AGRG5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AGRG5_HUMAN
• UniProt AC: Q8IZF4
• Protein Name: Adhesion G-protein coupled receptor G5
• Gene Name: ADGRG5
• Organism: Homo sapiens (Human).
• Sequence Length: 528
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide-binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking)..
• Protein Sequence: MDHCGALFLCLCLLTLQNATTETWEELLSYMENMQVSRGRSSVFSSRQLHQLEQMLLNTSFPGYNLTLQTPTIQSLAFKLSCDFSGLSLTSATLKRVPQAGGQHARGQHAMQFPAELTRDACKTRPRELRLICIYFSNTHFFKDENNSSLLNNYVLGAQLSHGHVNNLRDPVNISFWHNQSLEGYTLTCVFWKEGARKQPWGGWSPEGCRTEQPSHSQVLCRCNHLTYFAVLMQLSPALVPAELLAPLTYISLVGCSISIVASLITVLLHFHFRKQSDSLTRIHMNLHASVLLLNIAFLLSPAFAMSPVPGSACTALAAALHYALLSCLTWMAIEGFNLYLLLGRVYNIYIRRYVFKLGVLGWGAPALLVLLSLSVKSSVYGPCTIPVFDSWENGTGFQNMSICWVRSPVVHSVLVMGYGGLTSLFNLVVLAWALWTLRRLRERADAPSVRACHDTVTVLGLTVLLGTTWALAFFSFGVFLLPQLFLFTILNSLYGFFLFLWFCSQRCRSEAEAKAQIEAFSSSQTTQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	FLCLCLLTLQNATTE HHHHHHHHHHCCCHH		24043423
18	N-linked_Glycosylation	LCLLTLQNATTETWE HHHHHHHCCCHHHHH		UniProtKB CARBOHYD
20	Phosphorylation	LLTLQNATTETWEEL HHHHHCCCHHHHHHH		24043423
21	Phosphorylation	LTLQNATTETWEELL HHHHCCCHHHHHHHH		24043423
23	Phosphorylation	LQNATTETWEELLSY HHCCCHHHHHHHHHH		24043423
29	Phosphorylation	ETWEELLSYMENMQV HHHHHHHHHHHHHCC		24043423
30	Phosphorylation	TWEELLSYMENMQVS HHHHHHHHHHHHCCC		24043423
37	Phosphorylation	YMENMQVSRGRSSVF HHHHHCCCCCCCHHC		24043423
58	N-linked_Glycosylation	QLEQMLLNTSFPGYN HHHHHHHCCCCCCCC		UniProtKB CARBOHYD
59	Phosphorylation	LEQMLLNTSFPGYNL HHHHHHCCCCCCCCE		24043423
60	Phosphorylation	EQMLLNTSFPGYNLT HHHHHCCCCCCCCEE		24043423
64	Phosphorylation	LNTSFPGYNLTLQTP HCCCCCCCCEEEECC		24043423
65	N-linked_Glycosylation	NTSFPGYNLTLQTPT CCCCCCCCEEEECCC		UniProtKB CARBOHYD
67	Phosphorylation	SFPGYNLTLQTPTIQ CCCCCCEEEECCCHH		24043423
70	Phosphorylation	GYNLTLQTPTIQSLA CCCEEEECCCHHHHH		24043423
72	Phosphorylation	NLTLQTPTIQSLAFK CEEEECCCHHHHHHH		24043423
75	Phosphorylation	LQTPTIQSLAFKLSC EECCCHHHHHHHHCC		24043423
146	N-linked_Glycosylation	THFFKDENNSSLLNN CCCEECCCCHHHCHH		UniProtKB CARBOHYD
147	N-linked_Glycosylation	HFFKDENNSSLLNNY CCEECCCCHHHCHHH		UniProtKB CARBOHYD
173	N-linked_Glycosylation	NNLRDPVNISFWHNQ CCCCCCEEEEEEECC		UniProtKB CARBOHYD
179	N-linked_Glycosylation	VNISFWHNQSLEGYT EEEEEEECCCCCCEE		UniProtKB CARBOHYD
373	Phosphorylation	PALLVLLSLSVKSSV HHHHHHHHHCCCCCC		24719451
394	N-linked_Glycosylation	PVFDSWENGTGFQNM EEECCCCCCCCCCCE		UniProtKB CARBOHYD
400	N-linked_Glycosylation	ENGTGFQNMSICWVR CCCCCCCCEEEEEEC		UniProtKB CARBOHYD
523	Phosphorylation	AQIEAFSSSQTTQ-- HHHHHHHHCCCCC--		22115753
524	Phosphorylation	QIEAFSSSQTTQ--- HHHHHHHCCCCC---		22115753
526	Phosphorylation	EAFSSSQTTQ----- HHHHHCCCCC-----		22115753
527	Phosphorylation	AFSSSQTTQ------ HHHHCCCCC------		22115753

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AGRG5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AGRG5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AGRG5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PLPR3_HUMAN	LPPR3	physical	28514442
