IFIT5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IFIT5_HUMAN
• UniProt AC: Q13325
• Protein Name: Interferon-induced protein with tetratricopeptide repeats 5
• Gene Name: IFIT5
• Organism: Homo sapiens (Human).
• Sequence Length: 482
• Subcellular Localization: Cell projection, ruffle membrane . Colocalized with DDX58/RIG-I at cell surface ruffles. Localizes to actin-rich protrusions from the apical cell surface.
• Protein Description: Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments. [PubMed: 25092312]
• Protein Sequence: MSEIRKDTLKAILLELECHFTWNLLKEDIDLFEVEDTIGQQLEFLTTKSRLALYNLLAYVKHLKGQNKDALECLEQAEEIIQQEHSDKEEVRSLVTWGNYAWVYYHMDQLEEAQKYTGKIGNVCKKLSSPSNYKLECPETDCEKGWALLKFGGKYYQKAKAAFEKALEVEPDNPEFNIGYAITVYRLDDSDREGSVKSFSLGPLRKAVTLNPDNSYIKVFLALKLQDVHAEAEGEKYIEEILDQISSQPYVLRYAAKFYRRKNSWNKALELLKKALEVTPTSSFLHHQMGLCYRAQMIQIKKATHNRPKGKDKLKVDELISSAIFHFKAAMERDSMFAFAYTDLANMYAEGGQYSNAEDIFRKALRLENITDDHKHQIHYHYGRFQEFHRKSENTAIHHYLEALKVKDRSPLRTKLTSALKKLSTKRLCHNALDVQSLSALGFVYKLEGEKRQAAEYYEKAQKIDPENAEFLTALCELRLSI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Ubiquitination	--MSEIRKDTLKAIL --CCHHHHHHHHHHH	61.80	29967540
61	Ubiquitination	YNLLAYVKHLKGQNK HHHHHHHHHHCCCCH	30.46	33845483
68	Ubiquitination	KHLKGQNKDALECLE HHHCCCCHHHHHHHH	36.17	29967540
105	Phosphorylation	GNYAWVYYHMDQLEE CCCHHEEEEHHHHHH	4.89	27762562
119	Ubiquitination	EAQKYTGKIGNVCKK HHHHHHCCHHHHHHH	39.37	29967540
128	Phosphorylation	GNVCKKLSSPSNYKL HHHHHHCCCCCCCCC	49.43	24719451
129	Phosphorylation	NVCKKLSSPSNYKLE HHHHHCCCCCCCCCC	42.66	28674419
133	Phosphorylation	KLSSPSNYKLECPET HCCCCCCCCCCCCCC	22.68	24719451
134	Ubiquitination	LSSPSNYKLECPETD CCCCCCCCCCCCCCC	41.90	29967540
140	Phosphorylation	YKLECPETDCEKGWA CCCCCCCCCCHHCEE	30.96	22210691
144	Ubiquitination	CPETDCEKGWALLKF CCCCCCHHCEEEHHC	67.11	32015554
150	Acetylation	EKGWALLKFGGKYYQ HHCEEEHHCCHHHHH	42.70	23954790
150	Acetylation	EKGWALLKFGGKYYQ HHCEEEHHCCHHHHH	42.70	-
154	Ubiquitination	ALLKFGGKYYQKAKA EEHHCCHHHHHHHHH	40.96	29967540
180	Phosphorylation	NPEFNIGYAITVYRL CCCCEEEEEEEEEEC	7.34	-
185	Phosphorylation	IGYAITVYRLDDSDR EEEEEEEEECCCCCC	9.23	-
190	Phosphorylation	TVYRLDDSDREGSVK EEEECCCCCCCCCEE	37.93	28348404
195	Phosphorylation	DDSDREGSVKSFSLG CCCCCCCCEEEEECC	22.94	28857561
198	Phosphorylation	DREGSVKSFSLGPLR CCCCCEEEEECCCCE	20.22	24247654
206	Ubiquitination	FSLGPLRKAVTLNPD EECCCCEECEECCCC	55.69	30230243
209	Phosphorylation	GPLRKAVTLNPDNSY CCCEECEECCCCCHH	26.19	28857561
