| UniProt ID | GXLT2_HUMAN | |
|---|---|---|
| UniProt AC | A0PJZ3 | |
| Protein Name | Glucoside xylosyltransferase 2 | |
| Gene Name | GXYLT2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 443 | |
| Subcellular Localization |
Membrane Single-pass type II membrane protein . |
|
| Protein Description | Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose.. | |
| Protein Sequence | MKLRSKAAALLLLALAALLLALLSLRAGRAEPPALPARPASAPQRHPAPVPARWPGPGALPGASPGVRRRRPPRPRPRAGRRGAARLEKLARRPGEPRSFQAVLPPELWIHLAVVACGNRLEETLVMLKSAVLFSHRKIQFHIFTEDSLKPEFDKQLRQWPDSYTKKFEHRIYPITFSVGNPQEWKKLFKPCAAQRLFLPVILKDVDSLLYVDTDVLFLRPVDDIWKLLRLFNSTQLAAMAPEHEIPKIGWYSRFARHPFYGSAGVNSGVMLMNLTRIRSTQFKNSMIPTGLAWEDMLYPLYQKYKNAITWGDQDLLNIIFYFNPECLYVFPCQWNYRPDHCMYGSNCREAEHEGVSVLHGNRGVYHDDKQPTFRALYEAIRDFPFQDNLFQSMYYPLQLKFLETVHTLCGRIPQVFLKQIEKTMKRAYEKHVIIHVGPNQMH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MKLRSKAAALLL ---CCHHHHHHHHHH | 36.76 | - | |
| 6 | Ubiquitination | --MKLRSKAAALLLL --CCHHHHHHHHHHH | 35.29 | - | |
| 24 | Phosphorylation | ALLLALLSLRAGRAE HHHHHHHHHHCCCCC | 19.36 | 24719451 | |
| 89 | Acetylation | RGAARLEKLARRPGE HHHHHHHHHHCCCCC | 52.63 | 7708097 | |
| 173 | Phosphorylation | KKFEHRIYPITFSVG HHCCCCEEEEEEECC | 6.63 | 29083192 | |
| 176 | Phosphorylation | EHRIYPITFSVGNPQ CCCEEEEEEECCCHH | 12.83 | 29083192 | |
| 178 | Phosphorylation | RIYPITFSVGNPQEW CEEEEEEECCCHHHH | 22.06 | 29083192 | |
| 233 | N-linked_Glycosylation | WKLLRLFNSTQLAAM HHHHHHHCHHHHHHH | 49.06 | UniProtKB CARBOHYD | |
| 252 | Phosphorylation | EIPKIGWYSRFARHP CCCCCCCCCHHCCCC | 5.69 | 29083192 | |
| 253 | Phosphorylation | IPKIGWYSRFARHPF CCCCCCCCHHCCCCC | 17.89 | 29083192 | |
| 274 | N-linked_Glycosylation | NSGVMLMNLTRIRST CCCCEEEECCCCCCC | 34.01 | UniProtKB CARBOHYD | |
| 276 | Phosphorylation | GVMLMNLTRIRSTQF CCEEEECCCCCCCCC | 21.03 | - | |
| 281 | Phosphorylation | NLTRIRSTQFKNSMI ECCCCCCCCCCCCCC | 28.33 | - | |
| 393 | O-linked_Glycosylation | FQDNLFQSMYYPLQL CCCCCHHHCCHHHHH | 11.04 | OGP |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GXLT2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GXLT2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GXLT2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of GXLT2_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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