEAN2_HUMAN
• UniProt AC: Q96MN5
• Protein Name: Transcription elongation factor A N-terminal and central domain-containing protein 2
• Gene Name: TCEANC2
• Organism: Homo sapiens (Human).
• Sequence Length: 208
• Subcellular Localization: Nucleus .
• Protein Sequence: MDKFVIRTPRIQNSPQKKDSGGKVYKQATIESLKRVVVVEDIKRWKTMLELPDQTKENLVEALQELKKKIPSREVLKSTRIGHTVNKMRKHSDSEVASLAREVYTEWKTFTEKHSNRPSIEVRSDPKTESLRKNAQKLLSEALELKMDHLLVENIERETFHLCSRLINGPYRRTVRALVFTLKHRAEIRAQVKSGSLPVGTFVQTHKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDKFVIRT -------CCCEEEEC	13.11	22814378
8	Phosphorylation	MDKFVIRTPRIQNSP CCCEEEECCCCCCCC	13.04	26074081
14	Phosphorylation	RTPRIQNSPQKKDSG ECCCCCCCCCCCCCC	16.60	25849741
20	Phosphorylation	NSPQKKDSGGKVYKQ CCCCCCCCCCCEEEH	59.32	-
25	Phosphorylation	KDSGGKVYKQATIES CCCCCCEEEHHHHHH	10.81	-
26	Ubiquitination	DSGGKVYKQATIESL CCCCCEEEHHHHHHH	36.12	29967540
47	Phosphorylation	EDIKRWKTMLELPDQ ECHHHHHHHHCCCHH	21.74	26546556
55	Phosphorylation	MLELPDQTKENLVEA HHCCCHHHHHHHHHH	47.94	26546556
56	Ubiquitination	LELPDQTKENLVEAL HCCCHHHHHHHHHHH	38.68	29967540
67	Ubiquitination	VEALQELKKKIPSRE HHHHHHHHHHCCCHH	51.79	29967540
78	Phosphorylation	PSREVLKSTRIGHTV CCHHHHHHHCCCHHH	20.82	26074081
79	Phosphorylation	SREVLKSTRIGHTVN CHHHHHHHCCCHHHH	25.39	26074081
84	Phosphorylation	KSTRIGHTVNKMRKH HHHCCCHHHHHHHHC	22.14	26074081
90	Ubiquitination	HTVNKMRKHSDSEVA HHHHHHHHCCHHHHH	43.92	29967540
92	Phosphorylation	VNKMRKHSDSEVASL HHHHHHCCHHHHHHH	45.96	20873877
94	Phosphorylation	KMRKHSDSEVASLAR HHHHCCHHHHHHHHH	36.66	20873877
98	Phosphorylation	HSDSEVASLAREVYT CCHHHHHHHHHHHHH	27.95	24719451
104	Phosphorylation	ASLAREVYTEWKTFT HHHHHHHHHHHHHHH	8.32	29116813
105	Phosphorylation	SLAREVYTEWKTFTE HHHHHHHHHHHHHHH	40.31	29116813
108	Ubiquitination	REVYTEWKTFTEKHS HHHHHHHHHHHHHHC	27.77	29967540
109	Phosphorylation	EVYTEWKTFTEKHSN HHHHHHHHHHHHHCC	36.54	24719451
111	Phosphorylation	YTEWKTFTEKHSNRP HHHHHHHHHHHCCCC	49.72	24719451
113	Ubiquitination	EWKTFTEKHSNRPSI HHHHHHHHHCCCCCE	49.64	29967540
127	Ubiquitination	IEVRSDPKTESLRKN EEECCCCCCHHHHHH	70.66	29967540
137	Ubiquitination	SLRKNAQKLLSEALE HHHHHHHHHHHHHHH	49.32	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TEAN2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TEAN2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TEAN2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
UB2R2_HUMAN	UBE2R2	physical	28514442
WDR70_HUMAN	WDR70	physical	28514442
UBXN7_HUMAN	UBXN7	physical	28514442
UB2R1_HUMAN	CDC34	physical	28514442
WAC2A_HUMAN	FAM21A	physical	28514442
DCA16_HUMAN	DCAF16	physical	28514442
ARI1_HUMAN	ARIH1	physical	28514442
NADAP_HUMAN	SLC4A1AP	physical	28514442
KPB2_HUMAN	PHKA2	physical	28514442
RAD18_HUMAN	RAD18	physical	28514442
DCAF1_HUMAN	VPRBP	physical	28514442
PHKG2_HUMAN	PHKG2	physical	28514442
ANR17_HUMAN	ANKRD17	physical	28514442
WASC4_HUMAN	KIAA1033	physical	28514442
HTSF1_HUMAN	HTATSF1	physical	28514442
CTR9_HUMAN	CTR9	physical	28514442
CR025_HUMAN	C18orf25	physical	28514442
PPM1G_HUMAN	PPM1G	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.