215	Phosphorylation	VTLNPDNSYIKVFLA EECCCCCHHHEEEEE	35.30	28152594
216	Phosphorylation	TLNPDNSYIKVFLAL ECCCCCHHHEEEEEH	15.83	28152594
224	Ubiquitination	IKVFLALKLQDVHAE HEEEEEHHHHHHHHH	38.20	29967540
236	Ubiquitination	HAEAEGEKYIEEILD HHHHHCHHHHHHHHH	63.49	29967540
237	Phosphorylation	AEAEGEKYIEEILDQ HHHHCHHHHHHHHHH	14.84	23401153
246	Phosphorylation	EEILDQISSQPYVLR HHHHHHHHCCHHHHH	19.79	23401153
250	Phosphorylation	DQISSQPYVLRYAAK HHHHCCHHHHHHHHH	12.41	23401153
254	Phosphorylation	SQPYVLRYAAKFYRR CCHHHHHHHHHHHHH	13.52	23401153
257	Acetylation	YVLRYAAKFYRRKNS HHHHHHHHHHHHCCC	34.45	26051181
257	Malonylation	YVLRYAAKFYRRKNS HHHHHHHHHHHHCCC	34.45	26320211
259	Phosphorylation	LRYAAKFYRRKNSWN HHHHHHHHHHCCCHH	14.59	23401153
267	Ubiquitination	RRKNSWNKALELLKK HHCCCHHHHHHHHHH	48.36	29967540
301	Acetylation	RAQMIQIKKATHNRP HHHHHHHHHHCCCCC	21.71	25953088
335	Phosphorylation	KAAMERDSMFAFAYT HHHHHHCCHHHHHHH	23.24	-
354	Phosphorylation	MYAEGGQYSNAEDIF HHHCCCCCCCHHHHH	13.73	18452278
355	Phosphorylation	YAEGGQYSNAEDIFR HHCCCCCCCHHHHHH	22.98	18452278
392	Phosphorylation	FQEFHRKSENTAIHH HHHHHHHCCHHHHHH	35.72	30108239
395	Phosphorylation	FHRKSENTAIHHYLE HHHHCCHHHHHHHHH	23.96	29802988
405	Ubiquitination	HHYLEALKVKDRSPL HHHHHHHCCCCCCHH	55.04	29967540
410	Phosphorylation	ALKVKDRSPLRTKLT HHCCCCCCHHHHHHH	38.12	26270265
415	Acetylation	DRSPLRTKLTSALKK CCCHHHHHHHHHHHH	43.25	25953088
415	Malonylation	DRSPLRTKLTSALKK CCCHHHHHHHHHHHH	43.25	26320211
415	Ubiquitination	DRSPLRTKLTSALKK CCCHHHHHHHHHHHH	43.25	29967540
418	Phosphorylation	PLRTKLTSALKKLST HHHHHHHHHHHHHCH	41.88	28555341
460	Ubiquitination	QAAEYYEKAQKIDPE HHHHHHHHHHCCCHH	39.74	30230243
463	Ubiquitination	EYYEKAQKIDPENAE HHHHHHHCCCHHHHH	54.67	29967540
476	Glutathionylation	AEFLTALCELRLSI- HHHHHHHHHHHCCC-	4.25	22555962

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IFIT5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IFIT5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IFIT5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LONM_HUMAN	LONP1	physical	21163940
PRDX2_HUMAN	PRDX2	physical	21163940
RD23A_HUMAN	RAD23A	physical	21163940
KCTD6_HUMAN	KCTD6	physical	28514442
RNF41_HUMAN	RNF41	physical	28514442
CRKL_HUMAN	CRKL	physical	28514442
DMD_HUMAN	DMD	physical	28514442
IKKB_HUMAN	IKBKB	physical	26334375
M3K7_HUMAN	MAP3K7	physical	26334375
IKKA_HUMAN	CHUK	physical	26334375
NEMO_HUMAN	IKBKG	physical	26334375

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.