MK_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MK_HUMAN
• UniProt AC: P21741
• Protein Name: Midkine
• Gene Name: MDK
• Organism: Homo sapiens (Human).
• Sequence Length: 143
• Subcellular Localization: Secreted.
• Protein Description: Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity)..
• Protein Sequence: MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETIRVTKPCTPKTKAKAKAKKGKGKD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
101	Acetylation	CDGGTGTKVRQGTLK CCCCCCCEEECCCHH	36.44	19813189
108	Acetylation	KVRQGTLKKARYNAQ EEECCCHHHHHHHCC	44.20	19813197
119	O-linked_Glycosylation	YNAQCQETIRVTKPC HHCCCCCEEEECCCC	6.55	55830709

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MK_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MK_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MK_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NCAM1_HUMAN	NCAM1	physical	10772929
NID1_HUMAN	NID1	physical	10772929
NID2_HUMAN	NID2	physical	10772929
ACTG_HUMAN	ACTG1	physical	10772929
TBA1A_HUMAN	TUBA1A	physical	10772929
TBB2B_HUMAN	TUBB2B	physical	10772929
LRP1_HUMAN	LRP1	physical	10772929
PTPRZ_HUMAN	PTPRZ1	physical	10212223
SET1A_HUMAN	SETD1A	physical	28514442
CXXC1_HUMAN	CXXC1	physical	28514442
TNC18_HUMAN	TNRC18	physical	28514442
NAF1_HUMAN	NAF1	physical	28514442
H11_HUMAN	HIST1H1A	physical	28514442
AFF4_HUMAN	AFF4	physical	28514442
UBF1_HUMAN	UBTF	physical	28514442
AF9_HUMAN	MLLT3	physical	28514442
SRRM2_HUMAN	SRRM2	physical	28514442
CHD9_HUMAN	CHD9	physical	28514442
BD1L1_HUMAN	BOD1L1	physical	28514442
CWC22_HUMAN	CWC22	physical	28514442
RS27A_HUMAN	RPS27A	physical	28514442
CAPON_HUMAN	NOS1AP	physical	28514442
CLK2_HUMAN	CLK2	physical	28514442
RPP25_HUMAN	RPP25	physical	28514442
PININ_HUMAN	PNN	physical	28514442
BRD2_HUMAN	BRD2	physical	28514442
KBTB7_HUMAN	KBTBD7	physical	28514442
SORL_HUMAN	SORL1	physical	28514442
NO40_HUMAN	ZCCHC17	physical	28514442
PPIG_HUMAN	PPIG	physical	28514442
RL36L_HUMAN	RPL36AL	physical	28514442
PTN9_HUMAN	PTPN9	physical	28514442
NKAP_HUMAN	NKAP	physical	28514442
E41L5_HUMAN	EPB41L5	physical	28514442
SIN3A_HUMAN	SIN3A	physical	28514442
UBE2O_HUMAN	UBE2O	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.