TSN10_HUMAN	TSPAN10	physical	28514442
TMM68_HUMAN	TMEM68	physical	28514442
SC11C_HUMAN	SEC11C	physical	28514442
CXG1_HUMAN	GJC1	physical	28514442
FZD3_HUMAN	FZD3	physical	28514442
SC6A6_HUMAN	SLC6A6	physical	28514442
EPHB3_HUMAN	EPHB3	physical	28514442
FZD2_HUMAN	FZD2	physical	28514442
REEP6_HUMAN	REEP6	physical	28514442
TMX4_HUMAN	TMX4	physical	28514442
GPM6B_HUMAN	GPM6B	physical	28514442
CXA1_HUMAN	GJA1	physical	28514442
BMR1A_HUMAN	BMPR1A	physical	28514442
GRM1B_HUMAN	GRAMD1B	physical	28514442
SIDT2_HUMAN	SIDT2	physical	28514442
OSBL8_HUMAN	OSBPL8	physical	28514442
MSPD2_HUMAN	MOSPD2	physical	28514442
ALG9_HUMAN	ALG9	physical	28514442
ZNT1_HUMAN	SLC30A1	physical	28514442
ATLA3_HUMAN	ATL3	physical	28514442
ANO6_HUMAN	ANO6	physical	28514442
GRM1A_HUMAN	GRAMD1A	physical	28514442
TSN3_HUMAN	TSPAN3	physical	28514442
AVR2B_HUMAN	ACVR2B	physical	28514442
EDEM2_HUMAN	EDEM2	physical	28514442
AT133_HUMAN	ATP13A3	physical	28514442
ASPH2_HUMAN	ASPHD2	physical	28514442
S39A1_HUMAN	SLC39A1	physical	28514442
FSTL1_HUMAN	FSTL1	physical	28514442
GPM6A_HUMAN	GPM6A	physical	28514442
SGMR1_HUMAN	SIGMAR1	physical	28514442
DJC18_HUMAN	DNAJC18	physical	28514442
FLVC1_HUMAN	FLVCR1	physical	28514442
FAM3C_HUMAN	FAM3C	physical	28514442
LRP10_HUMAN	LRP10	physical	28514442
VPP1_HUMAN	ATP6V0A1	physical	28514442
KLRG2_HUMAN	KLRG2	physical	28514442
PPAL_HUMAN	ACP2	physical	28514442
S19A2_HUMAN	SLC19A2	physical	28514442
TMED7_HUMAN	TMED7	physical	28514442
ACV1B_HUMAN	ACVR1B	physical	28514442
HMDH_HUMAN	HMGCR	physical	28514442
S29A1_HUMAN	SLC29A1	physical	28514442
LCLT1_HUMAN	LCLAT1	physical	28514442
ABCA3_HUMAN	ABCA3	physical	28514442
TMUB1_HUMAN	TMUB1	physical	28514442
S47A1_HUMAN	SLC47A1	physical	28514442
S12A9_HUMAN	SLC12A9	physical	28514442
SPPL3_HUMAN	SPPL3	physical	28514442
CREL1_HUMAN	CRELD1	physical	28514442
PIGO_HUMAN	PIGO	physical	28514442
SERC1_HUMAN	SERINC1	physical	28514442
MFSD8_HUMAN	MFSD8	physical	28514442
ERGI3_HUMAN	ERGIC3	physical	28514442
FZD6_HUMAN	FZD6	physical	28514442
INGR1_HUMAN	IFNGR1	physical	28514442
SOAT1_HUMAN	SOAT1	physical	28514442
PTN1_HUMAN	PTPN1	physical	28514442
F213A_HUMAN	FAM213A	physical	28514442
NGBR_HUMAN	NUS1	physical	28514442
SNG2_HUMAN	SYNGR2	physical	28514442
TRI59_HUMAN	TRIM59	physical	28514442
CTGE5_HUMAN	CTAGE5	physical	28514442
MTR1L_HUMAN	GPR50	physical	28514442
SG196_HUMAN	POMK	physical	28514442
SPP2B_HUMAN	SPPL2B	physical	28514442
ABCB8_HUMAN	ABCB8	physical	28514442
PIGM_HUMAN	PIGM	physical	28514442
ACHA5_HUMAN	CHRNA5	physical	28514442
BRAT1_HUMAN	BRAT1	physical	28514442
CALX_HUMAN	CANX	physical	28514442
DCAKD_HUMAN	DCAKD	physical	28514442
RFT1_HUMAN	RFT1	physical	28514442
FITM2_HUMAN	FITM2	physical	28514442
SGPP1_HUMAN	SGPP1	physical	28514442
LSR_HUMAN	LSR	physical	28514442
ABHEA_HUMAN	ABHD14A	physical	28514442
TNFL9_HUMAN	TNFSF9	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.