PLPR3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLPR3_HUMAN
• UniProt AC: Q6T4P5
• Protein Name: Phospholipid phosphatase-related protein type 3 {ECO:0000305}
• Gene Name: PLPPR3 {ECO:0000312|HGNC:HGNC:23497}
• Organism: Homo sapiens (Human).
• Sequence Length: 718
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MISTKEKNKIPKDSMTLLPCFYFVELPIVASSIVSLYFLELTDLFKPAKVGFQCYDRTLSMPYVETNEELIPLLMLLSLAFAAPAASIMVAEGMLYCLQSRLWGRAGGPAGAEGSINAGGCNFNSFLRRTVRFVGVHVFGLCATALVTDVIQLATGYHTPFFLTVCKPNYTLLGTSCEVNPYITQDICSGHDIHAILSARKTFPSQHATLSAFAAVYVSMYFNSVISDTTKLLKPILVFAFAIAAGVCGLTQITQYRSHPVDVYAGFLIGAGIAAYLACHAVGNFQAPPAEKPAAPAPAKDALRALTQRGHDSVYQQNKSVSTDELGPPGRLEGAPRPVAREKTSLGSLKRASVDVDLLAPRSPMAKENMVTFSHTLPRASAPSLDDPARRHMTIHVPLDASRSKQLISEWKQKSLEGRGLGLPDDASPGHLRAPAEPMAEEEEEEEDEEEEEEEEEEEDEGPAPPSLYPTVQARPGLGPRVILPPRAGPPPLVHIPEEGAQTGAGLSPKSGAGVRAKWLMMAEKSGAAVANPPRLLQVIAMSKAPGAPGPKAAETASSSSASSDSSQYRSPSDRDSASIVTIDAHAPHHPVVHLSAGGAPWEWKAAGGGAKAEADGGYELGDLARGFRGGAKPPGVSPGSSVSDVDQEEPRFGAVATVNLATGEGLPPLGAADGALGPGSRESTLRRHAGGLGLAEREAEAEAEGYFRKMQARRFPD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
169	N-linked_Glycosylation	FLTVCKPNYTLLGTS EEEEECCCEEEECCE		UniProtKB CARBOHYD
198	Phosphorylation	HDIHAILSARKTFPS CCHHHHHHCCCCCCC		24719451
300	Ubiquitination	PAAPAPAKDALRALT CCCCCCHHHHHHHHH		32142685
318	N-linked_Glycosylation	HDSVYQQNKSVSTDE CHHHHHCCCCCCCCC		UniProtKB CARBOHYD
319	Ubiquitination	DSVYQQNKSVSTDEL HHHHHCCCCCCCCCC		32142685
320	Phosphorylation	SVYQQNKSVSTDELG HHHHCCCCCCCCCCC		27732954
322	Phosphorylation	YQQNKSVSTDELGPP HHCCCCCCCCCCCCC		27732954
323	Phosphorylation	QQNKSVSTDELGPPG HCCCCCCCCCCCCCC		27732954
328	Ubiquitination	VSTDELGPPGRLEGA CCCCCCCCCCCCCCC		32142685
345	Phosphorylation	PVAREKTSLGSLKRA CCCCCCCCCCCCCCC		32142685
347	Ubiquitination	AREKTSLGSLKRASV CCCCCCCCCCCCCCC		32142685
348	Phosphorylation	REKTSLGSLKRASVD CCCCCCCCCCCCCCC		32142685
350	Ubiquitination	KTSLGSLKRASVDVD CCCCCCCCCCCCCCE		32142685
350	Phosphorylation	KTSLGSLKRASVDVD CCCCCCCCCCCCCCE		32142685
353	Phosphorylation	LGSLKRASVDVDLLA CCCCCCCCCCCEEEC		28450419
363	Phosphorylation	VDLLAPRSPMAKENM CEEECCCCCCHHHCC		32142685
367	Ubiquitination	APRSPMAKENMVTFS CCCCCCHHHCCEEEE		22817900
368 (in isoform 1)	Ubiquitination	-		21890473
368 (in isoform 2)	Ubiquitination	-		21890473
372	Phosphorylation	MAKENMVTFSHTLPR CHHHCCEEEECCCCC		23663014
373	Phosphorylation	AKENMVTFSHTLPRA HHHCCEEEECCCCCC		32142685
374	Phosphorylation	KENMVTFSHTLPRAS HHCCEEEECCCCCCC		23663014
376	Phosphorylation	NMVTFSHTLPRASAP CCEEEECCCCCCCCC		23663014
378	Ubiquitination	VTFSHTLPRASAPSL EEEECCCCCCCCCCC		32142685
381	Phosphorylation	SHTLPRASAPSLDDP ECCCCCCCCCCCCCH		24719451
384	Phosphorylation	LPRASAPSLDDPARR CCCCCCCCCCCHHHH		23663014
391	Phosphorylation	SLDDPARRHMTIHVP CCCCHHHHCCEEEEE		32142685
395	Ubiquitination	PARRHMTIHVPLDAS HHHHCCEEEEECCCH		21890473
402	Phosphorylation	IHVPLDASRSKQLIS EEEECCCHHHHHHHH		30257219
404	Phosphorylation	VPLDASRSKQLISEW EECCCHHHHHHHHHH		32142685
428	Phosphorylation	LGLPDDASPGHLRAP CCCCCCCCCCCCCCC		25003641
456	Phosphorylation	EEEEEEEEEEEDEGP HHHHHHHHHHCCCCC		32142685
503	Phosphorylation	IPEEGAQTGAGLSPK CCCCCCCCCCCCCCC		27732954
508	Phosphorylation	AQTGAGLSPKSGAGV CCCCCCCCCCCCCCH		28450419
526	Phosphorylation	WLMMAEKSGAAVANP EEEHHHHHCCCCCCC		-
536	Phosphorylation	AVANPPRLLQVIAMS CCCCCHHHHHHHHHH		32142685
543	Phosphorylation	LLQVIAMSKAPGAPG HHHHHHHHCCCCCCC		22167270
559	Phosphorylation	KAAETASSSSASSDS CHHHHCCCCCCCCCC		-
619	Phosphorylation	KAEADGGYELGDLAR EEECCCCCCHHHHHC		21552520
638	Phosphorylation	GAKPPGVSPGSSVSD CCCCCCCCCCCCCCC		27732954
641	Phosphorylation	PPGVSPGSSVSDVDQ CCCCCCCCCCCCCCC		27732954
642	Phosphorylation	PGVSPGSSVSDVDQE CCCCCCCCCCCCCCC		27732954
644	Phosphorylation	VSPGSSVSDVDQEEP CCCCCCCCCCCCCCC		27732954
666	Phosphorylation	VNLATGEGLPPLGAA EECCCCCCCCCCCCC		32142685
681	Phosphorylation	DGALGPGSRESTLRR CCCCCCCCHHHHHHH		32142685
684	Phosphorylation	LGPGSRESTLRRHAG CCCCCHHHHHHHHCC		24719451
685	Phosphorylation	GPGSRESTLRRHAGG CCCCHHHHHHHHCCC		24719451
709	Phosphorylation	AEAEGYFRKMQARRF HHHHHHHHHHHHHCC		32142685

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLPR3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLPR3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLPR3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BAG6_HUMAN	BAG6	physical	16169070

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.